00001 #ifndef _FaberRudy2000Version3_
00002 #define _FaberRudy2000Version3_
00003
00004
00005
00006
00007
00008
00009 #include <cmath>
00010 #include <cassert>
00011 #include "AbstractCardiacCell.hpp"
00012 #include "Exception.hpp"
00013 #include "AbstractStimulusFunction.hpp"
00014 #include "OdeSystemInformation.hpp"
00015
00016 class FaberRudy2000Version3 : public AbstractCardiacCell
00017 {
00018 private:
00019
00020 double mScaleFactorGks;
00021 double mScaleFactorIto;
00022 double mScaleFactorGkr;
00023 public:
00024 FaberRudy2000Version3(AbstractIvpOdeSolver *pSolver,
00025 AbstractStimulusFunction *pIntracellularStimulus)
00026 : AbstractCardiacCell(pSolver, 25, 0, pIntracellularStimulus)
00027 {
00028 mpSystemInfo = OdeSystemInformation<FaberRudy2000Version3>::Instance();
00029
00030 mScaleFactorGks=1.0;
00031 mScaleFactorIto=0.0;
00032 mScaleFactorGkr=1.0;
00033
00034 Init();
00035 }
00036
00037 ~FaberRudy2000Version3(void)
00038 {
00039 }
00040
00041 void SetScaleFactorGks(double sfgks)
00042 {
00043 assert(sfgks>=0.0);
00044 mScaleFactorGks=sfgks;
00045 }
00046
00047 void SetScaleFactorIto(double sfito)
00048 {
00049 assert(sfito>=0.0);
00050 mScaleFactorIto=sfito;
00051 }
00052
00053 void SetScaleFactorGkr(double sfgkr)
00054 {
00055 assert(sfgkr>=0.0);
00056 mScaleFactorGkr=sfgkr;
00057 }
00058
00059 double GetIIonic()
00060 {
00061 std::vector<double>& rY = rGetStateVariables();
00062 double var_membrane__V = rY[0];
00063
00064 double var_fast_sodium_current_m_gate__m = rY[1];
00065
00066 double var_fast_sodium_current_h_gate__h = rY[2];
00067
00068 double var_fast_sodium_current_j_gate__j = rY[3];
00069
00070 double var_L_type_Ca_channel_d_gate__d = rY[4];
00071
00072 double var_L_type_Ca_channel_f_gate__f = rY[5];
00073
00074 double var_T_type_Ca_channel_b_gate__b = rY[6];
00075
00076 double var_T_type_Ca_channel_g_gate__g = rY[7];
00077
00078 double var_rapid_delayed_rectifier_potassium_current_xr_gate__xr = rY[8];
00079
00080 double var_slow_delayed_rectifier_potassium_current_xs1_gate__xs1 = rY[9];
00081
00082 double var_slow_delayed_rectifier_potassium_current_xs2_gate__xs2 = rY[10];
00083
00084 double var_transient_outward_current_zdv_gate__zdv = rY[11];
00085
00086 double var_transient_outward_current_ydv_gate__ydv = rY[12];
00087
00088 double var_calcium_dynamics__Cai = rY[13];
00089
00090 double var_ionic_concentrations__Nai = rY[23];
00091
00092 double var_ionic_concentrations__Ki = rY[24];
00093
00094
00095 const double var_membrane__R = 8314.0;
00096 const double var_membrane__T = 310.0;
00097 const double var_membrane__F = 96485.0;
00098 double var_fast_sodium_current__j = var_fast_sodium_current_j_gate__j;
00099 double var_fast_sodium_current__h = var_fast_sodium_current_h_gate__h;
00100 const double var_fast_sodium_current__g_Na = 16.0;
00101 double var_fast_sodium_current__m = var_fast_sodium_current_m_gate__m;
00102 double var_fast_sodium_current__V = var_membrane__V;
00103 double var_fast_sodium_current__R = var_membrane__R;
00104 double var_fast_sodium_current__F = var_membrane__F;
00105 const double var_ionic_concentrations__Nao = 132.0;
00106 double var_fast_sodium_current__Nao = var_ionic_concentrations__Nao;
00107 double var_fast_sodium_current__Nai = var_ionic_concentrations__Nai;
00108 double var_fast_sodium_current__T = var_membrane__T;
00109 double var_fast_sodium_current__E_Na = ((var_fast_sodium_current__R * var_fast_sodium_current__T) / var_fast_sodium_current__F) * log(var_fast_sodium_current__Nao / var_fast_sodium_current__Nai);
00110 double var_fast_sodium_current__i_Na = var_fast_sodium_current__g_Na * pow(var_fast_sodium_current__m, 3.0) * var_fast_sodium_current__h * var_fast_sodium_current__j * (var_fast_sodium_current__V - var_fast_sodium_current__E_Na);
00111 double var_membrane__i_Na = var_fast_sodium_current__i_Na;
00112 double var_L_type_Ca_channel__d = var_L_type_Ca_channel_d_gate__d;
00113 double var_L_type_Ca_channel__f = var_L_type_Ca_channel_f_gate__f;
00114 const double var_L_type_Ca_channel_f_Ca_gate__Km_Ca = 0.0006;
00115 double var_L_type_Ca_channel__Cai = var_calcium_dynamics__Cai;
00116 double var_L_type_Ca_channel_f_Ca_gate__Cai = var_L_type_Ca_channel__Cai;
00117 double var_L_type_Ca_channel_f_Ca_gate__f_Ca = 1.0 / (1.0 + (var_L_type_Ca_channel_f_Ca_gate__Cai / var_L_type_Ca_channel_f_Ca_gate__Km_Ca));
00118 double var_L_type_Ca_channel__f_Ca = var_L_type_Ca_channel_f_Ca_gate__f_Ca;
00119 const double var_L_type_Ca_channel__gamma_Cai = 1.0;
00120 const double var_L_type_Ca_channel__gamma_Cao = 0.341;
00121 const double var_calcium_dynamics__Cao = 1.8;
00122 double var_L_type_Ca_channel__Cao = var_calcium_dynamics__Cao;
00123 double var_L_type_Ca_channel__F = var_membrane__F;
00124 const double var_L_type_Ca_channel__P_Ca = 0.00054;
00125 double var_L_type_Ca_channel__T = var_membrane__T;
00126 double var_L_type_Ca_channel__V = var_membrane__V;
00127 double var_L_type_Ca_channel__R = var_membrane__R;
00128 double var_L_type_Ca_channel__I_CaCa = (((var_L_type_Ca_channel__P_Ca * pow(2.0, 2.0) * var_L_type_Ca_channel__V * pow(var_L_type_Ca_channel__F, 2.0)) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T)) * ((var_L_type_Ca_channel__gamma_Cai * var_L_type_Ca_channel__Cai * exp((2.0 * var_L_type_Ca_channel__V * var_L_type_Ca_channel__F) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T))) - (var_L_type_Ca_channel__gamma_Cao * var_L_type_Ca_channel__Cao))) / (exp((2.0 * var_L_type_Ca_channel__V * var_L_type_Ca_channel__F) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T)) - 1.0);
00129 double var_L_type_Ca_channel__i_CaCa = var_L_type_Ca_channel__d * var_L_type_Ca_channel__f * var_L_type_Ca_channel__f_Ca * var_L_type_Ca_channel__I_CaCa;
00130 const double var_L_type_Ca_channel__P_Na = 6.75e-07;
00131 const double var_L_type_Ca_channel__gamma_Nao = 0.75;
00132 double var_L_type_Ca_channel__Nao = var_ionic_concentrations__Nao;
00133 double var_L_type_Ca_channel__Nai = var_ionic_concentrations__Nai;
00134 const double var_L_type_Ca_channel__gamma_Nai = 0.75;
00135 double var_L_type_Ca_channel__I_CaNa = (((var_L_type_Ca_channel__P_Na * pow(1.0, 2.0) * var_L_type_Ca_channel__V * pow(var_L_type_Ca_channel__F, 2.0)) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T)) * ((var_L_type_Ca_channel__gamma_Nai * var_L_type_Ca_channel__Nai * exp((1.0 * var_L_type_Ca_channel__V * var_L_type_Ca_channel__F) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T))) - (var_L_type_Ca_channel__gamma_Nao * var_L_type_Ca_channel__Nao))) / (exp((1.0 * var_L_type_Ca_channel__V * var_L_type_Ca_channel__F) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T)) - 1.0);
00136 double var_L_type_Ca_channel__i_CaNa = var_L_type_Ca_channel__d * var_L_type_Ca_channel__f * var_L_type_Ca_channel__f_Ca * var_L_type_Ca_channel__I_CaNa;
00137 const double var_ionic_concentrations__Ko = 4.5;
00138 double var_L_type_Ca_channel__Ko = var_ionic_concentrations__Ko;
00139 double var_L_type_Ca_channel__Ki = var_ionic_concentrations__Ki;
00140 const double var_L_type_Ca_channel__P_K = 1.93e-07;
00141 const double var_L_type_Ca_channel__gamma_Ki = 0.75;
00142 const double var_L_type_Ca_channel__gamma_Ko = 0.75;
00143 double var_L_type_Ca_channel__I_CaK = (((var_L_type_Ca_channel__P_K * pow(1.0, 2.0) * var_L_type_Ca_channel__V * pow(var_L_type_Ca_channel__F, 2.0)) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T)) * ((var_L_type_Ca_channel__gamma_Ki * var_L_type_Ca_channel__Ki * exp((1.0 * var_L_type_Ca_channel__V * var_L_type_Ca_channel__F) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T))) - (var_L_type_Ca_channel__gamma_Ko * var_L_type_Ca_channel__Ko))) / (exp((1.0 * var_L_type_Ca_channel__V * var_L_type_Ca_channel__F) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T)) - 1.0);
00144 double var_L_type_Ca_channel__i_CaK = var_L_type_Ca_channel__d * var_L_type_Ca_channel__f * var_L_type_Ca_channel__f_Ca * var_L_type_Ca_channel__I_CaK;
00145 double var_L_type_Ca_channel__i_Ca_L = var_L_type_Ca_channel__i_CaCa + var_L_type_Ca_channel__i_CaK + var_L_type_Ca_channel__i_CaNa;
00146 double var_membrane__i_Ca_L = var_L_type_Ca_channel__i_Ca_L;
00147 double var_T_type_Ca_channel__V = var_membrane__V;
00148 double var_T_type_Ca_channel__g = var_T_type_Ca_channel_g_gate__g;
00149 const double var_T_type_Ca_channel__g_CaT = 0.05;
00150 double var_T_type_Ca_channel__b = var_T_type_Ca_channel_b_gate__b;
00151 double var_calcium_background_current__R = var_membrane__R;
00152 double var_calcium_background_current__Cai = var_calcium_dynamics__Cai;
00153 double var_calcium_background_current__F = var_membrane__F;
00154 double var_calcium_background_current__T = var_membrane__T;
00155 double var_calcium_background_current__Cao = var_calcium_dynamics__Cao;
00156 double var_calcium_background_current__E_Ca = ((var_calcium_background_current__R * var_calcium_background_current__T) / (2.0 * var_calcium_background_current__F)) * log(var_calcium_background_current__Cao / var_calcium_background_current__Cai);
00157 double var_T_type_Ca_channel__E_Ca = var_calcium_background_current__E_Ca;
00158 double var_T_type_Ca_channel__i_Ca_T = var_T_type_Ca_channel__g_CaT * var_T_type_Ca_channel__b * var_T_type_Ca_channel__b * var_T_type_Ca_channel__g * (var_T_type_Ca_channel__V - var_T_type_Ca_channel__E_Ca);
00159 double var_membrane__i_Ca_T = var_T_type_Ca_channel__i_Ca_T;
00160 double var_rapid_delayed_rectifier_potassium_current__Ko = var_ionic_concentrations__Ko;
00161 double var_rapid_delayed_rectifier_potassium_current__g_Kr = 0.02614 * sqrt(var_rapid_delayed_rectifier_potassium_current__Ko / 5.4);
00162 double var_rapid_delayed_rectifier_potassium_current__V = var_membrane__V;
00163 double var_rapid_delayed_rectifier_potassium_current__xr = var_rapid_delayed_rectifier_potassium_current_xr_gate__xr;
00164 double var_rapid_delayed_rectifier_potassium_current__Rect = 1.0 / (1.0 + exp((var_rapid_delayed_rectifier_potassium_current__V + 9.0) / 22.4));
00165 double var_time_independent_potassium_current__Ki = var_ionic_concentrations__Ki;
00166 double var_time_independent_potassium_current__R = var_membrane__R;
00167 double var_time_independent_potassium_current__F = var_membrane__F;
00168 double var_time_independent_potassium_current__Ko = var_ionic_concentrations__Ko;
00169 double var_time_independent_potassium_current__T = var_membrane__T;
