00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2011 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 #ifndef LINEARSPRINGWITHVARIABLESPRINGCONSTANTSFORCE_HPP 00029 #define LINEARSPRINGWITHVARIABLESPRINGCONSTANTSFORCE_HPP 00030 00031 #include "GeneralisedLinearSpringForce.hpp" 00032 00033 #include "ChasteSerialization.hpp" 00034 #include <boost/serialization/base_object.hpp> 00035 00036 // Needed here to avoid serialization errors (on Boost<1.37) 00037 #include "ApcTwoHitCellMutationState.hpp" 00038 #include "BetaCateninOneHitCellMutationState.hpp" 00039 00043 template<unsigned DIM> 00044 class LinearSpringWithVariableSpringConstantsForce : public GeneralisedLinearSpringForce<DIM> 00045 { 00046 friend class TestLinearSpringWithVariableSpringConstantsForce; 00047 00048 private: 00049 00051 friend class boost::serialization::access; 00058 template<class Archive> 00059 void serialize(Archive & archive, const unsigned int version) 00060 { 00061 // If Archive is an output archive, then '&' resolves to '<<' 00062 // If Archive is an input archive, then '&' resolves to '>>' 00063 archive & boost::serialization::base_object<GeneralisedLinearSpringForce<DIM> >(*this); 00064 archive & mUseEdgeBasedSpringConstant; 00065 archive & mUseMutantSprings; 00066 archive & mMutantMutantMultiplier; 00067 archive & mNormalMutantMultiplier; 00068 archive & mUseBCatSprings; 00069 archive & mUseApoptoticSprings; 00070 archive & mBetaCatSpringScaler; 00071 archive & mApoptoticSpringTensionStiffness; 00072 archive & mApoptoticSpringCompressionStiffness; 00073 } 00074 00075 protected: 00076 00078 bool mUseEdgeBasedSpringConstant; 00079 00081 bool mUseMutantSprings; 00082 00084 double mMutantMutantMultiplier; 00085 00087 double mNormalMutantMultiplier; 00088 00090 bool mUseBCatSprings; 00091 00093 bool mUseApoptoticSprings; 00094 00096 double mBetaCatSpringScaler; 00097 00099 double mApoptoticSpringTensionStiffness; 00100 00102 double mApoptoticSpringCompressionStiffness; 00103 00104 public: 00105 00109 LinearSpringWithVariableSpringConstantsForce(); 00110 00114 ~LinearSpringWithVariableSpringConstantsForce(); 00115 00121 void SetEdgeBasedSpringConstant(bool useEdgeBasedSpringConstant); 00122 00131 void SetMutantSprings(bool useMutantSprings, double mutantMutantMultiplier=2, double normalMutantMultiplier=1.5); 00132 00138 void SetBetaCateninSprings(bool useBCatSprings); 00139 00145 void SetApoptoticSprings(bool useApoptoticSprings); 00146 00160 double VariableSpringConstantMultiplicationFactor(unsigned nodeAGlobalIndex, 00161 unsigned nodeBGlobalIndex, 00162 AbstractCellPopulation<DIM>& rCellPopulation, 00163 bool isCloserThanRestLength); 00164 00171 void AddForceContribution(std::vector<c_vector<double, DIM> >& rForces, 00172 AbstractCellPopulation<DIM>& rCellPopulation); 00173 00177 double GetBetaCatSpringScaler(); 00178 00184 void SetBetaCatSpringScaler(double betaCatSpringScaler); 00185 00189 double GetApoptoticSpringTensionStiffness(); 00190 00196 void SetApoptoticSpringTensionStiffness(double apoptoticSpringTensionStiffness); 00197 00201 double GetApoptoticSpringCompressionStiffness(); 00202 00208 void SetApoptoticSpringCompressionStiffness(double apoptoticSpringCompressionStiffness); 00209 00218 virtual void OutputForceParameters(out_stream& rParamsFile); 00219 }; 00220 00221 #include "SerializationExportWrapper.hpp" 00222 00223 EXPORT_TEMPLATE_CLASS_SAME_DIMS(LinearSpringWithVariableSpringConstantsForce) 00224 00225 00226 #endif /*LINEARSPRINGWITHVARIABLESPRINGCONSTANTSFORCE_HPP*/