00001 /* 00002 00003 Copyright (c) 2005-2015, University of Oxford. 00004 All rights reserved. 00005 00006 University of Oxford means the Chancellor, Masters and Scholars of the 00007 University of Oxford, having an administrative office at Wellington 00008 Square, Oxford OX1 2JD, UK. 00009 00010 This file is part of Chaste. 00011 00012 Redistribution and use in source and binary forms, with or without 00013 modification, are permitted provided that the following conditions are met: 00014 * Redistributions of source code must retain the above copyright notice, 00015 this list of conditions and the following disclaimer. 00016 * Redistributions in binary form must reproduce the above copyright notice, 00017 this list of conditions and the following disclaimer in the documentation 00018 and/or other materials provided with the distribution. 00019 * Neither the name of the University of Oxford nor the names of its 00020 contributors may be used to endorse or promote products derived from this 00021 software without specific prior written permission. 00022 00023 THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" 00024 AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE 00025 IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE 00026 ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE 00027 LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR 00028 CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE 00029 GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) 00030 HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT 00031 LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT 00032 OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. 00033 00034 */ 00035 00036 #include "StochasticDurationCellCycleModel.hpp" 00037 #include "Exception.hpp" 00038 #include "StemCellProliferativeType.hpp" 00039 #include "TransitCellProliferativeType.hpp" 00040 #include "DifferentiatedCellProliferativeType.hpp" 00041 00042 StochasticDurationCellCycleModel::StochasticDurationCellCycleModel() 00043 : AbstractSimpleCellCycleModel() 00044 { 00045 } 00046 00047 AbstractCellCycleModel* StochasticDurationCellCycleModel::CreateCellCycleModel() 00048 { 00049 // Create a new cell-cycle model 00050 StochasticDurationCellCycleModel* p_model = new StochasticDurationCellCycleModel(); 00051 00052 /* 00053 * Set each member variable of the new cell-cycle model that inherits 00054 * its value from the parent. 00055 * 00056 * Note 1: some of the new cell-cycle model's member variables (namely 00057 * mBirthTime, mCurrentCellCyclePhase, mReadyToDivide) will already have been 00058 * correctly initialized in its constructor. 00059 * 00060 * Note 2: one or more of the new cell-cycle model's member variables 00061 * may be set/overwritten as soon as InitialiseDaughterCell() is called on 00062 * the new cell-cycle model. 00063 * 00064 * Note 3: the member variable mDimension remains unset, since this cell-cycle 00065 * model does not need to know the spatial dimension, so if we were to call 00066 * SetDimension() on the new cell-cycle model an exception would be triggered; 00067 * hence we do not set this member variable. 00068 */ 00069 p_model->SetBirthTime(mBirthTime); 00070 p_model->SetMinimumGapDuration(mMinimumGapDuration); 00071 p_model->SetStemCellG1Duration(mStemCellG1Duration); 00072 p_model->SetTransitCellG1Duration(mTransitCellG1Duration); 00073 p_model->SetSDuration(mSDuration); 00074 p_model->SetG2Duration(mG2Duration); 00075 p_model->SetMDuration(mMDuration); 00076 00077 return p_model; 00078 } 00079 00080 void StochasticDurationCellCycleModel::SetG1Duration() 00081 { 00082 RandomNumberGenerator* p_gen = RandomNumberGenerator::Instance(); 00083 00084 if (mpCell->GetCellProliferativeType()->IsType<StemCellProliferativeType>()) 00085 { 00086 mG1Duration = GetStemCellG1Duration() + 2*p_gen->ranf(); // U[0,2] 00087 } 00088 else if (mpCell->GetCellProliferativeType()->IsType<TransitCellProliferativeType>()) 00089 { 00090 mG1Duration = GetTransitCellG1Duration() + 2*p_gen->ranf(); // U[0,2] 00091 } 00092 else if (mpCell->GetCellProliferativeType()->IsType<DifferentiatedCellProliferativeType>()) 00093 { 00094 mG1Duration = DBL_MAX; 00095 } 00096 else 00097 { 00098 NEVER_REACHED; 00099 } 00100 } 00101 00102 void StochasticDurationCellCycleModel::OutputCellCycleModelParameters(out_stream& rParamsFile) 00103 { 00104 // No new parameters to output, so just call method on direct parent class 00105 AbstractSimpleCellCycleModel::OutputCellCycleModelParameters(rParamsFile); 00106 } 00107 00108 // Serialization for Boost >= 1.36 00109 #include "SerializationExportWrapperForCpp.hpp" 00110 CHASTE_CLASS_EXPORT(StochasticDurationCellCycleModel)