00170 double var_time_independent_potassium_current__E_K = ((var_time_independent_potassium_current__R * var_time_independent_potassium_current__T) / var_time_independent_potassium_current__F) * log(var_time_independent_potassium_current__Ko / var_time_independent_potassium_current__Ki);
00171 double var_rapid_delayed_rectifier_potassium_current__E_K = var_time_independent_potassium_current__E_K;
00172 double var_rapid_delayed_rectifier_potassium_current__i_Kr = mScaleFactorGkr*var_rapid_delayed_rectifier_potassium_current__g_Kr * var_rapid_delayed_rectifier_potassium_current__xr * var_rapid_delayed_rectifier_potassium_current__Rect * (var_rapid_delayed_rectifier_potassium_current__V - var_rapid_delayed_rectifier_potassium_current__E_K);
00173 double var_membrane__i_Kr = var_rapid_delayed_rectifier_potassium_current__i_Kr;
00174 double var_slow_delayed_rectifier_potassium_current__xs2 = var_slow_delayed_rectifier_potassium_current_xs2_gate__xs2;
00175 double var_slow_delayed_rectifier_potassium_current__Nai = var_ionic_concentrations__Nai;
00176 double var_slow_delayed_rectifier_potassium_current__Nao = var_ionic_concentrations__Nao;
00177 double var_slow_delayed_rectifier_potassium_current__F = var_membrane__F;
00178 const double var_slow_delayed_rectifier_potassium_current__PNaK = 0.01833;
00179 double var_slow_delayed_rectifier_potassium_current__Ko = var_ionic_concentrations__Ko;
00180 double var_slow_delayed_rectifier_potassium_current__R = var_membrane__R;
00181 double var_slow_delayed_rectifier_potassium_current__T = var_membrane__T;
00182 double var_slow_delayed_rectifier_potassium_current__Ki = var_ionic_concentrations__Ki;
00183 double var_slow_delayed_rectifier_potassium_current__E_Ks = ((var_slow_delayed_rectifier_potassium_current__R * var_slow_delayed_rectifier_potassium_current__T) / var_slow_delayed_rectifier_potassium_current__F) * log((var_slow_delayed_rectifier_potassium_current__Ko + (var_slow_delayed_rectifier_potassium_current__PNaK * var_slow_delayed_rectifier_potassium_current__Nao)) / (var_slow_delayed_rectifier_potassium_current__Ki + (var_slow_delayed_rectifier_potassium_current__PNaK * var_slow_delayed_rectifier_potassium_current__Nai)));
00184 double var_slow_delayed_rectifier_potassium_current__xs1 = var_slow_delayed_rectifier_potassium_current_xs1_gate__xs1;
00185 double var_slow_delayed_rectifier_potassium_current__Cai = var_calcium_dynamics__Cai;
00186 double var_slow_delayed_rectifier_potassium_current__g_Ks = 0.433 * (1.0 + (0.6 / (1.0 + pow(3.8e-05 / var_slow_delayed_rectifier_potassium_current__Cai, 1.4))));
00187 double var_slow_delayed_rectifier_potassium_current__V = var_membrane__V;
00188 double var_slow_delayed_rectifier_potassium_current__i_Ks = mScaleFactorGks*var_slow_delayed_rectifier_potassium_current__g_Ks * var_slow_delayed_rectifier_potassium_current__xs1 * var_slow_delayed_rectifier_potassium_current__xs2 * (var_slow_delayed_rectifier_potassium_current__V - var_slow_delayed_rectifier_potassium_current__E_Ks);
00189 double var_membrane__i_Ks = var_slow_delayed_rectifier_potassium_current__i_Ks;
00190 double var_sodium_activated_potassium_current__V = var_membrane__V;
00191 double var_sodium_activated_potassium_current__pov = 0.8 - (0.65 / (1.0 + exp((var_sodium_activated_potassium_current__V + 125.0) / 15.0)));
00192 double var_sodium_activated_potassium_current__g_K_Na = 0.0 * 0.12848;
00193 const double var_sodium_activated_potassium_current__nKNa = 2.8;
00194 double var_sodium_activated_potassium_current__Nai = var_ionic_concentrations__Nai;
00195 const double var_sodium_activated_potassium_current__kdKNa = 66.0;
00196 double var_sodium_activated_potassium_current__pona = 0.85 / (1.0 + pow(var_sodium_activated_potassium_current__kdKNa / var_sodium_activated_potassium_current__Nai, var_sodium_activated_potassium_current__nKNa));
00197 double var_sodium_activated_potassium_current__E_K = var_time_independent_potassium_current__E_K;
00198 double var_sodium_activated_potassium_current__i_K_Na = var_sodium_activated_potassium_current__g_K_Na * var_sodium_activated_potassium_current__pona * var_sodium_activated_potassium_current__pov * (var_sodium_activated_potassium_current__V - var_sodium_activated_potassium_current__E_K);
00199 double var_membrane__i_K_Na = var_sodium_activated_potassium_current__i_K_Na;
00200 double var_ATP_sensitive_potassium_current__V = var_membrane__V;
00201 const double var_ATP_sensitive_potassium_current__nATP = 0.24;
00202 const double var_ATP_sensitive_potassium_current__hATP = 2.0;
00203 const double var_ATP_sensitive_potassium_current__ATPi = 3.0;
00204 const double var_ATP_sensitive_potassium_current__kATP = 0.00025;
00205 double var_ATP_sensitive_potassium_current__pATP = 1.0 / (1.0 + pow(var_ATP_sensitive_potassium_current__ATPi / var_ATP_sensitive_potassium_current__kATP, var_ATP_sensitive_potassium_current__hATP));
00206 const double var_ATP_sensitive_potassium_current__i_K_ATP_on = 1.0;
00207 const double var_ATP_sensitive_potassium_current__nicholsarea = 5e-05;
00208 double var_ATP_sensitive_potassium_current__g_K_ATP = (var_ATP_sensitive_potassium_current__i_K_ATP_on * 0.000193) / var_ATP_sensitive_potassium_current__nicholsarea;
00209 double var_ATP_sensitive_potassium_current__Ko = var_ionic_concentrations__Ko;
00210 double var_ATP_sensitive_potassium_current__GKbaraATP = var_ATP_sensitive_potassium_current__g_K_ATP * var_ATP_sensitive_potassium_current__pATP * pow(var_ATP_sensitive_potassium_current__Ko / 4.0, var_ATP_sensitive_potassium_current__nATP);
00211 double var_ATP_sensitive_potassium_current__E_K = var_time_independent_potassium_current__E_K;
00212 double var_ATP_sensitive_potassium_current__i_K_ATP = var_ATP_sensitive_potassium_current__GKbaraATP * (var_ATP_sensitive_potassium_current__V - var_ATP_sensitive_potassium_current__E_K);
00213 double var_membrane__i_K_ATP = var_ATP_sensitive_potassium_current__i_K_ATP;
00214 double var_transient_outward_current__g_to = mScaleFactorIto* 0.5;
00215 double var_transient_outward_current__V = var_membrane__V;
00216 double var_transient_outward_current__E_K = var_time_independent_potassium_current__E_K;
00217 double var_transient_outward_current__zdv = var_transient_outward_current_zdv_gate__zdv;
00218 double var_transient_outward_current__ydv = var_transient_outward_current_ydv_gate__ydv;
00219 double var_transient_outward_current__rvdv = exp(var_transient_outward_current__V / 100.0);
00220 double var_transient_outward_current__i_to = var_transient_outward_current__g_to * pow(var_transient_outward_current__zdv, 3.0) * var_transient_outward_current__ydv * var_transient_outward_current__rvdv * (var_transient_outward_current__V - var_transient_outward_current__E_K);
00221 double var_membrane__i_to = var_transient_outward_current__i_to;
00222 double var_Na_Ca_exchanger__Nao = var_ionic_concentrations__Nao;
00223 double var_Na_Ca_exchanger__F = var_membrane__F;
00224 const double var_Na_Ca_exchanger__gamma = 0.15;
00225 double var_Na_Ca_exchanger__Nai = var_ionic_concentrations__Nai;
00226 const double var_Na_Ca_exchanger__c1 = 0.00025;
00227 const double var_Na_Ca_exchanger__c2 = 0.0001;
00228 double var_Na_Ca_exchanger__T = var_membrane__T;
00229 double var_Na_Ca_exchanger__Cao = var_calcium_dynamics__Cao;
00230 double var_Na_Ca_exchanger__V = var_membrane__V;
00231 double var_Na_Ca_exchanger__R = var_membrane__R;
00232 double var_Na_Ca_exchanger__Cai = var_calcium_dynamics__Cai;
00233 double var_Na_Ca_exchanger__i_NaCa = (var_Na_Ca_exchanger__c1 * exp(((var_Na_Ca_exchanger__gamma - 1.0) * var_Na_Ca_exchanger__V * var_Na_Ca_exchanger__F) / (var_Na_Ca_exchanger__R * var_Na_Ca_exchanger__T)) * ((exp((var_Na_Ca_exchanger__V * var_Na_Ca_exchanger__F) / (var_Na_Ca_exchanger__R * var_Na_Ca_exchanger__T)) * pow(var_Na_Ca_exchanger__Nai, 3.0) * var_Na_Ca_exchanger__Cao) - (pow(var_Na_Ca_exchanger__Nao, 3.0) * var_Na_Ca_exchanger__Cai))) / (1.0 + (var_Na_Ca_exchanger__c2 * exp(((var_Na_Ca_exchanger__gamma - 1.0) * var_Na_Ca_exchanger__V * var_Na_Ca_exchanger__F) / (var_Na_Ca_exchanger__R * var_Na_Ca_exchanger__T)) * ((exp((var_Na_Ca_exchanger__V * var_Na_Ca_exchanger__F) / (var_Na_Ca_exchanger__R * var_Na_Ca_exchanger__T)) * pow(var_Na_Ca_exchanger__Nai, 3.0) * var_Na_Ca_exchanger__Cao) + (pow(var_Na_Ca_exchanger__Nao, 3.0) * var_Na_Ca_exchanger__Cai))));
00234 double var_membrane__i_NaCa = var_Na_Ca_exchanger__i_NaCa;
00235 double var_time_independent_potassium_current__V = var_membrane__V;
00236 double var_time_independent_potassium_current_K1_gate__V = var_time_independent_potassium_current__V;
00237 double var_time_independent_potassium_current_K1_gate__E_K = var_time_independent_potassium_current__E_K;
00238 double var_time_independent_potassium_current_K1_gate__beta_K1 = (1000.0 * ((0.49124 * exp(0.08032 * ((var_time_independent_potassium_current_K1_gate__V - var_time_independent_potassium_current_K1_gate__E_K) + 5.476))) + exp(0.06175 * ((var_time_independent_potassium_current_K1_gate__V - var_time_independent_potassium_current_K1_gate__E_K) - 594.31)))) / (1.0 + exp((-0.5143) * ((var_time_independent_potassium_current_K1_gate__V - var_time_independent_potassium_current_K1_gate__E_K) + 4.753)));
00239 double var_time_independent_potassium_current_K1_gate__alpha_K1 = 1020.0 / (1.0 + exp(0.2385 * ((var_time_independent_potassium_current_K1_gate__V - var_time_independent_potassium_current_K1_gate__E_K) - 59.215)));
00240 double var_time_independent_potassium_current_K1_gate__K1_infinity = var_time_independent_potassium_current_K1_gate__alpha_K1 / (var_time_independent_potassium_current_K1_gate__alpha_K1 + var_time_independent_potassium_current_K1_gate__beta_K1);
00241 double var_time_independent_potassium_current__K1_infinity = var_time_independent_potassium_current_K1_gate__K1_infinity;
00242 double var_time_independent_potassium_current__g_K1 = 0.75 * sqrt(var_time_independent_potassium_current__Ko / 5.4);
00243 double var_time_independent_potassium_current__i_K1 = var_time_independent_potassium_current__g_K1 * var_time_independent_potassium_current__K1_infinity * (var_time_independent_potassium_current__V - var_time_independent_potassium_current__E_K);
00244 double var_membrane__i_K1 = var_time_independent_potassium_current__i_K1;
00245 const double var_plateau_potassium_current__g_Kp = 0.00552;
00246 double var_plateau_potassium_current__V = var_membrane__V;
