00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2009 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 #ifndef WNTCONCENTRATION_HPP_ 00029 #define WNTCONCENTRATION_HPP_ 00030 00031 #include <boost/serialization/access.hpp> 00032 #include <boost/serialization/base_object.hpp> 00033 00034 #include <iostream> 00035 00036 #include "MeshBasedTissue.hpp" 00037 00038 // Needs to be included last 00039 #include <boost/serialization/export.hpp> 00040 00047 typedef enum WntConcentrationType_ 00048 { 00049 NONE, 00050 LINEAR, 00051 RADIAL 00052 } WntConcentrationType; 00053 00054 00058 class WntConcentration 00059 { 00060 private: 00061 00063 static WntConcentration* mpInstance; 00064 00066 CancerParameters* mpCancerParams; 00067 00074 WntConcentrationType mWntType; 00075 00079 AbstractTissue<2>* mpTissue; 00080 00084 bool mTypeSet; 00085 00089 double mConstantWntValueForTesting; 00090 00095 bool mUseConstantWntValueForTesting; 00096 00098 friend class boost::serialization::access; 00105 template<class Archive> 00106 void serialize(Archive & archive, const unsigned int version) 00107 { 00108 mpCancerParams = CancerParameters::Instance(); 00109 archive & *mpCancerParams; 00110 archive & mpCancerParams; 00111 archive & mWntType; 00112 archive & mpTissue; 00113 archive & mTypeSet; 00114 archive & mConstantWntValueForTesting; 00115 archive & mUseConstantWntValueForTesting; 00116 } 00117 00118 protected: 00119 00123 WntConcentration(); 00124 00125 public: 00126 00133 static WntConcentration* Instance(); 00134 00138 virtual ~WntConcentration(); 00139 00144 static void Destroy(); 00145 00153 double GetWntLevel(double height); 00154 00163 double GetWntLevel(TissueCell* pCell); 00164 00171 c_vector<double,2> GetWntGradient(c_vector<double,2> location); 00172 00180 c_vector<double,2> GetWntGradient(TissueCell* pCell); 00181 00187 void SetTissue(AbstractTissue<2>& rTissue); 00188 00192 WntConcentrationType GetType(); 00193 00199 void SetType(WntConcentrationType type); 00200 00207 void SetConstantWntValueForTesting(double value); 00208 00219 bool IsWntSetUp(); 00220 00221 }; 00222 00223 BOOST_CLASS_EXPORT(WntConcentration); 00224 00225 #endif /*WNTCONCENTRATION_HPP_*/