LinearSpringWithVariableSpringConstantsForce< DIM > Class Template Reference

#include <LinearSpringWithVariableSpringConstantsForce.hpp>

Inheritance diagram for LinearSpringWithVariableSpringConstantsForce< DIM >:

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Collaboration diagram for LinearSpringWithVariableSpringConstantsForce< DIM >:

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List of all members.

Public Member Functions

 LinearSpringWithVariableSpringConstantsForce ()
 ~LinearSpringWithVariableSpringConstantsForce ()
void SetEdgeBasedSpringConstant (bool useEdgeBasedSpringConstant)
void SetMutantSprings (bool useMutantSprings, double mutantMutantMultiplier=2, double normalMutantMultiplier=1.5)
void SetBetaCateninSprings (bool useBCatSprings)
void SetApoptoticSprings (bool useApoptoticSprings)
double VariableSpringConstantMultiplicationFactor (unsigned nodeAGlobalIndex, unsigned nodeBGlobalIndex, AbstractTissue< DIM > &rTissue, bool isCloserThanRestLength)
void AddForceContribution (std::vector< c_vector< double, DIM > > &rForces, AbstractTissue< DIM > &rTissue)

Protected Attributes

bool mUseEdgeBasedSpringConstant
bool mUseMutantSprings
double mMutantMutantMultiplier
double mNormalMutantMultiplier
bool mUseBCatSprings
bool mUseApoptoticSprings

Private Member Functions

template<class Archive>
void serialize (Archive &archive, const unsigned int version)

Friends

class TestForces
class boost::serialization::access

Detailed Description

template<unsigned DIM>
class LinearSpringWithVariableSpringConstantsForce< DIM >

A subclass of GeneralisedLinearSpringForce with variable spring constants.

Definition at line 40 of file LinearSpringWithVariableSpringConstantsForce.hpp.

Constructor & Destructor Documentation

template<unsigned DIM>
LinearSpringWithVariableSpringConstantsForce< DIM >::LinearSpringWithVariableSpringConstantsForce (  )  [inline]

Constructor.

Definition at line 35 of file LinearSpringWithVariableSpringConstantsForce.cpp.

References LinearSpringWithVariableSpringConstantsForce< DIM >::mMutantMutantMultiplier, LinearSpringWithVariableSpringConstantsForce< DIM >::mNormalMutantMultiplier, LinearSpringWithVariableSpringConstantsForce< DIM >::mUseApoptoticSprings, LinearSpringWithVariableSpringConstantsForce< DIM >::mUseBCatSprings, LinearSpringWithVariableSpringConstantsForce< DIM >::mUseEdgeBasedSpringConstant, and LinearSpringWithVariableSpringConstantsForce< DIM >::mUseMutantSprings.

template<unsigned DIM>
LinearSpringWithVariableSpringConstantsForce< DIM >::~LinearSpringWithVariableSpringConstantsForce (  )  [inline]

Destructor.

Definition at line 54 of file LinearSpringWithVariableSpringConstantsForce.cpp.

Member Function Documentation

template<unsigned DIM>
template<class Archive>
void LinearSpringWithVariableSpringConstantsForce< DIM >::serialize ( Archive &  archive,
const unsigned int  version 
) [inline, private]

Archive the object and its member variables.

Parameters:
archive 
version 

Reimplemented from GeneralisedLinearSpringForce< DIM >.

Definition at line 55 of file LinearSpringWithVariableSpringConstantsForce.hpp.

References LinearSpringWithVariableSpringConstantsForce< DIM >::mMutantMutantMultiplier, LinearSpringWithVariableSpringConstantsForce< DIM >::mNormalMutantMultiplier, LinearSpringWithVariableSpringConstantsForce< DIM >::mUseApoptoticSprings, LinearSpringWithVariableSpringConstantsForce< DIM >::mUseBCatSprings, LinearSpringWithVariableSpringConstantsForce< DIM >::mUseEdgeBasedSpringConstant, and LinearSpringWithVariableSpringConstantsForce< DIM >::mUseMutantSprings.

template<unsigned DIM>
void LinearSpringWithVariableSpringConstantsForce< DIM >::SetEdgeBasedSpringConstant ( bool  useEdgeBasedSpringConstant  )  [inline]

Set whether to use an edge-based spring constant.

Parameters:
useEdgeBasedSpringConstant 

Definition at line 59 of file LinearSpringWithVariableSpringConstantsForce.cpp.