00247 double var_plateau_potassium_current__Kp = 1.0 / (1.0 + exp((7.488 - var_plateau_potassium_current__V) / 5.98));
00248 double var_plateau_potassium_current__E_K = var_time_independent_potassium_current__E_K;
00249 double var_plateau_potassium_current__i_Kp = var_plateau_potassium_current__g_Kp * var_plateau_potassium_current__Kp * (var_plateau_potassium_current__V - var_plateau_potassium_current__E_K);
00250 double var_membrane__i_Kp = var_plateau_potassium_current__i_Kp;
00251 const double var_sarcolemmal_calcium_pump__I_pCa = 1.15;
00252 double var_sarcolemmal_calcium_pump__Cai = var_calcium_dynamics__Cai;
00253 const double var_sarcolemmal_calcium_pump__K_mpCa = 0.0005;
00254 double var_sarcolemmal_calcium_pump__i_p_Ca = (var_sarcolemmal_calcium_pump__I_pCa * var_sarcolemmal_calcium_pump__Cai) / (var_sarcolemmal_calcium_pump__K_mpCa + var_sarcolemmal_calcium_pump__Cai);
00255 double var_membrane__i_p_Ca = var_sarcolemmal_calcium_pump__i_p_Ca;
00256 const double var_sodium_background_current__g_Nab = 0.004;
00257 double var_sodium_background_current__V = var_membrane__V;
00258 double var_sodium_background_current__E_Na = var_fast_sodium_current__E_Na;
00259 double var_sodium_background_current__i_Na_b = var_sodium_background_current__g_Nab * (var_sodium_background_current__V - var_sodium_background_current__E_Na);
00260 double var_membrane__i_Na_b = var_sodium_background_current__i_Na_b;
00261 const double var_calcium_background_current__g_Cab = 0.003016;
00262 double var_calcium_background_current__V = var_membrane__V;
00263 double var_calcium_background_current__i_Ca_b = var_calcium_background_current__g_Cab * (var_calcium_background_current__V - var_calcium_background_current__E_Ca);
00264 double var_membrane__i_Ca_b = var_calcium_background_current__i_Ca_b;
00265 double var_sodium_potassium_pump__Ko = var_ionic_concentrations__Ko;
00266 const double var_sodium_potassium_pump__K_mNai = 10.0;
00267 double var_sodium_potassium_pump__Nai = var_ionic_concentrations__Nai;
00268 double var_sodium_potassium_pump__V = var_membrane__V;
00269 double var_sodium_potassium_pump__F = var_membrane__F;
00270 double var_sodium_potassium_pump__T = var_membrane__T;
00271 double var_sodium_potassium_pump__Nao = var_ionic_concentrations__Nao;
00272 double var_sodium_potassium_pump__sigma = (1.0 / 7.0) * (exp(var_sodium_potassium_pump__Nao / 67.3) - 1.0);
00273 double var_sodium_potassium_pump__R = var_membrane__R;
00274 double var_sodium_potassium_pump__f_NaK = 1.0 / (1.0 + (0.1245 * exp(((-0.1) * var_sodium_potassium_pump__V * var_sodium_potassium_pump__F) / (var_sodium_potassium_pump__R * var_sodium_potassium_pump__T))) + (0.0365 * var_sodium_potassium_pump__sigma * exp(((-var_sodium_potassium_pump__V) * var_sodium_potassium_pump__F) / (var_sodium_potassium_pump__R * var_sodium_potassium_pump__T))));
00275 const double var_sodium_potassium_pump__I_NaK = 2.25;
00276 const double var_sodium_potassium_pump__K_mKo = 1.5;
00277 double var_sodium_potassium_pump__i_NaK = (((var_sodium_potassium_pump__I_NaK * var_sodium_potassium_pump__f_NaK * 1.0) / (1.0 + pow(var_sodium_potassium_pump__K_mNai / var_sodium_potassium_pump__Nai, 2.0))) * var_sodium_potassium_pump__Ko) / (var_sodium_potassium_pump__Ko + var_sodium_potassium_pump__K_mKo);
00278 double var_membrane__i_NaK = var_sodium_potassium_pump__i_NaK;
00279 double var_non_specific_calcium_activated_current__F = var_membrane__F;
00280 double var_non_specific_calcium_activated_current__R = var_membrane__R;
00281 double var_non_specific_calcium_activated_current__T = var_membrane__T;
00282 double var_non_specific_calcium_activated_current__V = var_membrane__V;
00283 double var_non_specific_calcium_activated_current__P_ns_Ca = 0.0 * 1.75e-07;
00284 double var_non_specific_calcium_activated_current__Nao = var_ionic_concentrations__Nao;
00285 double var_non_specific_calcium_activated_current__gamma_Nai = var_L_type_Ca_channel__gamma_Nai;
00286 double var_non_specific_calcium_activated_current__gamma_Nao = var_L_type_Ca_channel__gamma_Nao;
00287 double var_non_specific_calcium_activated_current__Nai = var_ionic_concentrations__Nai;
00288 double var_non_specific_calcium_activated_current__I_ns_Na = (((var_non_specific_calcium_activated_current__P_ns_Ca * pow(1.0, 2.0) * var_non_specific_calcium_activated_current__V * pow(var_non_specific_calcium_activated_current__F, 2.0)) / (var_non_specific_calcium_activated_current__R * var_non_specific_calcium_activated_current__T)) * ((var_non_specific_calcium_activated_current__gamma_Nai * var_non_specific_calcium_activated_current__Nai * exp((1.0 * var_non_specific_calcium_activated_current__V * var_non_specific_calcium_activated_current__F) / (var_non_specific_calcium_activated_current__R * var_non_specific_calcium_activated_current__T))) - (var_non_specific_calcium_activated_current__gamma_Nao * var_non_specific_calcium_activated_current__Nao))) / (exp((1.0 * var_non_specific_calcium_activated_current__V * var_non_specific_calcium_activated_current__F) / (var_non_specific_calcium_activated_current__R * var_non_specific_calcium_activated_current__T)) - 1.0);
00289 const double var_non_specific_calcium_activated_current__K_m_ns_Ca = 0.0012;
00290 double var_non_specific_calcium_activated_current__Cai = var_calcium_dynamics__Cai;
00291 double var_non_specific_calcium_activated_current__i_ns_Na = (var_non_specific_calcium_activated_current__I_ns_Na * 1.0) / (1.0 + pow(var_non_specific_calcium_activated_current__K_m_ns_Ca / var_non_specific_calcium_activated_current__Cai, 3.0));
00292 double var_non_specific_calcium_activated_current__Ko = var_ionic_concentrations__Ko;
00293 double var_non_specific_calcium_activated_current__Ki = var_ionic_concentrations__Ki;
00294 double var_non_specific_calcium_activated_current__gamma_Ko = var_L_type_Ca_channel__gamma_Ko;
00295 double var_non_specific_calcium_activated_current__gamma_Ki = var_L_type_Ca_channel__gamma_Ki;
00296 double var_non_specific_calcium_activated_current__I_ns_K = (((var_non_specific_calcium_activated_current__P_ns_Ca * pow(1.0, 2.0) * var_non_specific_calcium_activated_current__V * pow(var_non_specific_calcium_activated_current__F, 2.0)) / (var_non_specific_calcium_activated_current__R * var_non_specific_calcium_activated_current__T)) * ((var_non_specific_calcium_activated_current__gamma_Ki * var_non_specific_calcium_activated_current__Ki * exp((1.0 * var_non_specific_calcium_activated_current__V * var_non_specific_calcium_activated_current__F) / (var_non_specific_calcium_activated_current__R * var_non_specific_calcium_activated_current__T))) - (var_non_specific_calcium_activated_current__gamma_Ko * var_non_specific_calcium_activated_current__Ko))) / (exp((1.0 * var_non_specific_calcium_activated_current__V * var_non_specific_calcium_activated_current__F) / (var_non_specific_calcium_activated_current__R * var_non_specific_calcium_activated_current__T)) - 1.0);
00297 double var_non_specific_calcium_activated_current__i_ns_K = (var_non_specific_calcium_activated_current__I_ns_K * 1.0) / (1.0 + pow(var_non_specific_calcium_activated_current__K_m_ns_Ca / var_non_specific_calcium_activated_current__Cai, 3.0));
00298 double var_non_specific_calcium_activated_current__i_ns_Ca = var_non_specific_calcium_activated_current__i_ns_Na + var_non_specific_calcium_activated_current__i_ns_K;
00299 double var_membrane__i_ns_Ca = var_non_specific_calcium_activated_current__i_ns_Ca;
00300
00301 return var_membrane__i_Na+var_membrane__i_Ca_L+var_membrane__i_Ca_T+var_membrane__i_Kr+var_membrane__i_Ks+var_membrane__i_K_Na+var_membrane__i_K_ATP+var_membrane__i_to+var_membrane__i_NaCa+var_membrane__i_K1+var_membrane__i_Kp+var_membrane__i_p_Ca+var_membrane__i_Na_b+var_membrane__i_Ca_b+var_membrane__i_NaK+var_membrane__i_ns_Ca;
00302 }
00303
00304 void EvaluateYDerivatives (
00305 double var_environment__time,
00306 const std::vector<double> &rY,
00307 std::vector<double> &rDY)
00308 {
00309
00310
00311 var_environment__time *= 1e-3;
00312 double var_membrane__V = rY[0];
00313
00314 double var_fast_sodium_current_m_gate__m = rY[1];
00315
00316 double var_fast_sodium_current_h_gate__h = rY[2];
00317
00318 double var_fast_sodium_current_j_gate__j = rY[3];
00319
00320 double var_L_type_Ca_channel_d_gate__d = rY[4];
00321
00322 double var_L_type_Ca_channel_f_gate__f = rY[5];
00323
00324 double var_T_type_Ca_channel_b_gate__b = rY[6];
00325
00326 double var_T_type_Ca_channel_g_gate__g = rY[7];
00327
00328 double var_rapid_delayed_rectifier_potassium_current_xr_gate__xr = rY[8];
00329
00330 double var_slow_delayed_rectifier_potassium_current_xs1_gate__xs1 = rY[9];
00331
00332 double var_slow_delayed_rectifier_potassium_current_xs2_gate__xs2 = rY[10];
00333
00334 double var_transient_outward_current_zdv_gate__zdv = rY[11];
00335
00336 double var_transient_outward_current_ydv_gate__ydv = rY[12];
00337
00338 double var_calcium_dynamics__Cai = rY[13];
00339
00340 double var_calcium_dynamics__Ca_JSR = rY[14];
00341
00342 double var_calcium_dynamics__Ca_NSR = rY[15];
00343
00344 double var_calcium_dynamics__APtrack = rY[16];
00345
00346 double var_calcium_dynamics__APtrack2 = rY[17];
00347
00348 double var_calcium_dynamics__APtrack3 = rY[18];
00349
00350 double var_calcium_dynamics__Cainfluxtrack = rY[19];
00351
00352 double var_calcium_dynamics__OVRLDtrack = rY[20];
00353
00354 double var_calcium_dynamics__OVRLDtrack2 = rY[21];
00355
00356 double var_calcium_dynamics__OVRLDtrack3 = rY[22];
00357
00358 double var_ionic_concentrations__Nai = rY[23];
00359
00360 double var_ionic_concentrations__Ki = rY[24];
00361
00362
00363
00364
00365 const double var_membrane__R = 8314.0;
00366 const double var_membrane__T = 310.0;
00367 const double var_membrane__F = 96485.0;
00368 const double var_membrane__Cm = 0.001;
00369
00370
00371
00372
00373
00374
00375
00376 double var_membrane__I_st = GetStimulus(var_environment__time*1000);
00377 double var_fast_sodium_current__j = var_fast_sodium_current_j_gate__j;
00378 double var_fast_sodium_current__h = var_fast_sodium_current_h_gate__h;
00379 const double var_fast_sodium_current__g_Na = 16.0;
00380 double var_fast_sodium_current__m = var_fast_sodium_current_m_gate__m;
00381 double var_fast_sodium_current__V = var_membrane__V;
00382 double var_fast_sodium_current__R = var_membrane__R;
