00001 /* 00002 00003 Copyright (c) 2005-2015, University of Oxford. 00004 All rights reserved. 00005 00006 University of Oxford means the Chancellor, Masters and Scholars of the 00007 University of Oxford, having an administrative office at Wellington 00008 Square, Oxford OX1 2JD, UK. 00009 00010 This file is part of Chaste. 00011 00012 Redistribution and use in source and binary forms, with or without 00013 modification, are permitted provided that the following conditions are met: 00014 * Redistributions of source code must retain the above copyright notice, 00015 this list of conditions and the following disclaimer. 00016 * Redistributions in binary form must reproduce the above copyright notice, 00017 this list of conditions and the following disclaimer in the documentation 00018 and/or other materials provided with the distribution. 00019 * Neither the name of the University of Oxford nor the names of its 00020 contributors may be used to endorse or promote products derived from this 00021 software without specific prior written permission. 00022 00023 THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" 00024 AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE 00025 IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE 00026 ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE 00027 LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR 00028 CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE 00029 GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) 00030 HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT 00031 LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT 00032 OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. 00033 00034 */ 00035 00036 #ifndef SIMPLEOXYGENBASEDCELLCYCLEMODEL_HPP_ 00037 #define SIMPLEOXYGENBASEDCELLCYCLEMODEL_HPP_ 00038 00039 #include "AbstractSimpleCellCycleModel.hpp" 00040 00051 class SimpleOxygenBasedCellCycleModel : public AbstractSimpleCellCycleModel 00052 { 00053 private: 00054 00055 friend class boost::serialization::access; 00061 template<class Archive> 00062 void serialize(Archive & archive, const unsigned int version) 00063 { 00064 archive & boost::serialization::base_object<AbstractSimpleCellCycleModel>(*this); 00065 archive & mCurrentHypoxicDuration; 00066 archive & mCurrentHypoxiaOnsetTime; 00067 archive & mHypoxicConcentration; 00068 archive & mQuiescentConcentration; 00069 archive & mCriticalHypoxicDuration; 00070 } 00071 00072 protected: 00073 00078 double mCurrentHypoxicDuration; 00079 00083 double mCurrentHypoxiaOnsetTime; 00084 00090 double mHypoxicConcentration; 00091 00097 double mQuiescentConcentration; 00098 00103 double mCriticalHypoxicDuration; 00104 00105 public: 00106 00110 SimpleOxygenBasedCellCycleModel(); 00111 00115 void UpdateCellCyclePhase(); 00116 00121 void UpdateHypoxicDuration(); 00122 00126 double GetCurrentHypoxicDuration(); 00127 00131 double GetCurrentHypoxiaOnsetTime(); 00132 00139 AbstractCellCycleModel* CreateCellCycleModel(); 00140 00144 double GetHypoxicConcentration(); 00145 00151 void SetHypoxicConcentration(double hypoxicConcentration); 00152 00156 double GetQuiescentConcentration(); 00157 00163 void SetQuiescentConcentration(double quiescentConcentration); 00164 00168 double GetCriticalHypoxicDuration(); 00169 00175 void SetCriticalHypoxicDuration(double criticalHypoxicDuration); 00176 00182 void SetCurrentHypoxiaOnsetTime(double currentHypoxiaOnsetTime); 00183 00189 virtual void OutputCellCycleModelParameters(out_stream& rParamsFile); 00190 }; 00191 00192 // Declare identifier for the serializer 00193 #include "SerializationExportWrapper.hpp" 00194 CHASTE_CLASS_EXPORT(SimpleOxygenBasedCellCycleModel) 00195 00196 #endif /*SIMPLEOXYGENBASEDCELLCYCLEMODEL_HPP_*/