00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2009 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 #include "AbstractSimpleCellCycleModel.hpp" 00029 00030 00031 void AbstractSimpleCellCycleModel::Initialise() 00032 { 00033 SetG1Duration(); 00034 } 00035 00036 00037 void AbstractSimpleCellCycleModel::InitialiseDaughterCell() 00038 { 00039 AbstractCellCycleModel::InitialiseDaughterCell(); 00040 SetG1Duration(); 00041 } 00042 00043 00044 void AbstractSimpleCellCycleModel::SetG1Duration() 00045 { 00046 assert(mpCell!=NULL); 00047 00048 switch (mpCell->GetCellType()) 00049 { 00050 case STEM: 00051 mG1Duration = TissueConfig::Instance()->GetStemCellG1Duration(); 00052 break; 00053 case TRANSIT: 00054 mG1Duration = TissueConfig::Instance()->GetTransitCellG1Duration(); 00055 break; 00056 case DIFFERENTIATED: 00057 mG1Duration = DBL_MAX; 00058 break; 00059 case APOPTOTIC: 00060 mG1Duration = DBL_MAX; 00061 break; 00062 default: 00063 NEVER_REACHED; 00064 } 00065 } 00066 00067 00068 void AbstractSimpleCellCycleModel::ResetForDivision() 00069 { 00070 AbstractCellCycleModel::ResetForDivision(); 00071 mBirthTime = SimulationTime::Instance()->GetTime(); 00072 SetG1Duration(); 00073 } 00074 00075 00076 void AbstractSimpleCellCycleModel::UpdateCellCyclePhase() 00077 { 00078 double time_since_birth = GetAge(); 00079 assert(time_since_birth>=0); 00080 00081 if (mpCell->GetCellType()==DIFFERENTIATED) 00082 { 00083 mCurrentCellCyclePhase = G_ZERO_PHASE; 00084 } 00085 else if ( time_since_birth < GetMDuration() ) 00086 { 00087 mCurrentCellCyclePhase = M_PHASE; 00088 } 00089 else if ( time_since_birth < GetMDuration() + mG1Duration) 00090 { 00091 mCurrentCellCyclePhase = G_ONE_PHASE; 00092 } 00093 else if ( time_since_birth < GetMDuration() + mG1Duration + GetSDuration()) 00094 { 00095 mCurrentCellCyclePhase = S_PHASE; 00096 } 00097 else if ( time_since_birth < GetMDuration() + mG1Duration + GetSDuration() + GetG2Duration()) 00098 { 00099 mCurrentCellCyclePhase = G_TWO_PHASE; 00100 } 00101 }