00383 double var_fast_sodium_current__F = var_membrane__F;
00384 const double var_ionic_concentrations__Nao = 132.0;
00385 double var_fast_sodium_current__Nao = var_ionic_concentrations__Nao;
00386 double var_fast_sodium_current__Nai = var_ionic_concentrations__Nai;
00387 double var_fast_sodium_current__T = var_membrane__T;
00388 double var_fast_sodium_current__E_Na = ((var_fast_sodium_current__R * var_fast_sodium_current__T) / var_fast_sodium_current__F) * log(var_fast_sodium_current__Nao / var_fast_sodium_current__Nai);
00389 double var_fast_sodium_current__i_Na = var_fast_sodium_current__g_Na * pow(var_fast_sodium_current__m, 3.0) * var_fast_sodium_current__h * var_fast_sodium_current__j * (var_fast_sodium_current__V - var_fast_sodium_current__E_Na);
00390 double var_membrane__i_Na = var_fast_sodium_current__i_Na;
00391 double var_L_type_Ca_channel__d = var_L_type_Ca_channel_d_gate__d;
00392 double var_L_type_Ca_channel__f = var_L_type_Ca_channel_f_gate__f;
00393 const double var_L_type_Ca_channel_f_Ca_gate__Km_Ca = 0.0006;
00394 double var_L_type_Ca_channel__Cai = var_calcium_dynamics__Cai;
00395 double var_L_type_Ca_channel_f_Ca_gate__Cai = var_L_type_Ca_channel__Cai;
00396 double var_L_type_Ca_channel_f_Ca_gate__f_Ca = 1.0 / (1.0 + (var_L_type_Ca_channel_f_Ca_gate__Cai / var_L_type_Ca_channel_f_Ca_gate__Km_Ca));
00397 double var_L_type_Ca_channel__f_Ca = var_L_type_Ca_channel_f_Ca_gate__f_Ca;
00398 const double var_L_type_Ca_channel__gamma_Cai = 1.0;
00399 const double var_L_type_Ca_channel__gamma_Cao = 0.341;
00400 const double var_calcium_dynamics__Cao = 1.8;
00401 double var_L_type_Ca_channel__Cao = var_calcium_dynamics__Cao;
00402 double var_L_type_Ca_channel__F = var_membrane__F;
00403 const double var_L_type_Ca_channel__P_Ca = 0.00054;
00404 double var_L_type_Ca_channel__T = var_membrane__T;
00405 double var_L_type_Ca_channel__V = var_membrane__V;
00406 double var_L_type_Ca_channel__R = var_membrane__R;
00407 double var_L_type_Ca_channel__I_CaCa = (((var_L_type_Ca_channel__P_Ca * pow(2.0, 2.0) * var_L_type_Ca_channel__V * pow(var_L_type_Ca_channel__F, 2.0)) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T)) * ((var_L_type_Ca_channel__gamma_Cai * var_L_type_Ca_channel__Cai * exp((2.0 * var_L_type_Ca_channel__V * var_L_type_Ca_channel__F) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T))) - (var_L_type_Ca_channel__gamma_Cao * var_L_type_Ca_channel__Cao))) / (exp((2.0 * var_L_type_Ca_channel__V * var_L_type_Ca_channel__F) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T)) - 1.0);
00408 double var_L_type_Ca_channel__i_CaCa = var_L_type_Ca_channel__d * var_L_type_Ca_channel__f * var_L_type_Ca_channel__f_Ca * var_L_type_Ca_channel__I_CaCa;
00409 const double var_L_type_Ca_channel__P_Na = 6.75e-07;
00410 const double var_L_type_Ca_channel__gamma_Nao = 0.75;
00411 double var_L_type_Ca_channel__Nao = var_ionic_concentrations__Nao;
00412 double var_L_type_Ca_channel__Nai = var_ionic_concentrations__Nai;
00413 const double var_L_type_Ca_channel__gamma_Nai = 0.75;
00414 double var_L_type_Ca_channel__I_CaNa = (((var_L_type_Ca_channel__P_Na * pow(1.0, 2.0) * var_L_type_Ca_channel__V * pow(var_L_type_Ca_channel__F, 2.0)) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T)) * ((var_L_type_Ca_channel__gamma_Nai * var_L_type_Ca_channel__Nai * exp((1.0 * var_L_type_Ca_channel__V * var_L_type_Ca_channel__F) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T))) - (var_L_type_Ca_channel__gamma_Nao * var_L_type_Ca_channel__Nao))) / (exp((1.0 * var_L_type_Ca_channel__V * var_L_type_Ca_channel__F) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T)) - 1.0);
00415 double var_L_type_Ca_channel__i_CaNa = var_L_type_Ca_channel__d * var_L_type_Ca_channel__f * var_L_type_Ca_channel__f_Ca * var_L_type_Ca_channel__I_CaNa;
00416 const double var_ionic_concentrations__Ko = 4.5;
00417 double var_L_type_Ca_channel__Ko = var_ionic_concentrations__Ko;
00418 double var_L_type_Ca_channel__Ki = var_ionic_concentrations__Ki;
00419 const double var_L_type_Ca_channel__P_K = 1.93e-07;
00420 const double var_L_type_Ca_channel__gamma_Ki = 0.75;
00421 const double var_L_type_Ca_channel__gamma_Ko = 0.75;
00422 double var_L_type_Ca_channel__I_CaK = (((var_L_type_Ca_channel__P_K * pow(1.0, 2.0) * var_L_type_Ca_channel__V * pow(var_L_type_Ca_channel__F, 2.0)) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T)) * ((var_L_type_Ca_channel__gamma_Ki * var_L_type_Ca_channel__Ki * exp((1.0 * var_L_type_Ca_channel__V * var_L_type_Ca_channel__F) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T))) - (var_L_type_Ca_channel__gamma_Ko * var_L_type_Ca_channel__Ko))) / (exp((1.0 * var_L_type_Ca_channel__V * var_L_type_Ca_channel__F) / (var_L_type_Ca_channel__R * var_L_type_Ca_channel__T)) - 1.0);
00423 double var_L_type_Ca_channel__i_CaK = var_L_type_Ca_channel__d * var_L_type_Ca_channel__f * var_L_type_Ca_channel__f_Ca * var_L_type_Ca_channel__I_CaK;
00424 double var_L_type_Ca_channel__i_Ca_L = var_L_type_Ca_channel__i_CaCa + var_L_type_Ca_channel__i_CaK + var_L_type_Ca_channel__i_CaNa;
00425 double var_membrane__i_Ca_L = var_L_type_Ca_channel__i_Ca_L;
00426 double var_T_type_Ca_channel__V = var_membrane__V;
00427 double var_T_type_Ca_channel__g = var_T_type_Ca_channel_g_gate__g;
00428 const double var_T_type_Ca_channel__g_CaT = 0.05;
00429 double var_T_type_Ca_channel__b = var_T_type_Ca_channel_b_gate__b;
00430 double var_calcium_background_current__R = var_membrane__R;
00431 double var_calcium_background_current__Cai = var_calcium_dynamics__Cai;
00432 double var_calcium_background_current__F = var_membrane__F;
00433 double var_calcium_background_current__T = var_membrane__T;
00434 double var_calcium_background_current__Cao = var_calcium_dynamics__Cao;
00435 double var_calcium_background_current__E_Ca = ((var_calcium_background_current__R * var_calcium_background_current__T) / (2.0 * var_calcium_background_current__F)) * log(var_calcium_background_current__Cao / var_calcium_background_current__Cai);
00436 double var_T_type_Ca_channel__E_Ca = var_calcium_background_current__E_Ca;
00437 double var_T_type_Ca_channel__i_Ca_T = var_T_type_Ca_channel__g_CaT * var_T_type_Ca_channel__b * var_T_type_Ca_channel__b * var_T_type_Ca_channel__g * (var_T_type_Ca_channel__V - var_T_type_Ca_channel__E_Ca);
00438 double var_membrane__i_Ca_T = var_T_type_Ca_channel__i_Ca_T;
00439 double var_rapid_delayed_rectifier_potassium_current__Ko = var_ionic_concentrations__Ko;
00440 double var_rapid_delayed_rectifier_potassium_current__g_Kr = 0.02614 * sqrt(var_rapid_delayed_rectifier_potassium_current__Ko / 5.4);
00441 double var_rapid_delayed_rectifier_potassium_current__V = var_membrane__V;
00442 double var_rapid_delayed_rectifier_potassium_current__xr = var_rapid_delayed_rectifier_potassium_current_xr_gate__xr;
00443 double var_rapid_delayed_rectifier_potassium_current__Rect = 1.0 / (1.0 + exp((var_rapid_delayed_rectifier_potassium_current__V + 9.0) / 22.4));
00444 double var_time_independent_potassium_current__Ki = var_ionic_concentrations__Ki;
00445 double var_time_independent_potassium_current__R = var_membrane__R;
00446 double var_time_independent_potassium_current__F = var_membrane__F;
00447 double var_time_independent_potassium_current__Ko = var_ionic_concentrations__Ko;
00448 double var_time_independent_potassium_current__T = var_membrane__T;
00449 double var_time_independent_potassium_current__E_K = ((var_time_independent_potassium_current__R * var_time_independent_potassium_current__T) / var_time_independent_potassium_current__F) * log(var_time_independent_potassium_current__Ko / var_time_independent_potassium_current__Ki);
00450 double var_rapid_delayed_rectifier_potassium_current__E_K = var_time_independent_potassium_current__E_K;
00451 double var_rapid_delayed_rectifier_potassium_current__i_Kr = mScaleFactorGkr*var_rapid_delayed_rectifier_potassium_current__g_Kr * var_rapid_delayed_rectifier_potassium_current__xr * var_rapid_delayed_rectifier_potassium_current__Rect * (var_rapid_delayed_rectifier_potassium_current__V - var_rapid_delayed_rectifier_potassium_current__E_K);
00452 double var_membrane__i_Kr = var_rapid_delayed_rectifier_potassium_current__i_Kr;
00453 double var_slow_delayed_rectifier_potassium_current__xs2 = var_slow_delayed_rectifier_potassium_current_xs2_gate__xs2;
00454 double var_slow_delayed_rectifier_potassium_current__Nai = var_ionic_concentrations__Nai;
00455 double var_slow_delayed_rectifier_potassium_current__Nao = var_ionic_concentrations__Nao;
00456 double var_slow_delayed_rectifier_potassium_current__F = var_membrane__F;
00457 const double var_slow_delayed_rectifier_potassium_current__PNaK = 0.01833;
00458 double var_slow_delayed_rectifier_potassium_current__Ko = var_ionic_concentrations__Ko;
00459 double var_slow_delayed_rectifier_potassium_current__R = var_membrane__R;
00460 double var_slow_delayed_rectifier_potassium_current__T = var_membrane__T;
00461 double var_slow_delayed_rectifier_potassium_current__Ki = var_ionic_concentrations__Ki;
00462 double var_slow_delayed_rectifier_potassium_current__E_Ks = ((var_slow_delayed_rectifier_potassium_current__R * var_slow_delayed_rectifier_potassium_current__T) / var_slow_delayed_rectifier_potassium_current__F) * log((var_slow_delayed_rectifier_potassium_current__Ko + (var_slow_delayed_rectifier_potassium_current__PNaK * var_slow_delayed_rectifier_potassium_current__Nao)) / (var_slow_delayed_rectifier_potassium_current__Ki + (var_slow_delayed_rectifier_potassium_current__PNaK * var_slow_delayed_rectifier_potassium_current__Nai)));
00463 double var_slow_delayed_rectifier_potassium_current__xs1 = var_slow_delayed_rectifier_potassium_current_xs1_gate__xs1;
00464 double var_slow_delayed_rectifier_potassium_current__Cai = var_calcium_dynamics__Cai;
00465 double var_slow_delayed_rectifier_potassium_current__g_Ks = 0.433 * (1.0 + (0.6 / (1.0 + pow(3.8e-05 / var_slow_delayed_rectifier_potassium_current__Cai, 1.4))));
00466 double var_slow_delayed_rectifier_potassium_current__V = var_membrane__V;
00467 double var_slow_delayed_rectifier_potassium_current__i_Ks = mScaleFactorGks*var_slow_delayed_rectifier_potassium_current__g_Ks * var_slow_delayed_rectifier_potassium_current__xs1 * var_slow_delayed_rectifier_potassium_current__xs2 * (var_slow_delayed_rectifier_potassium_current__V - var_slow_delayed_rectifier_potassium_current__E_Ks);
