00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2009 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 #include "AbstractCellCycleModel.hpp" 00029 00030 00031 AbstractCellCycleModel::AbstractCellCycleModel() 00032 : mpCell(NULL), 00033 mBirthTime(SimulationTime::Instance()->GetTime()), 00034 mCurrentCellCyclePhase(M_PHASE), 00035 mG1Duration(DOUBLE_UNSET), 00036 mReadyToDivide(false) 00037 { 00038 } 00039 00040 00041 AbstractCellCycleModel::~AbstractCellCycleModel() 00042 { 00043 // Don't delete the cell - the cell deletes the cell cycle model 00044 // when it is destroyed (not the following way round): 00045 // delete mpCell; 00046 } 00047 00048 00049 void AbstractCellCycleModel::SetCell(TissueCell* pCell) 00050 { 00051 mpCell = pCell; 00052 } 00053 00054 00055 TissueCell* AbstractCellCycleModel::GetCell() 00056 { 00057 assert(mpCell!=NULL); 00058 return mpCell; 00059 } 00060 00061 00062 void AbstractCellCycleModel::SetBirthTime(double birthTime) 00063 { 00064 mBirthTime = birthTime; 00065 } 00066 00067 00068 double AbstractCellCycleModel::GetBirthTime() const 00069 { 00070 return mBirthTime; 00071 } 00072 00073 00074 double AbstractCellCycleModel::GetAge() 00075 { 00076 return SimulationTime::Instance()->GetTime() - mBirthTime; 00077 } 00078 00079 00080 CellCyclePhase AbstractCellCycleModel::GetCurrentCellCyclePhase() 00081 { 00082 return mCurrentCellCyclePhase; 00083 } 00084 00085 00086 void AbstractCellCycleModel::ResetForDivision() 00087 { 00088 assert(mReadyToDivide); 00089 mCurrentCellCyclePhase = M_PHASE; 00090 mReadyToDivide = false; 00091 } 00092 00093 00094 AbstractCellCycleModel* AbstractCellCycleModel::CreateCellCycleModel() 00095 { 00096 return CreateDaughterCellCycleModel(); 00097 } 00098 00099 00100 double AbstractCellCycleModel::GetSDuration() 00101 { 00102 return CancerParameters::Instance()->GetSDuration(); 00103 } 00104 00105 00106 double AbstractCellCycleModel::GetG1Duration() 00107 { 00108 return mG1Duration; 00109 } 00110 00111 00112 double AbstractCellCycleModel::GetG2Duration() 00113 { 00114 return CancerParameters::Instance()->GetG2Duration(); 00115 } 00116 00117 00118 double AbstractCellCycleModel::GetMDuration() 00119 { 00120 return CancerParameters::Instance()->GetMDuration(); 00121 } 00122 00123 00124 bool AbstractCellCycleModel::ReadyToDivide() 00125 { 00126 assert(mpCell != NULL); 00127 00128 if (!mReadyToDivide) 00129 { 00130 UpdateCellCyclePhase(); 00131 if ( (mCurrentCellCyclePhase != G_ZERO_PHASE) && 00132 (GetAge() >= GetMDuration() + GetG1Duration() + GetSDuration() + GetG2Duration()) ) 00133 { 00134 mReadyToDivide = true; 00135 } 00136 } 00137 return mReadyToDivide; 00138 }