TenTusscher2006OdeSystem Class Reference

#include <TenTusscher2006OdeSystem.hpp>

Inheritance diagram for TenTusscher2006OdeSystem:

Collaboration diagram for TenTusscher2006OdeSystem:

List of all members.

Public Member Functions

TenTusscher2006OdeSystem (AbstractIvpOdeSolver *pSolver, AbstractStimulusFunction *pIntracellularStimulus)

~TenTusscher2006OdeSystem ()

void EvaluateYDerivatives (double time, const std::vector< double > &rY, std::vector< double > &rDY)

void SetScaleFactorGks (double sfgks)

void SetScaleFactorIto (double sfito)

void SetScaleFactorGkr (double sfgkr)

double GetIIonic ()

Private Member Functions

void VerifyStateVariables ()

Private Attributes

double mScaleFactorGks

double mScaleFactorIto

double mScaleFactorGkr

double L_type_Ca_current_d_gate_alpha_d

double L_type_Ca_current_d_gate_beta_d

double L_type_Ca_current_d_gate_d_inf

double L_type_Ca_current_d_gate_gamma_d

double L_type_Ca_current_d_gate_tau_d

double L_type_Ca_current_f2_gate_f2_inf

double L_type_Ca_current_f2_gate_tau_f2

double L_type_Ca_current_fCass_gate_fCass_inf

double L_type_Ca_current_fCass_gate_tau_fCass

double L_type_Ca_current_f_gate_f_inf

double L_type_Ca_current_f_gate_tau_f

double L_type_Ca_current_i_CaL

double calcium_background_current_i_b_Ca

double calcium_dynamics_Ca_i_bufc

double calcium_dynamics_Ca_sr_bufsr

double calcium_dynamics_Ca_ss_bufss

double calcium_dynamics_O

double calcium_dynamics_i_leak

double calcium_dynamics_i_rel

double calcium_dynamics_i_up

double calcium_dynamics_i_xfer

double calcium_dynamics_k1

double calcium_dynamics_k2

double calcium_dynamics_kcasr

double calcium_pump_current_i_p_Ca

double fast_sodium_current_h_gate_alpha_h

double fast_sodium_current_h_gate_beta_h

double fast_sodium_current_h_gate_h_inf

double fast_sodium_current_h_gate_tau_h

double fast_sodium_current_i_Na

double fast_sodium_current_j_gate_alpha_j

double fast_sodium_current_j_gate_beta_j

double fast_sodium_current_j_gate_j_inf

double fast_sodium_current_j_gate_tau_j

double fast_sodium_current_m_gate_alpha_m

double fast_sodium_current_m_gate_beta_m

double fast_sodium_current_m_gate_m_inf

double fast_sodium_current_m_gate_tau_m

double inward_rectifier_potassium_current_alpha_K1

double inward_rectifier_potassium_current_beta_K1

double inward_rectifier_potassium_current_i_K1

double inward_rectifier_potassium_current_xK1_inf

double potassium_pump_current_i_p_K

double rapid_time_dependent_potassium_current_Xr1_gate_alpha_xr1

double rapid_time_dependent_potassium_current_Xr1_gate_beta_xr1

double rapid_time_dependent_potassium_current_Xr1_gate_tau_xr1

double rapid_time_dependent_potassium_current_Xr1_gate_xr1_inf

double rapid_time_dependent_potassium_current_Xr2_gate_alpha_xr2

double rapid_time_dependent_potassium_current_Xr2_gate_beta_xr2

double rapid_time_dependent_potassium_current_Xr2_gate_tau_xr2

double rapid_time_dependent_potassium_current_Xr2_gate_xr2_inf

double rapid_time_dependent_potassium_current_i_Kr

double reversal_potentials_E_Ca

double reversal_potentials_E_K

double reversal_potentials_E_Ks

double reversal_potentials_E_Na

double slow_time_dependent_potassium_current_Xs_gate_alpha_xs

double slow_time_dependent_potassium_current_Xs_gate_beta_xs

double slow_time_dependent_potassium_current_Xs_gate_tau_xs

double slow_time_dependent_potassium_current_Xs_gate_xs_inf

double slow_time_dependent_potassium_current_i_Ks

double sodium_background_current_i_b_Na

double sodium_calcium_exchanger_current_i_NaCa

double sodium_potassium_pump_current_i_NaK

double transient_outward_current_i_to

double transient_outward_current_r_gate_r_inf

double transient_outward_current_r_gate_tau_r

double transient_outward_current_s_gate_s_inf

double transient_outward_current_s_gate_tau_s

Static Private Attributes

static const double L_type_Ca_current_g_CaL = 0.0000398

static const double calcium_background_current_g_bca = 0.000592

static const double calcium_dynamics_Buf_c = 0.2

static const double calcium_dynamics_Buf_sr = 10.0

static const double calcium_dynamics_Buf_ss = 0.4

static const double calcium_dynamics_Ca_o = 2.0

static const double calcium_dynamics_EC = 1.5

static const double calcium_dynamics_K_buf_c = 0.001