00468 double var_membrane__i_Ks = var_slow_delayed_rectifier_potassium_current__i_Ks;
00469 double var_sodium_activated_potassium_current__V = var_membrane__V;
00470 double var_sodium_activated_potassium_current__pov = 0.8 - (0.65 / (1.0 + exp((var_sodium_activated_potassium_current__V + 125.0) / 15.0)));
00471 double var_sodium_activated_potassium_current__g_K_Na = 0.0 * 0.12848;
00472 const double var_sodium_activated_potassium_current__nKNa = 2.8;
00473 double var_sodium_activated_potassium_current__Nai = var_ionic_concentrations__Nai;
00474 const double var_sodium_activated_potassium_current__kdKNa = 66.0;
00475 double var_sodium_activated_potassium_current__pona = 0.85 / (1.0 + pow(var_sodium_activated_potassium_current__kdKNa / var_sodium_activated_potassium_current__Nai, var_sodium_activated_potassium_current__nKNa));
00476 double var_sodium_activated_potassium_current__E_K = var_time_independent_potassium_current__E_K;
00477 double var_sodium_activated_potassium_current__i_K_Na = var_sodium_activated_potassium_current__g_K_Na * var_sodium_activated_potassium_current__pona * var_sodium_activated_potassium_current__pov * (var_sodium_activated_potassium_current__V - var_sodium_activated_potassium_current__E_K);
00478 double var_membrane__i_K_Na = var_sodium_activated_potassium_current__i_K_Na;
00479 double var_ATP_sensitive_potassium_current__V = var_membrane__V;
00480 const double var_ATP_sensitive_potassium_current__nATP = 0.24;
00481 const double var_ATP_sensitive_potassium_current__hATP = 2.0;
00482 const double var_ATP_sensitive_potassium_current__ATPi = 3.0;
00483 const double var_ATP_sensitive_potassium_current__kATP = 0.00025;
00484 double var_ATP_sensitive_potassium_current__pATP = 1.0 / (1.0 + pow(var_ATP_sensitive_potassium_current__ATPi / var_ATP_sensitive_potassium_current__kATP, var_ATP_sensitive_potassium_current__hATP));
00485 const double var_ATP_sensitive_potassium_current__i_K_ATP_on = 1.0;
00486 const double var_ATP_sensitive_potassium_current__nicholsarea = 5e-05;
00487 double var_ATP_sensitive_potassium_current__g_K_ATP = (var_ATP_sensitive_potassium_current__i_K_ATP_on * 0.000193) / var_ATP_sensitive_potassium_current__nicholsarea;
00488 double var_ATP_sensitive_potassium_current__Ko = var_ionic_concentrations__Ko;
00489 double var_ATP_sensitive_potassium_current__GKbaraATP = var_ATP_sensitive_potassium_current__g_K_ATP * var_ATP_sensitive_potassium_current__pATP * pow(var_ATP_sensitive_potassium_current__Ko / 4.0, var_ATP_sensitive_potassium_current__nATP);
00490 double var_ATP_sensitive_potassium_current__E_K = var_time_independent_potassium_current__E_K;
00491 double var_ATP_sensitive_potassium_current__i_K_ATP = var_ATP_sensitive_potassium_current__GKbaraATP * (var_ATP_sensitive_potassium_current__V - var_ATP_sensitive_potassium_current__E_K);
00492 double var_membrane__i_K_ATP = var_ATP_sensitive_potassium_current__i_K_ATP;
00493 double var_transient_outward_current__g_to = mScaleFactorIto* 0.5;
00494 double var_transient_outward_current__V = var_membrane__V;
00495 double var_transient_outward_current__E_K = var_time_independent_potassium_current__E_K;
00496 double var_transient_outward_current__zdv = var_transient_outward_current_zdv_gate__zdv;
00497 double var_transient_outward_current__ydv = var_transient_outward_current_ydv_gate__ydv;
00498 double var_transient_outward_current__rvdv = exp(var_transient_outward_current__V / 100.0);
00499 double var_transient_outward_current__i_to = var_transient_outward_current__g_to * pow(var_transient_outward_current__zdv, 3.0) * var_transient_outward_current__ydv * var_transient_outward_current__rvdv * (var_transient_outward_current__V - var_transient_outward_current__E_K);
00500 double var_membrane__i_to = var_transient_outward_current__i_to;
00501 double var_Na_Ca_exchanger__Nao = var_ionic_concentrations__Nao;
00502 double var_Na_Ca_exchanger__F = var_membrane__F;
00503 const double var_Na_Ca_exchanger__gamma = 0.15;
00504 double var_Na_Ca_exchanger__Nai = var_ionic_concentrations__Nai;
00505 const double var_Na_Ca_exchanger__c1 = 0.00025;
00506 const double var_Na_Ca_exchanger__c2 = 0.0001;
00507 double var_Na_Ca_exchanger__T = var_membrane__T;
00508 double var_Na_Ca_exchanger__Cao = var_calcium_dynamics__Cao;
00509 double var_Na_Ca_exchanger__V = var_membrane__V;
00510 double var_Na_Ca_exchanger__R = var_membrane__R;
00511 double var_Na_Ca_exchanger__Cai = var_calcium_dynamics__Cai;
00512 double var_Na_Ca_exchanger__i_NaCa = (var_Na_Ca_exchanger__c1 * exp(((var_Na_Ca_exchanger__gamma - 1.0) * var_Na_Ca_exchanger__V * var_Na_Ca_exchanger__F) / (var_Na_Ca_exchanger__R * var_Na_Ca_exchanger__T)) * ((exp((var_Na_Ca_exchanger__V * var_Na_Ca_exchanger__F) / (var_Na_Ca_exchanger__R * var_Na_Ca_exchanger__T)) * pow(var_Na_Ca_exchanger__Nai, 3.0) * var_Na_Ca_exchanger__Cao) - (pow(var_Na_Ca_exchanger__Nao, 3.0) * var_Na_Ca_exchanger__Cai))) / (1.0 + (var_Na_Ca_exchanger__c2 * exp(((var_Na_Ca_exchanger__gamma - 1.0) * var_Na_Ca_exchanger__V * var_Na_Ca_exchanger__F) / (var_Na_Ca_exchanger__R * var_Na_Ca_exchanger__T)) * ((exp((var_Na_Ca_exchanger__V * var_Na_Ca_exchanger__F) / (var_Na_Ca_exchanger__R * var_Na_Ca_exchanger__T)) * pow(var_Na_Ca_exchanger__Nai, 3.0) * var_Na_Ca_exchanger__Cao) + (pow(var_Na_Ca_exchanger__Nao, 3.0) * var_Na_Ca_exchanger__Cai))));
00513 double var_membrane__i_NaCa = var_Na_Ca_exchanger__i_NaCa;
00514 double var_time_independent_potassium_current__V = var_membrane__V;
00515 double var_time_independent_potassium_current_K1_gate__V = var_time_independent_potassium_current__V;
00516 double var_time_independent_potassium_current_K1_gate__E_K = var_time_independent_potassium_current__E_K;
00517 double var_time_independent_potassium_current_K1_gate__beta_K1 = (1000.0 * ((0.49124 * exp(0.08032 * ((var_time_independent_potassium_current_K1_gate__V - var_time_independent_potassium_current_K1_gate__E_K) + 5.476))) + exp(0.06175 * ((var_time_independent_potassium_current_K1_gate__V - var_time_independent_potassium_current_K1_gate__E_K) - 594.31)))) / (1.0 + exp((-0.5143) * ((var_time_independent_potassium_current_K1_gate__V - var_time_independent_potassium_current_K1_gate__E_K) + 4.753)));
00518 double var_time_independent_potassium_current_K1_gate__alpha_K1 = 1020.0 / (1.0 + exp(0.2385 * ((var_time_independent_potassium_current_K1_gate__V - var_time_independent_potassium_current_K1_gate__E_K) - 59.215)));
00519 double var_time_independent_potassium_current_K1_gate__K1_infinity = var_time_independent_potassium_current_K1_gate__alpha_K1 / (var_time_independent_potassium_current_K1_gate__alpha_K1 + var_time_independent_potassium_current_K1_gate__beta_K1);
00520 double var_time_independent_potassium_current__K1_infinity = var_time_independent_potassium_current_K1_gate__K1_infinity;
00521 double var_time_independent_potassium_current__g_K1 = 0.75 * sqrt(var_time_independent_potassium_current__Ko / 5.4);
00522 double var_time_independent_potassium_current__i_K1 = var_time_independent_potassium_current__g_K1 * var_time_independent_potassium_current__K1_infinity * (var_time_independent_potassium_current__V - var_time_independent_potassium_current__E_K);
00523 double var_membrane__i_K1 = var_time_independent_potassium_current__i_K1;
00524 const double var_plateau_potassium_current__g_Kp = 0.00552;
00525 double var_plateau_potassium_current__V = var_membrane__V;
00526 double var_plateau_potassium_current__Kp = 1.0 / (1.0 + exp((7.488 - var_plateau_potassium_current__V) / 5.98));
00527 double var_plateau_potassium_current__E_K = var_time_independent_potassium_current__E_K;
00528 double var_plateau_potassium_current__i_Kp = var_plateau_potassium_current__g_Kp * var_plateau_potassium_current__Kp * (var_plateau_potassium_current__V - var_plateau_potassium_current__E_K);
00529 double var_membrane__i_Kp = var_plateau_potassium_current__i_Kp;
00530 const double var_sarcolemmal_calcium_pump__I_pCa = 1.15;
00531 double var_sarcolemmal_calcium_pump__Cai = var_calcium_dynamics__Cai;
00532 const double var_sarcolemmal_calcium_pump__K_mpCa = 0.0005;
00533 double var_sarcolemmal_calcium_pump__i_p_Ca = (var_sarcolemmal_calcium_pump__I_pCa * var_sarcolemmal_calcium_pump__Cai) / (var_sarcolemmal_calcium_pump__K_mpCa + var_sarcolemmal_calcium_pump__Cai);
00534 double var_membrane__i_p_Ca = var_sarcolemmal_calcium_pump__i_p_Ca;
00535 const double var_sodium_background_current__g_Nab = 0.004;
00536 double var_sodium_background_current__V = var_membrane__V;
00537 double var_sodium_background_current__E_Na = var_fast_sodium_current__E_Na;
00538 double var_sodium_background_current__i_Na_b = var_sodium_background_current__g_Nab * (var_sodium_background_current__V - var_sodium_background_current__E_Na);
00539 double var_membrane__i_Na_b = var_sodium_background_current__i_Na_b;
00540 const double var_calcium_background_current__g_Cab = 0.003016;
00541 double var_calcium_background_current__V = var_membrane__V;
00542 double var_calcium_background_current__i_Ca_b = var_calcium_background_current__g_Cab * (var_calcium_background_current__V - var_calcium_background_current__E_Ca);
00543 double var_membrane__i_Ca_b = var_calcium_background_current__i_Ca_b;
00544 double var_sodium_potassium_pump__Ko = var_ionic_concentrations__Ko;
00545 const double var_sodium_potassium_pump__K_mNai = 10.0;
00546 double var_sodium_potassium_pump__Nai = var_ionic_concentrations__Nai;
00547 double var_sodium_potassium_pump__V = var_membrane__V;
00548 double var_sodium_potassium_pump__F = var_membrane__F;
00549 double var_sodium_potassium_pump__T = var_membrane__T;
00550 double var_sodium_potassium_pump__Nao = var_ionic_concentrations__Nao;
00551 double var_sodium_potassium_pump__sigma = (1.0 / 7.0) * (exp(var_sodium_potassium_pump__Nao / 67.3) - 1.0);
00552 double var_sodium_potassium_pump__R = var_membrane__R;
00553 double var_sodium_potassium_pump__f_NaK = 1.0 / (1.0 + (0.1245 * exp(((-0.1) * var_sodium_potassium_pump__V * var_sodium_potassium_pump__F) / (var_sodium_potassium_pump__R * var_sodium_potassium_pump__T))) + (0.0365 * var_sodium_potassium_pump__sigma * exp(((-var_sodium_potassium_pump__V) * var_sodium_potassium_pump__F) / (var_sodium_potassium_pump__R * var_sodium_potassium_pump__T))));
00554 const double var_sodium_potassium_pump__I_NaK = 2.25;
00555 const double var_sodium_potassium_pump__K_mKo = 1.5;
