DiFrancescoNoble1985OdeSystem Class Reference

#include <DiFrancescoNoble1985OdeSystem.hpp>

Collaboration diagram for DiFrancescoNoble1985OdeSystem:

Public Member Functions
	DiFrancescoNoble1985OdeSystem (boost::shared_ptr< AbstractIvpOdeSolver > pSolver, boost::shared_ptr< AbstractStimulusFunction > pIntracellularStimulus)
	~DiFrancescoNoble1985OdeSystem ()
void	EvaluateYDerivatives (double time, const std::vector< double > &rY, std::vector< double > &rDY)
double	GetIIonic ()
Private Member Functions
void	VerifyStateVariables ()
Private Attributes
double	Vi
double	Vup
double	Vrel
double	Ve
double	Vcell
double	RToNF
Static Private Attributes
static const double	membrane_C = 75.0
static const double	radius = 0.05
static const double	length = 2
static const double	V_e_ratio = 0.1
static const double	R = 8314.472
static const double	T = 310
static const double	F = 96485.3415
static const double	g_fna = 3
static const double	g_fk = 3
static const double	g_na_b = 0.18
static const double	g_ca_b = 0.02
static const double	g_na = 750.0
static const double	g_k1 = 920
static const double	g_to = 0.28
static const double	I_P = 125
static const double	i_kmax = 180
static const double	k_naca = 0.02
static const double	P_si = 15.0
static const double	Nao = 140
static const double	Cao = 2
static const double	Kb = 4
static const double	Kmf = 45
static const double	Km1 = 210
static const double	Kmto = 10
static const double	KmK = 1
static const double	KmNa = 40
static const double	Kmf2 = 0.001
static const double	KmCa = 0.001
static const double	Km_Ca = 0.0005
static const double	n_naca = 3
static const double	gamma = 0.5
static const double	d_naca = 0.001
static const double	rCa = 2.0
static const double	tau_up = 0.025
static const double	tau_rep = 2
static const double	tau_rel = 0.05
static const double	Ca_up_max = 5
static const double	pf = 0.0007
static const double	Vecs = 0.05

Detailed Description

This class sets up the DifrancescoNoble1985 equations. In this version of the model the time is in milliseconds (unlike the paper).

Definition at line 39 of file DiFrancescoNoble1985OdeSystem.hpp.

Constructor & Destructor Documentation

DiFrancescoNoble1985OdeSystem::DiFrancescoNoble1985OdeSystem	(	boost::shared_ptr< AbstractIvpOdeSolver >	pSolver,
		boost::shared_ptr< AbstractStimulusFunction >	pIntracellularStimulus
	)

Constructor

Parameters:

	pSolver	is a pointer to the ODE solver
	pIntracellularStimulus	is a pointer to the intracellular stimulus

Definition at line 83 of file DiFrancescoNoble1985OdeSystem.cpp.

References F, AbstractCardiacCell::Init(), length, AbstractOdeSystem::mpSystemInfo, R, radius, RToNF, T, V_e_ratio, Vcell, Ve, Vecs, Vi, Vrel, and Vup.

DiFrancescoNoble1985OdeSystem::~DiFrancescoNoble1985OdeSystem ( void )

Destructor

Definition at line 105 of file DiFrancescoNoble1985OdeSystem.cpp.

Member Function Documentation

void DiFrancescoNoble1985OdeSystem::EvaluateYDerivatives	(	double	time,
		const std::vector< double > &	rY,
		std::vector< double > &	rDY
	)			`[virtual]`

Fill in a vector representing the RHS of the TenTusscher2006 system of Odes at each time step, y' = [y1' ... yn']. Some ODE solver will call this function repeatedly to solve for y = [y1 ... yn].

Parameters:

	time	the current time, in milliseconds
	rY	current values of the state variables
	rDY	to be filled in with derivatives

Fill in a vector representing the RHS of the LuoRudyIModel1991OdeSystem system of Odes at each time step, y' = [y1' ... yn']. Some ODE solver will call this function repeatedly to solve for y = [y1 ... yn].

Parameters:

	time	the current time, in milliseconds
	rY	current values of the state variables
	rDY	to be filled in with derivatives

Implements AbstractOdeSystem.

Definition at line 118 of file DiFrancescoNoble1985OdeSystem.cpp.

References Ca_up_max, Cao, d_naca, F, g_ca_b, g_fk, g_fna, g_k1, g_na, g_na_b, g_to, gamma, AbstractCardiacCell::GetStimulus(), i_kmax, I_P, k_naca, Kb, Km1, Km_Ca, KmCa, Kmf, Kmf2, KmK, KmNa, Kmto, membrane_C, AbstractCardiacCell::mSetVoltageDerivativeToZero, n_naca, Nao, P_si, pf, rCa, RToNF, tau_rel, tau_rep, tau_up, Ve, VerifyStateVariables(), Vi, Vrel, and Vup.

double DiFrancescoNoble1985OdeSystem::GetIIonic ( ) [virtual]

Returns the ionic current

Returns:: the total ionic current

Implements AbstractCardiacCell.

Definition at line 333 of file DiFrancescoNoble1985OdeSystem.cpp.

References Cao, d_naca, g_ca_b, g_fk, g_fna, g_k1, g_na, g_na_b, g_to, gamma, i_kmax, I_P, k_naca, Km1, Km_Ca, Kmf, KmK, KmNa, Kmto, AbstractOdeSystem::mStateVariables, n_naca, Nao, P_si, and RToNF.

void DiFrancescoNoble1985OdeSystem::VerifyStateVariables ( ) [private, virtual]

Range-checking on the current values of the state variables. Make sure all gating variables have are within zero and one, and all concentrations are positive

Reimplemented from AbstractCardiacCell.

Definition at line 412 of file DiFrancescoNoble1985OdeSystem.cpp.

References AbstractOdeSystem::DumpState(), and AbstractOdeSystem::rGetStateVariables().

Referenced by EvaluateYDerivatives().