static const double calcium_dynamics_K_buf_sr = 0.3

static const double calcium_dynamics_K_buf_ss = 0.00025

static const double calcium_dynamics_K_up = 0.00025

static const double calcium_dynamics_V_leak = 0.00036

static const double calcium_dynamics_V_rel = 0.102

static const double calcium_dynamics_V_sr = 0.001094

static const double calcium_dynamics_V_ss = 0.00005468

static const double calcium_dynamics_V_xfer = 0.0038

static const double calcium_dynamics_Vmax_up = 0.006375

static const double calcium_dynamics_k1_prime = 0.15

static const double calcium_dynamics_k2_prime = 0.045

static const double calcium_dynamics_k3 = 0.06

static const double calcium_dynamics_k4 = 0.005

static const double calcium_dynamics_max_sr = 2.5

static const double calcium_dynamics_min_sr = 1.0

static const double calcium_pump_current_K_pCa = 0.0005

static const double calcium_pump_current_g_pCa = 0.1238

static const double fast_sodium_current_g_Na = 14.838

static const double inward_rectifier_potassium_current_g_K1 = 5.405

static const double membrane_Cm = 0.185

static const double membrane_F = 96485.3415

static const double membrane_R = 8314.472

static const double membrane_T = 310.0

static const double membrane_V_c = 0.016404

static const double potassium_dynamics_K_o = 5.4

static const double potassium_pump_current_g_pK = 0.0146

static const double rapid_time_dependent_potassium_current_g_Kr = 0.153

static const double reversal_potentials_P_kna = 0.03

static const double slow_time_dependent_potassium_current_g_Ks = 0.392

static const double sodium_background_current_g_bna = 0.00029

static const double sodium_calcium_exchanger_current_K_NaCa = 1000.0

static const double sodium_calcium_exchanger_current_K_sat = 0.1

static const double sodium_calcium_exchanger_current_Km_Ca = 1.38

static const double sodium_calcium_exchanger_current_Km_Nai = 87.5

static const double sodium_calcium_exchanger_current_alpha = 2.5

static const double sodium_calcium_exchanger_current_gamma = 0.35

static const double sodium_dynamics_Na_o = 140.0

static const double sodium_potassium_pump_current_K_mNa = 40.0

static const double sodium_potassium_pump_current_K_mk = 1.0

static const double sodium_potassium_pump_current_P_NaK = 2.724

static const double transient_outward_current_g_to = 0.294

Detailed Description

This class sets up the equations for the TenTusscher 2006 model. This is for an epicardial cell.

Definition at line 39 of file TenTusscher2006OdeSystem.hpp.

Constructor & Destructor Documentation

TenTusscher2006OdeSystem::TenTusscher2006OdeSystem	(	AbstractIvpOdeSolver *	pSolver,
		AbstractStimulusFunction *	pIntracellularStimulus
	)

Constructor

Definition at line 36 of file TenTusscher2006OdeSystem.cpp.

References AbstractCardiacCell::Init(), OdeSystemInformation< ODE_SYSTEM >::Instance(), AbstractOdeSystem::mpSystemInfo, mScaleFactorGkr, mScaleFactorGks, and mScaleFactorIto.

TenTusscher2006OdeSystem::~TenTusscher2006OdeSystem ( void )

Destructor

Definition at line 52 of file TenTusscher2006OdeSystem.cpp.

Member Function Documentation

void TenTusscher2006OdeSystem::VerifyStateVariables ( ) [private, virtual]

Empty method which can be over-ridden in concrete cell class which should go through the current state vector and go range checking on the values (eg check that concentrations are positive and gating variables are between zero and one). This method is called in the ComputeExceptVoltage method.

Reimplemented from AbstractCardiacCell.

Definition at line 406 of file TenTusscher2006OdeSystem.cpp.

References AbstractOdeSystem::DumpState().

Referenced by EvaluateYDerivatives().

void TenTusscher2006OdeSystem::EvaluateYDerivatives	(	double	time,
		const std::vector< double > &	rY,
		std::vector< double > &	rDY
	)			`[virtual]`

This method will compute the RHS of the TenTusscher model

Fill in a vector representing the RHS of the TenTusscher2006 system of Odes at each time step, y' = [y1' ... yn']. Some ODE solver will call this function repeatedly to solve for y = [y1 ... yn].

Parameters:

	time	the current time, in milliseconds
	rY	current values of the state variables
	rDY	to be filled in with derivatives

Implements AbstractOdeSystem.

Definition at line 77 of file TenTusscher2006OdeSystem.cpp.

