BackwardEulerLuoRudyIModel1991.hpp

/*

Copyright (C) University of Oxford, 2005-2009

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This file is part of Chaste.

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under the terms of the GNU Lesser General Public License as published
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License is subject to the License being interpreted in accordance with
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*/
#ifndef _BACKWARDEULERLUORUDYIMODEL1991_HPP_
#define _BACKWARDEULERLUORUDYIMODEL1991_HPP_

#include "AbstractStimulusFunction.hpp"
#include "AbstractBackwardEulerCardiacCell.hpp"

#include <vector>

class BackwardEulerLuoRudyIModel1991 : public AbstractBackwardEulerCardiacCell<1>
{
private:
    static const double membrane_C = 1.0;
    static const double membrane_F = 96484.6;
    static const double membrane_R = 8314;
    static const double membrane_T = 310.0;    
    static const double background_current_E_b = -59.87;
    static const double background_current_g_b = 0.03921;    
    static const double fast_sodium_current_g_Na = 23.0;
    static const double ionic_concentrations_Ki = 145.0;
    static const double ionic_concentrations_Ko = 5.4;
    static const double ionic_concentrations_Nai = 18.0;
    static const double ionic_concentrations_Nao = 140.0;
    static const double plateau_potassium_current_g_Kp = 0.0183;
    static const double time_dependent_potassium_current_PR_NaK = 0.01833;

    double fast_sodium_current_E_Na;

    
public:
    // Constructor
    BackwardEulerLuoRudyIModel1991(AbstractStimulusFunction *pIntracellularStimulus);
                                   
    // Constructor with the same signature as the forward cell models
    BackwardEulerLuoRudyIModel1991(AbstractIvpOdeSolver *pSolver,
                                   AbstractStimulusFunction *pIntracellularStimulus);
                                   
    // Destructor
    ~BackwardEulerLuoRudyIModel1991();
    
    void Init();
    
protected:
    void ComputeOneStepExceptVoltage(double tStart);
    
    void UpdateTransmembranePotential(double time);
    
public:
    void ComputeResidual(const double rCurrentGuess[1], double rResidual[1]);
    void ComputeJacobian(const double rCurrentGuess[1], double rJacobian[1][1]);
    
    double GetIIonic();
    
    void VerifyStateVariables();

    double GetIntracellularCalciumConcentration();
};

#endif // _BACKWARDEULERLUORUDYIMODEL1991_HPP_

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