DiFrancescoNoble1985OdeSystem.hpp

00001 /*
00002 
00003 Copyright (C) University of Oxford, 2005-2010
00004 
00005 University of Oxford means the Chancellor, Masters and Scholars of the
00006 University of Oxford, having an administrative office at Wellington
00007 Square, Oxford OX1 2JD, UK.
00008 
00009 This file is part of Chaste.
00010 
00011 Chaste is free software: you can redistribute it and/or modify it
00012 under the terms of the GNU Lesser General Public License as published
00013 by the Free Software Foundation, either version 2.1 of the License, or
00014 (at your option) any later version.
00015 
00016 Chaste is distributed in the hope that it will be useful, but WITHOUT
00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
00018 FITNESS FOR A PARTICULAR PURPOSE.  See the GNU Lesser General Public
00019 License for more details. The offer of Chaste under the terms of the
00020 License is subject to the License being interpreted in accordance with
00021 English Law and subject to any action against the University of Oxford
00022 being under the jurisdiction of the English Courts.
00023 
00024 You should have received a copy of the GNU Lesser General Public License
00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>.
00026 
00027 */
00028 #ifndef _DIFRANCESCONOBLE1985ODESYSTEM_HPP_
00029 #define _DIFRANCESCONOBLE1985ODESYSTEM_HPP_
00030 
00031 #include "AbstractCardiacCell.hpp"
00032 #include "AbstractStimulusFunction.hpp"
00033 #include <vector>
00034 
00039 class DiFrancescoNoble1985OdeSystem : public AbstractCardiacCell
00040 {
00041 private:
00042 
00043     /* Constants for the DifrancescoNoble1985 model */
00044     static const double membrane_C; 
00045     static const double radius; 
00046     static const double length; 
00047     static const double V_e_ratio; 
00048     static const double R; 
00049     static const double T; 
00050     static const double F; 
00052     // conductances and the like
00053     static const double g_fna; 
00054     static const double g_fk; 
00055     static const double g_na_b; 
00056     static const double g_ca_b; 
00057     static const double g_na; 
00058     static const double g_k1; 
00059     static const double g_to; 
00060     static const double I_P; 
00061     static const double i_kmax; 
00062     static const double k_naca; 
00063     static const double P_si; 
00064     //concentrations
00065     static const double Nao; 
00066     static const double Cao; 
00067     static const double Kb; 
00068     static const double Kmf; 
00069     static const double Km1; 
00070     static const double Kmto; 
00071     static const double KmK; 
00072     static const double KmNa; 
00073     static const double Kmf2; 
00074     static const double KmCa; 
00075     static const double Km_Ca; 
00076     //others
00077     static const double n_naca; 
00078     static const double gamma; 
00079     static const double d_naca; 
00080     static const double rCa; 
00081     static const double tau_up; 
00082     static const double tau_rep; 
00083     static const double tau_rel; 
00084     static const double Ca_up_max; 
00085     static const double pf; 
00086     static const double Vecs; 
00089     double Vi;
00091     double Vup;
00093     double Vrel;
00095     double Ve;
00097     double Vcell;
00099     double RToNF;
00105     void VerifyStateVariables();
00106 
00107 public:
00114     DiFrancescoNoble1985OdeSystem(boost::shared_ptr<AbstractIvpOdeSolver> pSolver,
00115                                   boost::shared_ptr<AbstractStimulusFunction> pIntracellularStimulus);
00116 
00120     ~DiFrancescoNoble1985OdeSystem();
00121 
00131     void EvaluateYDerivatives(double time, const std::vector<double> &rY, std::vector<double> &rDY);
00132 
00138     double GetIIonic();
00139 
00140 };
00141 
00142 #endif // _DIFRANCESCONOBLE_HPP_