References mScaleFactorGkr, mScaleFactorGks, mScaleFactorIto, and VerifyStateVariables().

void TenTusscher2006OdeSystem::SetScaleFactorGks ( double sfgks )

Set the scale factor for Gks in order to differentiate epi M and endo cells

Definition at line 56 of file TenTusscher2006OdeSystem.cpp.

References mScaleFactorGks.

void TenTusscher2006OdeSystem::SetScaleFactorIto ( double sfito )

Set the scale factor for Gks in order to differentiate epi M and endo cells

Definition at line 60 of file TenTusscher2006OdeSystem.cpp.

References mScaleFactorIto.

void TenTusscher2006OdeSystem::SetScaleFactorGkr ( double sfgkr )

Set the scale factor for Gkr (might be useful for simulating LQT2)

Definition at line 64 of file TenTusscher2006OdeSystem.cpp.

References mScaleFactorGkr.

double TenTusscher2006OdeSystem::GetIIonic ( ) [virtual]

Returns the ionic current

Implements AbstractCardiacCell.

Definition at line 252 of file TenTusscher2006OdeSystem.cpp.

References mScaleFactorGkr, mScaleFactorGks, and mScaleFactorIto.

Member Data Documentation

double TenTusscher2006OdeSystem::mScaleFactorGks [private]

Scale factor for Gks

Definition at line 44 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), GetIIonic(), SetScaleFactorGks(), and TenTusscher2006OdeSystem().

double TenTusscher2006OdeSystem::mScaleFactorIto [private]

Scale factor for Gto

Definition at line 46 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), GetIIonic(), SetScaleFactorIto(), and TenTusscher2006OdeSystem().

double TenTusscher2006OdeSystem::mScaleFactorGkr [private]

Scale factor for Gkr

Definition at line 48 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), GetIIonic(), SetScaleFactorGkr(), and TenTusscher2006OdeSystem().

The documentation for this class was generated from the following files:

/tmp/release_1/heart/src/odes/TenTusscher2006OdeSystem.hpp
/tmp/release_1/heart/src/odes/TenTusscher2006OdeSystem.cpp


