00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2010 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 #include "RandomCellKiller.hpp" 00029 00030 00031 template<unsigned DIM> 00032 RandomCellKiller<DIM>::RandomCellKiller(AbstractTissue<DIM>* pTissue, double probabilityOfDeathInAnHour) 00033 : AbstractCellKiller<DIM>(pTissue), 00034 mProbabilityOfDeathInAnHour(probabilityOfDeathInAnHour) 00035 { 00036 if ((mProbabilityOfDeathInAnHour<0) || (mProbabilityOfDeathInAnHour>1)) 00037 { 00038 EXCEPTION("Probability of death must be between zero and one"); 00039 } 00040 } 00041 00042 template<unsigned DIM> 00043 double RandomCellKiller<DIM>::GetDeathProbabilityInAnHour() const 00044 { 00045 return mProbabilityOfDeathInAnHour; 00046 } 00047 00048 template<unsigned DIM> 00049 void RandomCellKiller<DIM>::TestAndLabelSingleCellForApoptosis(TissueCell& rCell) 00050 { 00051 // We assume a constant time step 00052 double death_prob_this_timestep = 1.0 - pow((1.0 - mProbabilityOfDeathInAnHour), SimulationTime::Instance()->GetTimeStep()); 00053 00054 if (!rCell.HasApoptosisBegun() && 00055 RandomNumberGenerator::Instance()->ranf() < death_prob_this_timestep) 00056 { 00057 rCell.StartApoptosis(); 00058 } 00059 } 00060 00061 template<unsigned DIM> 00062 void RandomCellKiller<DIM>::TestAndLabelCellsForApoptosisOrDeath() 00063 { 00064 for (typename AbstractTissue<DIM>::Iterator cell_iter = this->mpTissue->Begin(); 00065 cell_iter != this->mpTissue->End(); 00066 ++cell_iter) 00067 { 00068 TestAndLabelSingleCellForApoptosis(*cell_iter); 00069 } 00070 } 00071 00072 00074 // Explicit instantiation 00076 00077 template class RandomCellKiller<1>; 00078 template class RandomCellKiller<2>; 00079 template class RandomCellKiller<3>; 00080 00081 00082 // Serialization for Boost >= 1.36 00083 #include "SerializationExportWrapperForCpp.hpp" 00084 EXPORT_TEMPLATE_CLASS_SAME_DIMS(RandomCellKiller)