References LinearSpringWithVariableSpringConstantsForce< DIM >::mUseEdgeBasedSpringConstant.

template<unsigned DIM>
void LinearSpringWithVariableSpringConstantsForce< DIM >::SetMutantSprings ( bool  useMutantSprings,
double  mutantMutantMultiplier = 2,
double  normalMutantMultiplier = 1.5 
) [inline]

Use different spring strengths depending on two cells: Normal-normal, Normal-mutant, mutant-mutant

Parameters:
useMutantSprings whether to use mutant springs
mutantMutantMultiplier the multiplier for springs connecting two mutant cells
normalMutantMultiplier the multiplier for springs connecting a mutant cell with a normal cell

Definition at line 66 of file LinearSpringWithVariableSpringConstantsForce.cpp.

References LinearSpringWithVariableSpringConstantsForce< DIM >::mMutantMutantMultiplier, LinearSpringWithVariableSpringConstantsForce< DIM >::mNormalMutantMultiplier, and LinearSpringWithVariableSpringConstantsForce< DIM >::mUseMutantSprings.

template<unsigned DIM>
void LinearSpringWithVariableSpringConstantsForce< DIM >::SetBetaCateninSprings ( bool  useBCatSprings  )  [inline]

Use the amount of beta-catenin on an edge to find spring constant.

Parameters:
useBCatSprings whether to use beta-catenin-dependent spring stiffness

Definition at line 74 of file LinearSpringWithVariableSpringConstantsForce.cpp.

References LinearSpringWithVariableSpringConstantsForce< DIM >::mUseBCatSprings.

template<unsigned DIM>
void LinearSpringWithVariableSpringConstantsForce< DIM >::SetApoptoticSprings ( bool  useApoptoticSprings  )  [inline]

Set spring stiffness to be dependent on whether cells are apoptotic

Parameters:
useApoptoticSprings whether to have apoptosis-dependent spring stiffness

Definition at line 80 of file LinearSpringWithVariableSpringConstantsForce.cpp.

References LinearSpringWithVariableSpringConstantsForce< DIM >::mUseApoptoticSprings.

template<unsigned DIM>
double LinearSpringWithVariableSpringConstantsForce< DIM >::VariableSpringConstantMultiplicationFactor ( unsigned  nodeAGlobalIndex,
unsigned  nodeBGlobalIndex,
AbstractTissue< DIM > &  rTissue,
bool  isCloserThanRestLength 
) [inline, virtual]

Return a multiplication factor for the spring constant, which may depend on whether the given pair of neighbouring cells are e.g. undergoing apoptosis, have mutations, or experience variable levels of beta catenin.

Parameters:
nodeAGlobalIndex index of one neighbouring node
nodeBGlobalIndex index of the other neighbouring node
rTissue the tissue
isCloserThanRestLength whether the neighbouring nodes lie closer than the rest length of their connecting spring
Returns:
the multiplication factor.

Reimplemented from GeneralisedLinearSpringForce< DIM >.

Definition at line 86 of file LinearSpringWithVariableSpringConstantsForce.cpp.

References CancerParameters::GetApoptoticSpringCompressionStiffness(), CancerParameters::GetApoptoticSpringTensionStiffness(), CancerParameters::GetBetaCatSpringScaler(), TissueCell::GetCellCycleModel(), TissueCell::GetCellType(), IngeWntSwatCellCycleModel::GetMembraneBoundBetaCateninLevel(), TissueCell::GetMutationState(), CancerParameters::GetSpringStiffness(), AbstractTissue< DIM >::HasMesh(), CancerParameters::Instance(), LinearSpringWithVariableSpringConstantsForce< DIM >::mMutantMutantMultiplier, LinearSpringWithVariableSpringConstantsForce< DIM >::mNormalMutantMultiplier, LinearSpringWithVariableSpringConstantsForce< DIM >::mUseApoptoticSprings, LinearSpringWithVariableSpringConstantsForce< DIM >::mUseBCatSprings, LinearSpringWithVariableSpringConstantsForce< DIM >::mUseEdgeBasedSpringConstant, LinearSpringWithVariableSpringConstantsForce< DIM >::mUseMutantSprings, AbstractTissue< DIM >::rGetCellUsingLocationIndex(), and GeneralisedLinearSpringForce< DIM >::VariableSpringConstantMultiplicationFactor().

template<unsigned DIM>
void LinearSpringWithVariableSpringConstantsForce< DIM >::AddForceContribution ( std::vector< c_vector< double, DIM > > &  rForces,
AbstractTissue< DIM > &  rTissue 
) [inline, virtual]

Overridden AddForceContribution method.

Parameters:
rForces reference to vector of forces on nodes
rTissue reference to the tissue

Reimplemented from GeneralisedLinearSpringForce< DIM >.

Definition at line 205 of file LinearSpringWithVariableSpringConstantsForce.cpp.

References GeneralisedLinearSpringForce< DIM >::CalculateForceBetweenNodes().

