00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2011 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 #include "AbstractSimpleCellCycleModel.hpp" 00029 #include "PetscTools.hpp" 00030 00031 AbstractSimpleCellCycleModel::AbstractSimpleCellCycleModel() 00032 { 00033 } 00034 00035 AbstractSimpleCellCycleModel::~AbstractSimpleCellCycleModel() 00036 { 00037 } 00038 00039 void AbstractSimpleCellCycleModel::Initialise() 00040 { 00041 SetG1Duration(); 00042 } 00043 00044 void AbstractSimpleCellCycleModel::InitialiseDaughterCell() 00045 { 00046 AbstractCellCycleModel::InitialiseDaughterCell(); 00047 SetG1Duration(); 00048 } 00049 00050 void AbstractSimpleCellCycleModel::SetG1Duration() 00051 { 00052 assert(mpCell != NULL); 00053 00054 switch (mCellProliferativeType) 00055 { 00056 case STEM: 00057 mG1Duration = GetStemCellG1Duration(); 00058 break; 00059 case TRANSIT: 00060 mG1Duration = GetTransitCellG1Duration(); 00061 break; 00062 case DIFFERENTIATED: 00063 mG1Duration = DBL_MAX; 00064 break; 00065 default: 00066 NEVER_REACHED; 00067 } 00068 } 00069 00070 void AbstractSimpleCellCycleModel::ResetForDivision() 00071 { 00072 AbstractCellCycleModel::ResetForDivision(); 00073 mBirthTime = SimulationTime::Instance()->GetTime(); 00074 SetG1Duration(); 00075 } 00076 00077 void AbstractSimpleCellCycleModel::UpdateCellCyclePhase() 00078 { 00079 double time_since_birth = GetAge(); 00080 assert(time_since_birth >= 0); 00081 00082 if (mCellProliferativeType == DIFFERENTIATED) 00083 { 00084 mCurrentCellCyclePhase = G_ZERO_PHASE; 00085 } 00086 else if (time_since_birth < GetMDuration()) 00087 { 00088 mCurrentCellCyclePhase = M_PHASE; 00089 } 00090 else if (time_since_birth < GetMDuration() + mG1Duration) 00091 { 00092 mCurrentCellCyclePhase = G_ONE_PHASE; 00093 } 00094 else if (time_since_birth < GetMDuration() + mG1Duration + GetSDuration()) 00095 { 00096 mCurrentCellCyclePhase = S_PHASE; 00097 } 00098 else if (time_since_birth < GetMDuration() + mG1Duration + GetSDuration() + GetG2Duration()) 00099 { 00100 mCurrentCellCyclePhase = G_TWO_PHASE; 00101 } 00102 } 00103 00104 void AbstractSimpleCellCycleModel::OutputCellCycleModelParameters(out_stream& rParamsFile) 00105 { 00106 // No new parameters to output 00107 00108 // Call method on direct parent class 00109 AbstractCellCycleModel::OutputCellCycleModelParameters(rParamsFile); 00110 }