SimpleWntCellCycleModel Class Reference

#include <SimpleWntCellCycleModel.hpp>

Inheritance diagram for SimpleWntCellCycleModel:

Collaboration diagram for SimpleWntCellCycleModel:

List of all members.

Public Member Functions

SimpleWntCellCycleModel (bool useCellTypeDependentG1Duration=false)

void UpdateCellCyclePhase ()

void ResetForDivision ()

void InitialiseDaughterCell ()

AbstractCellCycleModel * CreateDaughterCellCycleModel ()

Protected Member Functions

void SetG1Duration ()

SimpleWntCellCycleModel (double g1Duration, bool useCellTypeDependentG1Duration=false)

Private Member Functions

template<class Archive>

void serialize (Archive &archive, const unsigned int version)

Private Attributes

bool mUseCellTypeDependentG1Duration

Friends

class boost::serialization::access

Detailed Description

Simple Wnt-dependent cell cycle model

Definition at line 39 of file SimpleWntCellCycleModel.hpp.

Constructor & Destructor Documentation

SimpleWntCellCycleModel::SimpleWntCellCycleModel	(	double	g1Duration,
		bool	useCellTypeDependentG1Duration = `false`
	)			`[protected]`

Private constructor for identical cells.

Parameters:

	g1Duration	The duration of the G1 phase
	useCellTypeDependentG1Duration	Whether the duration of the G1 phase is dependent on cell type

Definition at line 31 of file SimpleWntCellCycleModel.cpp.

Referenced by CreateDaughterCellCycleModel().

SimpleWntCellCycleModel::SimpleWntCellCycleModel ( bool useCellTypeDependentG1Duration = false )

Constructor - just a default, mBirthTime is now set in the AbstractCellCycleModel class. mG1Duration is set very high, it is set for the individual cells when InitialiseDaughterCell is called.

Parameters:

useCellTypeDependentG1Duration

Whether the duration of the G1 phase is dependent on cell type

Definition at line 39 of file SimpleWntCellCycleModel.cpp.

Member Function Documentation

template<class Archive>

void SimpleWntCellCycleModel::serialize	(	Archive &	archive,
		const unsigned int	version
	)			`[inline, private]`

Archive the cell cycle model, never used directly - boost uses this.

Parameters:

	archive
	version

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 52 of file SimpleWntCellCycleModel.hpp.

References mUseCellTypeDependentG1Duration.

void SimpleWntCellCycleModel::SetG1Duration ( ) [protected, virtual]

Stochastically set the G1 duration. The G1 duration is taken from a normal distribution whose mean is the G1 duration given in CancerParameters for the cell type and whose standard deviation is 1.

Called on cell creation at the start of a simulation, and for both parent and daughter cells at cell division.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 52 of file SimpleWntCellCycleModel.cpp.

References TissueCell::GetCellType(), CancerParameters::GetMinimumGapDuration(), CancerParameters::GetStemCellG1Duration(), CancerParameters::GetTransitCellG1Duration(), CancerParameters::Instance(), AbstractCellCycleModel::mG1Duration, AbstractCellCycleModel::mpCell, and mUseCellTypeDependentG1Duration.

void SimpleWntCellCycleModel::UpdateCellCyclePhase ( ) [virtual]

Overridden UpdateCellCyclePhase() method.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 90 of file SimpleWntCellCycleModel.cpp.

References TissueCell::GetMutationState(), WntConcentration::GetType(), WntConcentration::GetWntLevel(), CancerParameters::GetWntStemThreshold(), CancerParameters::GetWntTransitThreshold(), WntConcentration::Instance(), CancerParameters::Instance(), AbstractCellCycleModel::mCurrentCellCyclePhase, AbstractCellCycleModel::mpCell, TissueCell::SetCellType(), and AbstractSimpleCellCycleModel::UpdateCellCyclePhase().

void SimpleWntCellCycleModel::ResetForDivision ( ) [virtual]

Overridden ResetForDivision() method.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 167 of file SimpleWntCellCycleModel.cpp.

References AbstractSimpleCellCycleModel::ResetForDivision().

void SimpleWntCellCycleModel::InitialiseDaughterCell ( ) [virtual]

Overridden InitialiseDaughterCell() method.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 173 of file SimpleWntCellCycleModel.cpp.

References AbstractSimpleCellCycleModel::InitialiseDaughterCell(), WntConcentration::Instance(), AbstractCellCycleModel::mpCell, and TissueCell::SetCellType().

AbstractCellCycleModel * SimpleWntCellCycleModel::CreateDaughterCellCycleModel ( ) [virtual]

Overridden builder method to create new instances of the cell cycle model.

Implements AbstractCellCycleModel.

Definition at line 45 of file SimpleWntCellCycleModel.cpp.

References AbstractCellCycleModel::mG1Duration, mUseCellTypeDependentG1Duration, and SimpleWntCellCycleModel().

Friends And Related Function Documentation

friend class boost::serialization::access [friend]

Needed for serialization.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 44 of file SimpleWntCellCycleModel.hpp.

Member Data Documentation

bool SimpleWntCellCycleModel::mUseCellTypeDependentG1Duration [private]

Whether to use different mean G1 durations for different cell types. For use in SetG1Duration().

Definition at line 66 of file SimpleWntCellCycleModel.hpp.

Referenced by CreateDaughterCellCycleModel(), serialize(), and SetG1Duration().

The documentation for this class was generated from the following files:

/tmp/release_1/cancer/src/tissue/cell/cycle/SimpleWntCellCycleModel.hpp
/tmp/release_1/cancer/src/tissue/cell/cycle/SimpleWntCellCycleModel.cpp


Public Member Functions
	SimpleWntCellCycleModel (bool useCellTypeDependentG1Duration=false)
void	UpdateCellCyclePhase ()
void	ResetForDivision ()
void	InitialiseDaughterCell ()
AbstractCellCycleModel *	CreateDaughterCellCycleModel ()
Protected Member Functions
void	SetG1Duration ()
	SimpleWntCellCycleModel (double g1Duration, bool useCellTypeDependentG1Duration=false)
Private Member Functions
template<class Archive>
void	serialize (Archive &archive, const unsigned int version)
Private Attributes
bool	mUseCellTypeDependentG1Duration
Friends
class	boost::serialization::access