00556 double var_sodium_potassium_pump__i_NaK = (((var_sodium_potassium_pump__I_NaK * var_sodium_potassium_pump__f_NaK * 1.0) / (1.0 + pow(var_sodium_potassium_pump__K_mNai / var_sodium_potassium_pump__Nai, 2.0))) * var_sodium_potassium_pump__Ko) / (var_sodium_potassium_pump__Ko + var_sodium_potassium_pump__K_mKo);
00557 double var_membrane__i_NaK = var_sodium_potassium_pump__i_NaK;
00558 double var_non_specific_calcium_activated_current__F = var_membrane__F;
00559 double var_non_specific_calcium_activated_current__R = var_membrane__R;
00560 double var_non_specific_calcium_activated_current__T = var_membrane__T;
00561 double var_non_specific_calcium_activated_current__V = var_membrane__V;
00562 double var_non_specific_calcium_activated_current__P_ns_Ca = 0.0 * 1.75e-07;
00563 double var_non_specific_calcium_activated_current__Nao = var_ionic_concentrations__Nao;
00564 double var_non_specific_calcium_activated_current__gamma_Nai = var_L_type_Ca_channel__gamma_Nai;
00565 double var_non_specific_calcium_activated_current__gamma_Nao = var_L_type_Ca_channel__gamma_Nao;
00566 double var_non_specific_calcium_activated_current__Nai = var_ionic_concentrations__Nai;
00567 double var_non_specific_calcium_activated_current__I_ns_Na = (((var_non_specific_calcium_activated_current__P_ns_Ca * pow(1.0, 2.0) * var_non_specific_calcium_activated_current__V * pow(var_non_specific_calcium_activated_current__F, 2.0)) / (var_non_specific_calcium_activated_current__R * var_non_specific_calcium_activated_current__T)) * ((var_non_specific_calcium_activated_current__gamma_Nai * var_non_specific_calcium_activated_current__Nai * exp((1.0 * var_non_specific_calcium_activated_current__V * var_non_specific_calcium_activated_current__F) / (var_non_specific_calcium_activated_current__R * var_non_specific_calcium_activated_current__T))) - (var_non_specific_calcium_activated_current__gamma_Nao * var_non_specific_calcium_activated_current__Nao))) / (exp((1.0 * var_non_specific_calcium_activated_current__V * var_non_specific_calcium_activated_current__F) / (var_non_specific_calcium_activated_current__R * var_non_specific_calcium_activated_current__T)) - 1.0);
00568 const double var_non_specific_calcium_activated_current__K_m_ns_Ca = 0.0012;
00569 double var_non_specific_calcium_activated_current__Cai = var_calcium_dynamics__Cai;
00570 double var_non_specific_calcium_activated_current__i_ns_Na = (var_non_specific_calcium_activated_current__I_ns_Na * 1.0) / (1.0 + pow(var_non_specific_calcium_activated_current__K_m_ns_Ca / var_non_specific_calcium_activated_current__Cai, 3.0));
00571 double var_non_specific_calcium_activated_current__Ko = var_ionic_concentrations__Ko;
00572 double var_non_specific_calcium_activated_current__Ki = var_ionic_concentrations__Ki;
00573 double var_non_specific_calcium_activated_current__gamma_Ko = var_L_type_Ca_channel__gamma_Ko;
00574 double var_non_specific_calcium_activated_current__gamma_Ki = var_L_type_Ca_channel__gamma_Ki;
00575 double var_non_specific_calcium_activated_current__I_ns_K = (((var_non_specific_calcium_activated_current__P_ns_Ca * pow(1.0, 2.0) * var_non_specific_calcium_activated_current__V * pow(var_non_specific_calcium_activated_current__F, 2.0)) / (var_non_specific_calcium_activated_current__R * var_non_specific_calcium_activated_current__T)) * ((var_non_specific_calcium_activated_current__gamma_Ki * var_non_specific_calcium_activated_current__Ki * exp((1.0 * var_non_specific_calcium_activated_current__V * var_non_specific_calcium_activated_current__F) / (var_non_specific_calcium_activated_current__R * var_non_specific_calcium_activated_current__T))) - (var_non_specific_calcium_activated_current__gamma_Ko * var_non_specific_calcium_activated_current__Ko))) / (exp((1.0 * var_non_specific_calcium_activated_current__V * var_non_specific_calcium_activated_current__F) / (var_non_specific_calcium_activated_current__R * var_non_specific_calcium_activated_current__T)) - 1.0);
00576 double var_non_specific_calcium_activated_current__i_ns_K = (var_non_specific_calcium_activated_current__I_ns_K * 1.0) / (1.0 + pow(var_non_specific_calcium_activated_current__K_m_ns_Ca / var_non_specific_calcium_activated_current__Cai, 3.0));
00577 double var_non_specific_calcium_activated_current__i_ns_Ca = var_non_specific_calcium_activated_current__i_ns_Na + var_non_specific_calcium_activated_current__i_ns_K;
00578 double var_membrane__i_ns_Ca = var_non_specific_calcium_activated_current__i_ns_Ca;
00579 double var_membrane__dVdt = ((-1.0) / var_membrane__Cm) * (var_membrane__i_Na + var_membrane__i_Ca_L + var_membrane__i_Ca_T + var_membrane__i_Kr + var_membrane__i_Ks + var_membrane__i_K_Na + var_membrane__i_K_ATP + var_membrane__i_to + var_membrane__i_K1 + var_membrane__i_Kp + var_membrane__i_NaCa + var_membrane__i_p_Ca + var_membrane__i_Na_b + var_membrane__i_Ca_b + var_membrane__i_NaK + var_membrane__i_ns_Ca + var_membrane__I_st);
00580 double var_fast_sodium_current_m_gate__V = var_fast_sodium_current__V;
00581 double var_fast_sodium_current_m_gate__E0_m = var_fast_sodium_current_m_gate__V + 47.13;
00582 const double var_fast_sodium_current_m_gate__delta_m = 1e-05;
00583 double var_fast_sodium_current_m_gate__alpha_m = (fabs(var_fast_sodium_current_m_gate__E0_m) >= var_fast_sodium_current_m_gate__delta_m) ? ((320.0 * var_fast_sodium_current_m_gate__E0_m) / (1.0 - exp((-0.1) * var_fast_sodium_current_m_gate__E0_m))) : 3200.0;
00584 double var_fast_sodium_current_m_gate__beta_m = 80.0 * exp((-var_fast_sodium_current_m_gate__V) / 11.0);
00585 double var_fast_sodium_current_h_gate__V = var_fast_sodium_current__V;
00586 double var_fast_sodium_current_h_gate__alpha_h = (var_fast_sodium_current_h_gate__V < (-40.0)) ? (135.0 * exp((80.0 + var_fast_sodium_current_h_gate__V) / (-6.8))) : 0.0;
00587 double var_fast_sodium_current_h_gate__beta_h = (var_fast_sodium_current_h_gate__V < (-40.0)) ? ((3560.0 * exp(0.079 * var_fast_sodium_current_h_gate__V)) + (310000000.0 * exp(0.35 * var_fast_sodium_current_h_gate__V))) : (1000.0 / (0.13 * (1.0 + exp((var_fast_sodium_current_h_gate__V + 10.66) / (-11.1)))));
00588 double var_fast_sodium_current_j_gate__V = var_fast_sodium_current__V;
00589 double var_fast_sodium_current_j_gate__alpha_j = (var_fast_sodium_current_j_gate__V < (-40.0)) ? ((1000.0 * (-((127140.0 * exp(0.2444 * var_fast_sodium_current_j_gate__V)) + (3.474e-05 * exp((-0.04391) * var_fast_sodium_current_j_gate__V)))) * (var_fast_sodium_current_j_gate__V + 37.78)) / (1.0 + exp(0.311 * (var_fast_sodium_current_j_gate__V + 79.23)))) : 0.0;
00590 double var_fast_sodium_current_j_gate__beta_j = (var_fast_sodium_current_j_gate__V < (-40.0)) ? ((121.2 * exp((-0.01052) * var_fast_sodium_current_j_gate__V)) / (1.0 + exp((-0.1378) * (var_fast_sodium_current_j_gate__V + 40.14)))) : ((300.0 * exp((-2.535e-07) * var_fast_sodium_current_j_gate__V)) / (1.0 + exp((-0.1) * (var_fast_sodium_current_j_gate__V + 32.0))));
00591 double var_L_type_Ca_channel_d_gate__V = var_L_type_Ca_channel__V;
00592 double var_L_type_Ca_channel_d_gate__E0_d = var_L_type_Ca_channel_d_gate__V + 10.0;
00593 double var_L_type_Ca_channel_d_gate__d_infinity = 1.0 / (1.0 + exp((-var_L_type_Ca_channel_d_gate__E0_d) / 6.24));
00594 double var_L_type_Ca_channel_d_gate__tau_d = (fabs(var_L_type_Ca_channel_d_gate__E0_d) < 1e-05) ? (0.001 / (0.035 * 6.24)) : ((0.001 * var_L_type_Ca_channel_d_gate__d_infinity * (1.0 - exp((-var_L_type_Ca_channel_d_gate__E0_d) / 6.24))) / (0.035 * var_L_type_Ca_channel_d_gate__E0_d));
00595 double var_L_type_Ca_channel_d_gate__alpha_d = var_L_type_Ca_channel_d_gate__d_infinity / var_L_type_Ca_channel_d_gate__tau_d;
00596 double var_L_type_Ca_channel_d_gate__beta_d = (1.0 - var_L_type_Ca_channel_d_gate__d_infinity) / var_L_type_Ca_channel_d_gate__tau_d;
00597 double var_L_type_Ca_channel_f_gate__V = var_L_type_Ca_channel__V;
00598 double var_L_type_Ca_channel_f_gate__f_infinity = (1.0 / (1.0 + exp((var_L_type_Ca_channel_f_gate__V + 32.0) / 8.0))) + (0.6 / (1.0 + exp((50.0 - var_L_type_Ca_channel_f_gate__V) / 20.0)));
00599 double var_L_type_Ca_channel_f_gate__tau_f = 0.001 / ((0.0197 * exp(-pow(0.0337 * (var_L_type_Ca_channel_f_gate__V + 10.0), 2.0))) + 0.02);
00600 double var_L_type_Ca_channel_f_gate__alpha_f = var_L_type_Ca_channel_f_gate__f_infinity / var_L_type_Ca_channel_f_gate__tau_f;
00601 double var_L_type_Ca_channel_f_gate__beta_f = (1.0 - var_L_type_Ca_channel_f_gate__f_infinity) / var_L_type_Ca_channel_f_gate__tau_f;
00602 double var_T_type_Ca_channel_b_gate__V = var_T_type_Ca_channel__V;
00603 double var_T_type_Ca_channel_b_gate__b_inf = 1.0 / (1.0 + exp((-(var_T_type_Ca_channel_b_gate__V + 14.0)) / 10.8));
00604 double var_T_type_Ca_channel_b_gate__tau_b = 0.0037 + (0.0061 / (1.0 + exp((var_T_type_Ca_channel_b_gate__V + 25.0) / 4.5)));
00605 double var_T_type_Ca_channel_g_gate__V = var_T_type_Ca_channel__V;
00606 double var_T_type_Ca_channel_g_gate__g_inf = 1.0 / (1.0 + exp((var_T_type_Ca_channel_g_gate__V + 60.0) / 5.6));
00607 double var_T_type_Ca_channel_g_gate__tau_g = (var_T_type_Ca_channel_g_gate__V <= 0.0) ? (((-0.000875) * var_T_type_Ca_channel_g_gate__V) + 0.012) : 0.012;
00608 double var_rapid_delayed_rectifier_potassium_current_xr_gate__V = var_rapid_delayed_rectifier_potassium_current__V;
00609 double var_rapid_delayed_rectifier_potassium_current_xr_gate__xr_infinity = 1.0 / (1.0 + exp((-(var_rapid_delayed_rectifier_potassium_current_xr_gate__V + 21.5)) / 7.5));
00610 double var_rapid_delayed_rectifier_potassium_current_xr_gate__tau_xr = 0.001 / (((0.00138 * (var_rapid_delayed_rectifier_potassium_current_xr_gate__V + 14.2)) / (1.0 - exp((-0.123) * (var_rapid_delayed_rectifier_potassium_current_xr_gate__V + 14.2)))) + ((0.00061 * (var_rapid_delayed_rectifier_potassium_current_xr_gate__V + 38.9)) / (exp(0.145 * (var_rapid_delayed_rectifier_potassium_current_xr_gate__V + 38.9)) - 1.0)));
00611 double var_slow_delayed_rectifier_potassium_current_xs1_gate__V = var_slow_delayed_rectifier_potassium_current__V;
00612 double var_slow_delayed_rectifier_potassium_current_xs1_gate__xs1_infinity = 1.0 / (1.0 + exp((-(var_slow_delayed_rectifier_potassium_current_xs1_gate__V - 1.5)) / 16.7));
00613 double var_slow_delayed_rectifier_potassium_current_xs1_gate__tau_xs1 = 0.001 / (((7.19e-05 * (var_slow_delayed_rectifier_potassium_current_xs1_gate__V + 30.0)) / (1.0 - exp((-0.148) * (var_slow_delayed_rectifier_potassium_current_xs1_gate__V + 30.0)))) + ((0.000131 * (var_slow_delayed_rectifier_potassium_current_xs1_gate__V + 30.0)) / (exp(0.0687 * (var_slow_delayed_rectifier_potassium_current_xs1_gate__V + 30.0)) - 1.0)));