Public Member Functions
	TenTusscher2006OdeSystem (AbstractIvpOdeSolver pSolver, AbstractStimulusFunction pIntracellularStimulus)
	~TenTusscher2006OdeSystem ()
void	EvaluateYDerivatives (double time, const std::vector< double > &rY, std::vector< double > &rDY)
void	SetScaleFactorGks (double sfgks)
void	SetScaleFactorIto (double sfito)
void	SetScaleFactorGkr (double sfgkr)
double	GetIIonic ()
Private Member Functions
void	VerifyStateVariables ()
Private Attributes
double	mScaleFactorGks
double	mScaleFactorIto
double	mScaleFactorGkr
double	L_type_Ca_current_d_gate_alpha_d
double	L_type_Ca_current_d_gate_beta_d
double	L_type_Ca_current_d_gate_d_inf
double	L_type_Ca_current_d_gate_gamma_d
double	L_type_Ca_current_d_gate_tau_d
double	L_type_Ca_current_f2_gate_f2_inf
double	L_type_Ca_current_f2_gate_tau_f2
double	L_type_Ca_current_fCass_gate_fCass_inf
double	L_type_Ca_current_fCass_gate_tau_fCass
double	L_type_Ca_current_f_gate_f_inf
double	L_type_Ca_current_f_gate_tau_f
double	L_type_Ca_current_i_CaL
double	calcium_background_current_i_b_Ca
double	calcium_dynamics_Ca_i_bufc
double	calcium_dynamics_Ca_sr_bufsr
double	calcium_dynamics_Ca_ss_bufss
double	calcium_dynamics_O
double	calcium_dynamics_i_leak
double	calcium_dynamics_i_rel
double	calcium_dynamics_i_up
double	calcium_dynamics_i_xfer
double	calcium_dynamics_k1
double	calcium_dynamics_k2
double	calcium_dynamics_kcasr
double	calcium_pump_current_i_p_Ca
double	fast_sodium_current_h_gate_alpha_h
double	fast_sodium_current_h_gate_beta_h
double	fast_sodium_current_h_gate_h_inf
double	fast_sodium_current_h_gate_tau_h
double	fast_sodium_current_i_Na
double	fast_sodium_current_j_gate_alpha_j
double	fast_sodium_current_j_gate_beta_j
double	fast_sodium_current_j_gate_j_inf
double	fast_sodium_current_j_gate_tau_j
double	fast_sodium_current_m_gate_alpha_m
double	fast_sodium_current_m_gate_beta_m
double	fast_sodium_current_m_gate_m_inf
double	fast_sodium_current_m_gate_tau_m
double	inward_rectifier_potassium_current_alpha_K1
double	inward_rectifier_potassium_current_beta_K1
double	inward_rectifier_potassium_current_i_K1
double	inward_rectifier_potassium_current_xK1_inf
double	potassium_pump_current_i_p_K
double	rapid_time_dependent_potassium_current_Xr1_gate_alpha_xr1
double	rapid_time_dependent_potassium_current_Xr1_gate_beta_xr1
double	rapid_time_dependent_potassium_current_Xr1_gate_tau_xr1
double	rapid_time_dependent_potassium_current_Xr1_gate_xr1_inf
double	rapid_time_dependent_potassium_current_Xr2_gate_alpha_xr2
double	rapid_time_dependent_potassium_current_Xr2_gate_beta_xr2
double	rapid_time_dependent_potassium_current_Xr2_gate_tau_xr2
double	rapid_time_dependent_potassium_current_Xr2_gate_xr2_inf
double	rapid_time_dependent_potassium_current_i_Kr
double	reversal_potentials_E_Ca
double	reversal_potentials_E_K
double	reversal_potentials_E_Ks
double	reversal_potentials_E_Na
double	slow_time_dependent_potassium_current_Xs_gate_alpha_xs
double	slow_time_dependent_potassium_current_Xs_gate_beta_xs
double	slow_time_dependent_potassium_current_Xs_gate_tau_xs
double	slow_time_dependent_potassium_current_Xs_gate_xs_inf
double	slow_time_dependent_potassium_current_i_Ks
double	sodium_background_current_i_b_Na
double	sodium_calcium_exchanger_current_i_NaCa
double	sodium_potassium_pump_current_i_NaK
double	transient_outward_current_i_to
double	transient_outward_current_r_gate_r_inf
double	transient_outward_current_r_gate_tau_r
double	transient_outward_current_s_gate_s_inf
double	transient_outward_current_s_gate_tau_s
Static Private Attributes
static const double	L_type_Ca_current_g_CaL = 0.0000398
static const double	calcium_background_current_g_bca = 0.000592
static const double	calcium_dynamics_Buf_c = 0.2
static const double	calcium_dynamics_Buf_sr = 10.0
static const double	calcium_dynamics_Buf_ss = 0.4
static const double	calcium_dynamics_Ca_o = 2.0
static const double	calcium_dynamics_EC = 1.5
static const double	calcium_dynamics_K_buf_c = 0.001
static const double	calcium_dynamics_K_buf_sr = 0.3
static const double	calcium_dynamics_K_buf_ss = 0.00025
static const double	calcium_dynamics_K_up = 0.00025
static const double	calcium_dynamics_V_leak = 0.00036
static const double	calcium_dynamics_V_rel = 0.102
static const double	calcium_dynamics_V_sr = 0.001094
static const double	calcium_dynamics_V_ss = 0.00005468
static const double	calcium_dynamics_V_xfer = 0.0038
static const double	calcium_dynamics_Vmax_up = 0.006375
static const double	calcium_dynamics_k1_prime = 0.15
static const double	calcium_dynamics_k2_prime = 0.045
static const double	calcium_dynamics_k3 = 0.06
static const double	calcium_dynamics_k4 = 0.005
static const double	calcium_dynamics_max_sr = 2.5
static const double	calcium_dynamics_min_sr = 1.0
static const double	calcium_pump_current_K_pCa = 0.0005
static const double	calcium_pump_current_g_pCa = 0.1238
static const double	fast_sodium_current_g_Na = 14.838
static const double	inward_rectifier_potassium_current_g_K1 = 5.405
static const double	membrane_Cm = 0.185
static const double	membrane_F = 96485.3415
static const double	membrane_R = 8314.472
static const double	membrane_T = 310.0
static const double	membrane_V_c = 0.016404
static const double	potassium_dynamics_K_o = 5.4
static const double	potassium_pump_current_g_pK = 0.0146
static const double	rapid_time_dependent_potassium_current_g_Kr = 0.153
static const double	reversal_potentials_P_kna = 0.03
static const double	slow_time_dependent_potassium_current_g_Ks = 0.392
static const double	sodium_background_current_g_bna = 0.00029
static const double	sodium_calcium_exchanger_current_K_NaCa = 1000.0
static const double	sodium_calcium_exchanger_current_K_sat = 0.1
static const double	sodium_calcium_exchanger_current_Km_Ca = 1.38
static const double	sodium_calcium_exchanger_current_Km_Nai = 87.5
static const double	sodium_calcium_exchanger_current_alpha = 2.5
static const double	sodium_calcium_exchanger_current_gamma = 0.35
static const double	sodium_dynamics_Na_o = 140.0
static const double	sodium_potassium_pump_current_K_mNa = 40.0
static const double	sodium_potassium_pump_current_K_mk = 1.0
static const double	sodium_potassium_pump_current_P_NaK = 2.724
static const double	transient_outward_current_g_to = 0.294