TenTusscher2006OdeSystem.hpp

00001 /*
00002 
00003 Copyright (C) University of Oxford, 2005-2010
00004 
00005 University of Oxford means the Chancellor, Masters and Scholars of the
00006 University of Oxford, having an administrative office at Wellington
00007 Square, Oxford OX1 2JD, UK.
00008 
00009 This file is part of Chaste.
00010 
00011 Chaste is free software: you can redistribute it and/or modify it
00012 under the terms of the GNU Lesser General Public License as published
00013 by the Free Software Foundation, either version 2.1 of the License, or
00014 (at your option) any later version.
00015 
00016 Chaste is distributed in the hope that it will be useful, but WITHOUT
00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
00018 FITNESS FOR A PARTICULAR PURPOSE.  See the GNU Lesser General Public
00019 License for more details. The offer of Chaste under the terms of the
00020 License is subject to the License being interpreted in accordance with
00021 English Law and subject to any action against the University of Oxford
00022 being under the jurisdiction of the English Courts.
00023 
00024 You should have received a copy of the GNU Lesser General Public License
00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>.
00026 
00027 */
00028 
00029 #ifndef _TENTUSSCHER2006ODESYSTEM_HPP_
00030 #define _TENTUSSCHER2006ODESYSTEM_HPP_
00031 
00032 #include "AbstractCardiacCell.hpp"
00033 #include "AbstractStimulusFunction.hpp"
00034 #include <vector>
00035 
00039 class TenTusscher2006OdeSystem : public AbstractCardiacCell
00040 {
00041 private:
00042 
00043 
00044     double mScaleFactorGks;
00045     double mScaleFactorIto;
00046     double mScaleFactorGkr;
00048 
00049     //Constants for the TenTusscher2006 model, values for epicardial cell.
00051     static const double L_type_Ca_current_g_CaL; 
00052     static const double calcium_background_current_g_bca; 
00053     static const double calcium_dynamics_Buf_c;   
00054     static const double calcium_dynamics_Buf_sr;   
00055     static const double calcium_dynamics_Buf_ss;   
00056     static const double calcium_dynamics_Ca_o;   
00057     static const double calcium_dynamics_EC;   
00058     static const double calcium_dynamics_K_buf_c;   
00059     static const double calcium_dynamics_K_buf_sr;   
00060     static const double calcium_dynamics_K_buf_ss;   
00061     static const double calcium_dynamics_K_up;   
00062     static const double calcium_dynamics_V_leak;   
00063     static const double calcium_dynamics_V_rel;   
00064     static const double calcium_dynamics_V_sr;   
00065     static const double calcium_dynamics_V_ss;   
00066     static const double calcium_dynamics_V_xfer;   
00067     static const double calcium_dynamics_Vmax_up;   
00068     static const double calcium_dynamics_k1_prime;   
00069     static const double calcium_dynamics_k2_prime;   
00070     static const double calcium_dynamics_k3;   
00071     static const double calcium_dynamics_k4;   
00072     static const double calcium_dynamics_max_sr;   
00073     static const double calcium_dynamics_min_sr;   
00074     static const double calcium_pump_current_K_pCa;   
00075     static const double calcium_pump_current_g_pCa;   
00076     static const double fast_sodium_current_g_Na;   
00077     static const double inward_rectifier_potassium_current_g_K1;   
00078     static const double membrane_Cm;   
00079     static const double membrane_F;   
00080     static const double membrane_R;   
00081     static const double membrane_T;   
00082     static const double membrane_V_c;   
00083     static const double potassium_dynamics_K_o;   
00084     static const double potassium_pump_current_g_pK;   
00085     static const double rapid_time_dependent_potassium_current_g_Kr;   
00086     static const double reversal_potentials_P_kna;   
00087     static const double slow_time_dependent_potassium_current_g_Ks;   
00088     static const double sodium_background_current_g_bna;   
00089     static const double sodium_calcium_exchanger_current_K_NaCa;   
00090     static const double sodium_calcium_exchanger_current_K_sat;   
00091     static const double sodium_calcium_exchanger_current_Km_Ca;   
00092     static const double sodium_calcium_exchanger_current_Km_Nai;   
00093     static const double sodium_calcium_exchanger_current_alpha;   
00094     static const double sodium_calcium_exchanger_current_gamma;   
00095     static const double sodium_dynamics_Na_o;   
00096     static const double sodium_potassium_pump_current_K_mNa;   
00097     static const double sodium_potassium_pump_current_K_mk;   
00098     static const double sodium_potassium_pump_current_P_NaK;   
00099     static const double transient_outward_current_g_to;   
00104     void VerifyStateVariables();
00105 
00106 public:
00113     TenTusscher2006OdeSystem(boost::shared_ptr<AbstractIvpOdeSolver> pSolver,
00114                              boost::shared_ptr<AbstractStimulusFunction> pIntracellularStimulus);
00115 
00119     ~TenTusscher2006OdeSystem();
00120 
00130     void EvaluateYDerivatives(double time, const std::vector<double> &rY, std::vector<double> &rDY);
00131 
00137     void SetScaleFactorGks(double sfgks);
00138 
00144     void SetScaleFactorIto(double sfito);
00145 
00151     void SetScaleFactorGkr(double sfgkr);
00152 
00158     double GetIIonic();
00159 
00160 };
00161 
00162 #endif // _TENTUSSCHER2006_HPP_