00614 double var_slow_delayed_rectifier_potassium_current_xs2_gate__V = var_slow_delayed_rectifier_potassium_current__V;
00615 double var_slow_delayed_rectifier_potassium_current_xs2_gate__xs2_infinity = 1.0 / (1.0 + exp((-(var_slow_delayed_rectifier_potassium_current_xs2_gate__V - 1.5)) / 16.7));
00616 double var_slow_delayed_rectifier_potassium_current_xs2_gate__tau_xs2 = (4.0 * 0.001) / (((7.19e-05 * (var_slow_delayed_rectifier_potassium_current_xs2_gate__V + 30.0)) / (1.0 - exp((-0.148) * (var_slow_delayed_rectifier_potassium_current_xs2_gate__V + 30.0)))) + ((0.000131 * (var_slow_delayed_rectifier_potassium_current_xs2_gate__V + 30.0)) / (exp(0.0687 * (var_slow_delayed_rectifier_potassium_current_xs2_gate__V + 30.0)) - 1.0)));
00617 double var_transient_outward_current_zdv_gate__V = var_transient_outward_current__V;
00618 double var_transient_outward_current_zdv_gate__alpha_zdv = (10000.0 * exp((var_transient_outward_current_zdv_gate__V - 40.0) / 25.0)) / (1.0 + exp((var_transient_outward_current_zdv_gate__V - 40.0) / 25.0));
00619 double var_transient_outward_current_zdv_gate__beta_zdv = (10000.0 * exp((-(var_transient_outward_current_zdv_gate__V + 90.0)) / 25.0)) / (1.0 + exp((-(var_transient_outward_current_zdv_gate__V + 90.0)) / 25.0));
00620 double var_transient_outward_current_zdv_gate__tau_zdv = 1.0 / (var_transient_outward_current_zdv_gate__alpha_zdv + var_transient_outward_current_zdv_gate__beta_zdv);
00621 double var_transient_outward_current_zdv_gate__zdv_ss = var_transient_outward_current_zdv_gate__alpha_zdv / (var_transient_outward_current_zdv_gate__alpha_zdv + var_transient_outward_current_zdv_gate__beta_zdv);
00622 double var_transient_outward_current_ydv_gate__V = var_transient_outward_current__V;
00623 double var_transient_outward_current_ydv_gate__alpha_ydv = 15.0 / (1.0 + exp((var_transient_outward_current_ydv_gate__V + 60.0) / 5.0));
00624 double var_transient_outward_current_ydv_gate__beta_ydv = (100.0 * exp((var_transient_outward_current_ydv_gate__V + 25.0) / 5.0)) / (1.0 + exp((var_transient_outward_current_ydv_gate__V + 25.0) / 5.0));
00625 double var_transient_outward_current_ydv_gate__tau_ydv = 1.0 / (var_transient_outward_current_ydv_gate__alpha_ydv + var_transient_outward_current_ydv_gate__beta_ydv);
00626 double var_transient_outward_current_ydv_gate__ydv_ss = var_transient_outward_current_ydv_gate__alpha_ydv / (var_transient_outward_current_ydv_gate__alpha_ydv + var_transient_outward_current_ydv_gate__beta_ydv);
00627 const double var_calcium_dynamics__delta_Ca_ith = 0.00018;
00628 const double var_calcium_dynamics__K_mrel = 0.0008;
00629 const double var_calcium_dynamics__G_rel_max = 60000.0;
00630 const double var_calcium_dynamics__G_rel_overload = 4000.0;
00631 double var_calcium_dynamics__G_rel = (var_calcium_dynamics__Cainfluxtrack > var_calcium_dynamics__delta_Ca_ith) ? (((var_calcium_dynamics__G_rel_max * (var_calcium_dynamics__Cainfluxtrack - var_calcium_dynamics__delta_Ca_ith)) / ((var_calcium_dynamics__K_mrel + var_calcium_dynamics__Cainfluxtrack) - var_calcium_dynamics__delta_Ca_ith)) * (1.0 - var_calcium_dynamics__APtrack2) * var_calcium_dynamics__APtrack2) : ((var_calcium_dynamics__Cainfluxtrack <= var_calcium_dynamics__delta_Ca_ith) && (var_calcium_dynamics__OVRLDtrack2 > 0.0)) ? (var_calcium_dynamics__G_rel_overload * (1.0 - var_calcium_dynamics__OVRLDtrack2) * var_calcium_dynamics__OVRLDtrack2) : 0.0;
00632 double var_calcium_dynamics__i_rel = var_calcium_dynamics__G_rel * (var_calcium_dynamics__Ca_JSR - var_calcium_dynamics__Cai);
00633 const double var_calcium_dynamics__K_mup = 0.00092;
00634 const double var_calcium_dynamics__I_up = 8.75;
00635 double var_calcium_dynamics__i_up = (var_calcium_dynamics__I_up * var_calcium_dynamics__Cai) / (var_calcium_dynamics__Cai + var_calcium_dynamics__K_mup);
00636 const double var_calcium_dynamics__Ca_NSR_max = 15.0;
00637 double var_calcium_dynamics__K_leak = var_calcium_dynamics__I_up / var_calcium_dynamics__Ca_NSR_max;
00638 double var_calcium_dynamics__i_leak = var_calcium_dynamics__K_leak * var_calcium_dynamics__Ca_NSR;
00639 const double var_calcium_dynamics__tau_tr = 0.18;
00640 double var_calcium_dynamics__i_tr = (var_calcium_dynamics__Ca_NSR - var_calcium_dynamics__Ca_JSR) / var_calcium_dynamics__tau_tr;
00641 const double var_calcium_dynamics__CSQN_max = 10.0;
00642 const double var_calcium_dynamics__K_mCSQN = 0.8;
00643 double var_calcium_dynamics__F = var_membrane__F;
00644 const double var_ionic_concentrations__preplength = 0.001;
00645 const double var_ionic_concentrations__radius = 0.00011;
00646 double var_ionic_concentrations__volume = M_PI * var_ionic_concentrations__preplength * pow(var_ionic_concentrations__radius, 2.0);
00647 double var_ionic_concentrations__V_myo = 0.68 * var_ionic_concentrations__volume;
00648 double var_calcium_dynamics__V_myo = var_ionic_concentrations__V_myo;
00649 const double var_ionic_concentrations__A_cap = 1.434e-07;
00650 double var_calcium_dynamics__A_cap = var_ionic_concentrations__A_cap;
00651 double var_calcium_dynamics__V_JSR = (0.0048 / 0.68) * var_calcium_dynamics__V_myo;
00652 double var_calcium_dynamics__V_NSR = (0.0552 / 0.68) * var_calcium_dynamics__V_myo;
00653 double var_calcium_dynamics__i_NaCa = var_Na_Ca_exchanger__i_NaCa;
00654 double var_calcium_dynamics__i_CaCa = var_L_type_Ca_channel__i_CaCa;
00655 double var_calcium_dynamics__i_p_Ca = var_sarcolemmal_calcium_pump__i_p_Ca;
00656 double var_calcium_dynamics__i_Ca_b = var_calcium_background_current__i_Ca_b;
00657 double var_calcium_dynamics__i_Ca_T = var_T_type_Ca_channel__i_Ca_T;
00658 const double var_calcium_dynamics__K_mTn = 0.0005;
00659 const double var_calcium_dynamics__K_mCMDN = 0.00238;
00660 const double var_calcium_dynamics__Tn_max = 0.07;
00661 const double var_calcium_dynamics__CMDN_max = 0.05;
00662 double var_calcium_dynamics__dVdt = var_membrane__dVdt;
00663 const double var_calcium_dynamics__CSQNthresh = 0.7;
00664 const double var_calcium_dynamics__Logicthresh = 0.98;
00665 double var_ionic_concentrations__F = var_membrane__F;
00666 double var_ionic_concentrations__i_Na = var_fast_sodium_current__i_Na;
00667 double var_ionic_concentrations__i_CaNa = var_L_type_Ca_channel__i_CaNa;
00668 double var_ionic_concentrations__i_Na_b = var_sodium_background_current__i_Na_b;
00669 double var_ionic_concentrations__i_ns_Na = var_non_specific_calcium_activated_current__i_ns_Na;
00670 double var_ionic_concentrations__i_NaCa = var_Na_Ca_exchanger__i_NaCa;
00671 double var_ionic_concentrations__i_NaK = var_sodium_potassium_pump__i_NaK;
00672 double var_ionic_concentrations__i_CaK = var_L_type_Ca_channel__i_CaK;
00673 double var_ionic_concentrations__i_Kr = var_rapid_delayed_rectifier_potassium_current__i_Kr;
00674 double var_ionic_concentrations__i_Ks = var_slow_delayed_rectifier_potassium_current__i_Ks;
00675 double var_ionic_concentrations__i_K1 = var_time_independent_potassium_current__i_K1;
00676 double var_ionic_concentrations__i_Kp = var_plateau_potassium_current__i_Kp;
00677 double var_ionic_concentrations__i_K_Na = var_sodium_activated_potassium_current__i_K_Na;
00678 double var_ionic_concentrations__i_K_ATP = var_ATP_sensitive_potassium_current__i_K_ATP;
00679 double var_ionic_concentrations__i_ns_K = var_non_specific_calcium_activated_current__i_ns_K;
00680 double var_ionic_concentrations__i_to = var_transient_outward_current__i_to;
00681 double d_dt_membrane__V;
00682 if (mSetVoltageDerivativeToZero)
00683 {
00684 d_dt_membrane__V = 0.0;
00685 }
00686 else
00687 {
00688 d_dt_membrane__V = ((-1.0) / var_membrane__Cm) * (var_membrane__i_Na + var_membrane__i_Ca_L + var_membrane__i_Ca_T + var_membrane__i_Kr + var_membrane__i_Ks + var_membrane__i_K_Na + var_membrane__i_K_ATP + var_membrane__i_to + var_membrane__i_K1 + var_membrane__i_Kp + var_membrane__i_NaCa + var_membrane__i_p_Ca + var_membrane__i_Na_b + var_membrane__i_Ca_b + var_membrane__i_NaK + var_membrane__i_ns_Ca + var_membrane__I_st);
00689 }
00690 double d_dt_fast_sodium_current_m_gate__m = (var_fast_sodium_current_m_gate__alpha_m * (1.0 - var_fast_sodium_current_m_gate__m)) - (var_fast_sodium_current_m_gate__beta_m * var_fast_sodium_current_m_gate__m);
00691 double d_dt_fast_sodium_current_h_gate__h = (var_fast_sodium_current_h_gate__alpha_h * (1.0 - var_fast_sodium_current_h_gate__h)) - (var_fast_sodium_current_h_gate__beta_h * var_fast_sodium_current_h_gate__h);
00692 double d_dt_fast_sodium_current_j_gate__j = (var_fast_sodium_current_j_gate__alpha_j * (1.0 - var_fast_sodium_current_j_gate__j)) - (var_fast_sodium_current_j_gate__beta_j * var_fast_sodium_current_j_gate__j);
00693 double d_dt_L_type_Ca_channel_d_gate__d = (var_L_type_Ca_channel_d_gate__alpha_d * (1.0 - var_L_type_Ca_channel_d_gate__d)) - (var_L_type_Ca_channel_d_gate__beta_d * var_L_type_Ca_channel_d_gate__d);
00694 double d_dt_L_type_Ca_channel_f_gate__f = (var_L_type_Ca_channel_f_gate__alpha_f * (1.0 - var_L_type_Ca_channel_f_gate__f)) - (var_L_type_Ca_channel_f_gate__beta_f * var_L_type_Ca_channel_f_gate__f);
00695 double d_dt_T_type_Ca_channel_b_gate__b = (var_T_type_Ca_channel_b_gate__b_inf - var_T_type_Ca_channel_b_gate__b) / var_T_type_Ca_channel_b_gate__tau_b;
00696 double d_dt_T_type_Ca_channel_g_gate__g = (var_T_type_Ca_channel_g_gate__g_inf - var_T_type_Ca_channel_g_gate__g) / var_T_type_Ca_channel_g_gate__tau_g;
00697 double d_dt_rapid_delayed_rectifier_potassium_current_xr_gate__xr = (var_rapid_delayed_rectifier_potassium_current_xr_gate__xr_infinity - var_rapid_delayed_rectifier_potassium_current_xr_gate__xr) / var_rapid_delayed_rectifier_potassium_current_xr_gate__tau_xr;
00698 double d_dt_slow_delayed_rectifier_potassium_current_xs1_gate__xs1 = (var_slow_delayed_rectifier_potassium_current_xs1_gate__xs1_infinity - var_slow_delayed_rectifier_potassium_current_xs1_gate__xs1) / var_slow_delayed_rectifier_potassium_current_xs1_gate__tau_xs1;
00699 double d_dt_slow_delayed_rectifier_potassium_current_xs2_gate__xs2 = (var_slow_delayed_rectifier_potassium_current_xs2_gate__xs2_infinity - var_slow_delayed_rectifier_potassium_current_xs2_gate__xs2) / var_slow_delayed_rectifier_potassium_current_xs2_gate__tau_xs2;