Friends And Related Function Documentation

template<unsigned DIM>
friend class boost::serialization::access [friend]

Needed for serialization.

Reimplemented from GeneralisedLinearSpringForce< DIM >.

Definition at line 47 of file LinearSpringWithVariableSpringConstantsForce.hpp.

Member Data Documentation

template<unsigned DIM>
bool LinearSpringWithVariableSpringConstantsForce< DIM >::mUseEdgeBasedSpringConstant [protected]

Whether to use spring constant proportional to cell-cell contact length/area (defaults to false)

Definition at line 71 of file LinearSpringWithVariableSpringConstantsForce.hpp.

Referenced by LinearSpringWithVariableSpringConstantsForce< DIM >::LinearSpringWithVariableSpringConstantsForce(), LinearSpringWithVariableSpringConstantsForce< DIM >::serialize(), LinearSpringWithVariableSpringConstantsForce< DIM >::SetEdgeBasedSpringConstant(), and LinearSpringWithVariableSpringConstantsForce< DIM >::VariableSpringConstantMultiplicationFactor().

template<unsigned DIM>
bool LinearSpringWithVariableSpringConstantsForce< DIM >::mUseMutantSprings [protected]

Whether to use different stiffnesses depending on whether either cell is a mutant

Definition at line 74 of file LinearSpringWithVariableSpringConstantsForce.hpp.

Referenced by LinearSpringWithVariableSpringConstantsForce< DIM >::LinearSpringWithVariableSpringConstantsForce(), LinearSpringWithVariableSpringConstantsForce< DIM >::serialize(), LinearSpringWithVariableSpringConstantsForce< DIM >::SetMutantSprings(), and LinearSpringWithVariableSpringConstantsForce< DIM >::VariableSpringConstantMultiplicationFactor().

template<unsigned DIM>
double LinearSpringWithVariableSpringConstantsForce< DIM >::mMutantMutantMultiplier [protected]

Multiplier for spring stiffness if mutant

Definition at line 77 of file LinearSpringWithVariableSpringConstantsForce.hpp.

Referenced by LinearSpringWithVariableSpringConstantsForce< DIM >::LinearSpringWithVariableSpringConstantsForce(), LinearSpringWithVariableSpringConstantsForce< DIM >::serialize(), LinearSpringWithVariableSpringConstantsForce< DIM >::SetMutantSprings(), and LinearSpringWithVariableSpringConstantsForce< DIM >::VariableSpringConstantMultiplicationFactor().

template<unsigned DIM>
double LinearSpringWithVariableSpringConstantsForce< DIM >::mNormalMutantMultiplier [protected]

Multiplier for spring stiffness if mutant

Definition at line 80 of file LinearSpringWithVariableSpringConstantsForce.hpp.

Referenced by LinearSpringWithVariableSpringConstantsForce< DIM >::LinearSpringWithVariableSpringConstantsForce(), LinearSpringWithVariableSpringConstantsForce< DIM >::serialize(), LinearSpringWithVariableSpringConstantsForce< DIM >::SetMutantSprings(), and LinearSpringWithVariableSpringConstantsForce< DIM >::VariableSpringConstantMultiplicationFactor().

template<unsigned DIM>
bool LinearSpringWithVariableSpringConstantsForce< DIM >::mUseBCatSprings [protected]

Use springs which are dependent on beta-catenin levels

Definition at line 83 of file LinearSpringWithVariableSpringConstantsForce.hpp.

Referenced by LinearSpringWithVariableSpringConstantsForce< DIM >::LinearSpringWithVariableSpringConstantsForce(), LinearSpringWithVariableSpringConstantsForce< DIM >::serialize(), LinearSpringWithVariableSpringConstantsForce< DIM >::SetBetaCateninSprings(), and LinearSpringWithVariableSpringConstantsForce< DIM >::VariableSpringConstantMultiplicationFactor().

template<unsigned DIM>
bool LinearSpringWithVariableSpringConstantsForce< DIM >::mUseApoptoticSprings [protected]

Use springs which are dependent on whether cells are apoptotic

Definition at line 86 of file LinearSpringWithVariableSpringConstantsForce.hpp.

Referenced by LinearSpringWithVariableSpringConstantsForce< DIM >::LinearSpringWithVariableSpringConstantsForce(), LinearSpringWithVariableSpringConstantsForce< DIM >::serialize(), LinearSpringWithVariableSpringConstantsForce< DIM >::SetApoptoticSprings(), and LinearSpringWithVariableSpringConstantsForce< DIM >::VariableSpringConstantMultiplicationFactor().

The documentation for this class was generated from the following files:
Generated on Wed Mar 18 12:52:34 2009 for Chaste by  doxygen 1.5.5