00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2011 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 #ifndef RANDOMCELLKILLER_HPP_ 00029 #define RANDOMCELLKILLER_HPP_ 00030 00031 #include "AbstractCellKiller.hpp" 00032 #include "RandomNumberGenerator.hpp" 00033 00034 #include "ChasteSerialization.hpp" 00035 #include <boost/serialization/base_object.hpp> 00036 00037 00050 template<unsigned DIM> 00051 class RandomCellKiller : public AbstractCellKiller<DIM> 00052 { 00053 private: 00054 00059 double mProbabilityOfDeathInAnHour; 00060 00062 friend class boost::serialization::access; 00074 template<class Archive> 00075 void serialize(Archive & archive, const unsigned int version) 00076 { 00077 archive & boost::serialization::base_object<AbstractCellKiller<DIM> >(*this); 00078 00079 // Make sure the random number generator is archived 00080 RandomNumberGenerator* p_random_generator = RandomNumberGenerator::Instance(); 00081 archive & *p_random_generator; 00082 archive & p_random_generator; 00083 } 00084 00085 public: 00086 00093 RandomCellKiller(AbstractCellPopulation<DIM>* pCellPopulation, double probabilityOfDeathInAnHour); 00094 00098 double GetDeathProbabilityInAnHour() const; 00099 00105 void TestAndLabelSingleCellForApoptosis(CellPtr pCell); 00106 00111 void TestAndLabelCellsForApoptosisOrDeath(); 00112 00118 void OutputCellKillerParameters(out_stream& rParamsFile); 00119 }; 00120 00121 #include "SerializationExportWrapper.hpp" 00122 EXPORT_TEMPLATE_CLASS_SAME_DIMS(RandomCellKiller) 00123 00124 namespace boost 00125 { 00126 namespace serialization 00127 { 00131 template<class Archive, unsigned DIM> 00132 inline void save_construct_data( 00133 Archive & ar, const RandomCellKiller<DIM> * t, const BOOST_PFTO unsigned int file_version) 00134 { 00135 // Save data required to construct instance 00136 const AbstractCellPopulation<DIM>* const p_cell_population = t->GetCellPopulation(); 00137 ar << p_cell_population; 00138 double prob = t->GetDeathProbabilityInAnHour(); 00139 ar << prob; 00140 } 00141 00145 template<class Archive, unsigned DIM> 00146 inline void load_construct_data( 00147 Archive & ar, RandomCellKiller<DIM> * t, const unsigned int file_version) 00148 { 00149 // Retrieve data from archive required to construct new instance 00150 AbstractCellPopulation<DIM>* p_cell_population; 00151 ar >> p_cell_population; 00152 double prob; 00153 ar >> prob; 00154 00155 // Invoke inplace constructor to initialise instance 00156 ::new(t)RandomCellKiller<DIM>(p_cell_population, prob); 00157 } 00158 } 00159 } // namespace ... 00160 00161 #endif /*RANDOMCELLKILLER_HPP_*/