00700 double d_dt_transient_outward_current_zdv_gate__zdv = (var_transient_outward_current_zdv_gate__zdv_ss - var_transient_outward_current_zdv_gate__zdv) / var_transient_outward_current_zdv_gate__tau_zdv;
00701 double d_dt_transient_outward_current_ydv_gate__ydv = (var_transient_outward_current_ydv_gate__ydv_ss - var_transient_outward_current_ydv_gate__ydv) / var_transient_outward_current_ydv_gate__tau_ydv;
00702 double d_dt_calcium_dynamics__APtrack = (var_calcium_dynamics__dVdt > 150000.0) ? ((100000.0 * (1.0 - var_calcium_dynamics__APtrack)) - (500.0 * var_calcium_dynamics__APtrack)) : ((-500.0) * var_calcium_dynamics__APtrack);
00703 double d_dt_calcium_dynamics__APtrack2 = ((var_calcium_dynamics__APtrack < 0.2) && (var_calcium_dynamics__APtrack > 0.18)) ? ((100000.0 * (1.0 - var_calcium_dynamics__APtrack2)) - (500.0 * var_calcium_dynamics__APtrack2)) : ((-500.0) * var_calcium_dynamics__APtrack2);
00704 double d_dt_calcium_dynamics__APtrack3 = ((var_calcium_dynamics__APtrack < 0.2) && (var_calcium_dynamics__APtrack > 0.18)) ? ((100000.0 * (1.0 - var_calcium_dynamics__APtrack3)) - (500.0 * var_calcium_dynamics__APtrack3)) : ((-10.0) * var_calcium_dynamics__APtrack3);
00705 double d_dt_calcium_dynamics__Cainfluxtrack = (var_calcium_dynamics__APtrack > 0.2) ? (((-var_calcium_dynamics__A_cap) * (((var_calcium_dynamics__i_CaCa + var_calcium_dynamics__i_Ca_T) - var_calcium_dynamics__i_NaCa) + var_calcium_dynamics__i_p_Ca + var_calcium_dynamics__i_Ca_b)) / (2.0 * var_calcium_dynamics__V_myo * var_calcium_dynamics__F)) : ((var_calcium_dynamics__APtrack2 > 0.01) && (var_calcium_dynamics__APtrack <= 0.2)) ? 0.0 : ((-500.0) * var_calcium_dynamics__Cainfluxtrack);
00706 double d_dt_calcium_dynamics__OVRLDtrack = (((1.0 / (1.0 + (var_calcium_dynamics__K_mCSQN / var_calcium_dynamics__Ca_JSR))) > var_calcium_dynamics__CSQNthresh) && (var_calcium_dynamics__OVRLDtrack3 < 0.37) && (var_calcium_dynamics__APtrack3 < 0.37)) ? (50000.0 * (1.0 - var_calcium_dynamics__OVRLDtrack)) : ((-500.0) * var_calcium_dynamics__OVRLDtrack);
00707 double d_dt_calcium_dynamics__OVRLDtrack2 = ((var_calcium_dynamics__OVRLDtrack > var_calcium_dynamics__Logicthresh) && (var_calcium_dynamics__OVRLDtrack2 < var_calcium_dynamics__Logicthresh)) ? (50000.0 * (1.0 - var_calcium_dynamics__OVRLDtrack2)) : ((-500.0) * var_calcium_dynamics__OVRLDtrack2);
00708 double d_dt_calcium_dynamics__OVRLDtrack3 = ((var_calcium_dynamics__OVRLDtrack > var_calcium_dynamics__Logicthresh) && (var_calcium_dynamics__OVRLDtrack3 < var_calcium_dynamics__Logicthresh)) ? (50000.0 * (1.0 - var_calcium_dynamics__OVRLDtrack3)) : ((-10.0) * var_calcium_dynamics__OVRLDtrack3);
00709 double d_dt_calcium_dynamics__Ca_JSR = (1.0 / (1.0 + ((var_calcium_dynamics__CSQN_max * var_calcium_dynamics__K_mCSQN) / pow(var_calcium_dynamics__K_mCSQN + var_calcium_dynamics__Ca_JSR, 2.0)))) * (var_calcium_dynamics__i_tr - var_calcium_dynamics__i_rel);
00710 double d_dt_calcium_dynamics__Ca_NSR = ((((-var_calcium_dynamics__i_tr) * var_calcium_dynamics__V_JSR) / var_calcium_dynamics__V_NSR) - var_calcium_dynamics__i_leak) + var_calcium_dynamics__i_up;
00711 double d_dt_calcium_dynamics__Cai = (1.0 / (1.0 + ((var_calcium_dynamics__CMDN_max * var_calcium_dynamics__K_mCMDN) / pow(var_calcium_dynamics__K_mCMDN + var_calcium_dynamics__Cai, 2.0)) + ((var_calcium_dynamics__Tn_max * var_calcium_dynamics__K_mTn) / pow(var_calcium_dynamics__K_mTn + var_calcium_dynamics__Cai, 2.0)))) * ((((-var_calcium_dynamics__A_cap) * (((var_calcium_dynamics__i_CaCa + var_calcium_dynamics__i_Ca_T) - (2.0 * var_calcium_dynamics__i_NaCa)) + var_calcium_dynamics__i_p_Ca + var_calcium_dynamics__i_Ca_b)) / (2.0 * var_calcium_dynamics__V_myo * var_calcium_dynamics__F)) + ((var_calcium_dynamics__i_rel * var_calcium_dynamics__V_JSR) / var_calcium_dynamics__V_myo) + (((var_calcium_dynamics__i_leak - var_calcium_dynamics__i_up) * var_calcium_dynamics__V_NSR) / var_calcium_dynamics__V_myo));
00712 double d_dt_ionic_concentrations__Nai = ((-(var_ionic_concentrations__i_Na + var_ionic_concentrations__i_CaNa + var_ionic_concentrations__i_Na_b + var_ionic_concentrations__i_ns_Na + (var_ionic_concentrations__i_NaCa * 3.0) + (var_ionic_concentrations__i_NaK * 3.0))) * var_ionic_concentrations__A_cap) / (var_ionic_concentrations__V_myo * var_ionic_concentrations__F);
00713 double d_dt_ionic_concentrations__Ki = ((-(var_ionic_concentrations__i_CaK + var_ionic_concentrations__i_Kr + var_ionic_concentrations__i_Ks + var_ionic_concentrations__i_K1 + var_ionic_concentrations__i_Kp + var_ionic_concentrations__i_K_Na + var_ionic_concentrations__i_K_ATP + var_ionic_concentrations__i_to + var_ionic_concentrations__i_ns_K + ((-var_ionic_concentrations__i_NaK) * 2.0))) * var_ionic_concentrations__A_cap) / (var_ionic_concentrations__V_myo * var_ionic_concentrations__F);
00714
00715 rDY[0] = d_dt_membrane__V*1e-3;
00716 rDY[1] = d_dt_fast_sodium_current_m_gate__m*1e-3;
00717 rDY[2] = d_dt_fast_sodium_current_h_gate__h*1e-3;
00718 rDY[3] = d_dt_fast_sodium_current_j_gate__j*1e-3;
00719 rDY[4] = d_dt_L_type_Ca_channel_d_gate__d*1e-3;
00720 rDY[5] = d_dt_L_type_Ca_channel_f_gate__f*1e-3;
00721 rDY[6] = d_dt_T_type_Ca_channel_b_gate__b*1e-3;
00722 rDY[7] = d_dt_T_type_Ca_channel_g_gate__g*1e-3;
00723 rDY[8] = d_dt_rapid_delayed_rectifier_potassium_current_xr_gate__xr*1e-3;
00724 rDY[9] = d_dt_slow_delayed_rectifier_potassium_current_xs1_gate__xs1*1e-3;
00725 rDY[10] = d_dt_slow_delayed_rectifier_potassium_current_xs2_gate__xs2*1e-3;
00726 rDY[11] = d_dt_transient_outward_current_zdv_gate__zdv*1e-3;
00727 rDY[12] = d_dt_transient_outward_current_ydv_gate__ydv*1e-3;
00728 rDY[13] = d_dt_calcium_dynamics__Cai*1e-3;
00729 rDY[14] = d_dt_calcium_dynamics__Ca_JSR*1e-3;
00730 rDY[15] = d_dt_calcium_dynamics__Ca_NSR*1e-3;
00731 rDY[16] = d_dt_calcium_dynamics__APtrack*1e-3;
00732 rDY[17] = d_dt_calcium_dynamics__APtrack2*1e-3;
00733 rDY[18] = d_dt_calcium_dynamics__APtrack3*1e-3;
00734 rDY[19] = d_dt_calcium_dynamics__Cainfluxtrack*1e-3;
00735 rDY[20] = d_dt_calcium_dynamics__OVRLDtrack*1e-3;
00736 rDY[21] = d_dt_calcium_dynamics__OVRLDtrack2*1e-3;
00737 rDY[22] = d_dt_calcium_dynamics__OVRLDtrack3*1e-3;
00738 rDY[23] = d_dt_ionic_concentrations__Nai*1e-3;
00739 rDY[24] = d_dt_ionic_concentrations__Ki*1e-3;
00740 }
00741
00742 };
00743
00744
00745
00746 template<>
00747 void OdeSystemInformation<FaberRudy2000Version3>::Initialise(void)
00748 {
00749
00750 this->mVariableNames.push_back("V");
00751 this->mVariableUnits.push_back("millivolt");
00752 this->mInitialConditions.push_back(-90);
00753
00754 this->mVariableNames.push_back("m");
00755 this->mVariableUnits.push_back("dimensionless");
00756 this->mInitialConditions.push_back(0.0008);
00757
00758 this->mVariableNames.push_back("h");
00759 this->mVariableUnits.push_back("dimensionless");
00760 this->mInitialConditions.push_back(0.993771);
00761
00762 this->mVariableNames.push_back("j");
00763 this->mVariableUnits.push_back("dimensionless");
00764 this->mInitialConditions.push_back(0.995727);
00765
00766 this->mVariableNames.push_back("d");
00767 this->mVariableUnits.push_back("dimensionless");
00768 this->mInitialConditions.push_back(3.210618e-6);
00769
00770 this->mVariableNames.push_back("f");
00771 this->mVariableUnits.push_back("dimensionless");
00772 this->mInitialConditions.push_back(0.999837);
00773
00774 this->mVariableNames.push_back("b");
00775 this->mVariableUnits.push_back("dimensionless");
00776 this->mInitialConditions.push_back(0.000970231);
00777
00778 this->mVariableNames.push_back("g");
00779 this->mVariableUnits.push_back("dimensionless");
00780 this->mInitialConditions.push_back(0.994305);
00781
00782 this->mVariableNames.push_back("xr");
00783 this->mVariableUnits.push_back("dimensionless");
00784 this->mInitialConditions.push_back(0.000124042);
00785
00786 this->mVariableNames.push_back("xs1");
00787 this->mVariableUnits.push_back("dimensionless");
00788 this->mInitialConditions.push_back(0.00445683);
00789
00790 this->mVariableNames.push_back("xs2");
00791 this->mVariableUnits.push_back("dimensionless");
00792 this->mInitialConditions.push_back(0.00445683);
00793
00794 this->mVariableNames.push_back("zdv");
00795 this->mVariableUnits.push_back("dimensionless");
00796 this->mInitialConditions.push_back(0.5);
00797
00798 this->mVariableNames.push_back("ydv");
00799 this->mVariableUnits.push_back("dimensionless");
00800 this->mInitialConditions.push_back(0.5);
00801
00802 this->mVariableNames.push_back("CaI");
00803 this->mVariableUnits.push_back("millimolar");
00804 this->mInitialConditions.push_back(6e-5);
00805
00806 this->mVariableNames.push_back("Ca_JSR");
00807 this->mVariableUnits.push_back("millimolar");
00808 this->mInitialConditions.push_back(1.8);
00809
00810 this->mVariableNames.push_back("Ca_NSR");
00811 this->mVariableUnits.push_back("millimolar");
00812 this->mInitialConditions.push_back(1.8);
00813
00814 this->mVariableNames.push_back("APtrack");
00815 this->mVariableUnits.push_back("dimensionless");
00816 this->mInitialConditions.push_back(0);
00817
00818 this->mVariableNames.push_back("APtrack2");
00819 this->mVariableUnits.push_back("dimensionless");
00820 this->mInitialConditions.push_back(0);
00821
00822 this->mVariableNames.push_back("APtrack3");
00823 this->mVariableUnits.push_back("dimensionless");
00824 this->mInitialConditions.push_back(0);
00825
00826 this->mVariableNames.push_back("Cainfluxtrack");
00827 this->mVariableUnits.push_back("dimensionless");
00828 this->mInitialConditions.push_back(0);
00829
00830 this->mVariableNames.push_back("OVRLDtrack");
00831 this->mVariableUnits.push_back("dimensionless");
00832 this->mInitialConditions.push_back(0);
00833
00834 this->mVariableNames.push_back("OVRLDtrack2");
00835 this->mVariableUnits.push_back("dimensionless");
00836 this->mInitialConditions.push_back(0);
00837
00838 this->mVariableNames.push_back("OVRLDtrack3");
00839 this->mVariableUnits.push_back("dimensionless");
00840 this->mInitialConditions.push_back(0);
00841
00842 this->mVariableNames.push_back("Nai");
00843 this->mVariableUnits.push_back("millimolar");
00844 this->mInitialConditions.push_back(9);
00845
00846 this->mVariableNames.push_back("Ki");
00847 this->mVariableUnits.push_back("millimolar");
00848 this->mInitialConditions.push_back(141.2);
00849
00850 this->mInitialised = true;
00851 }
00852
00853
00854
00855 #endif