#include <TenTusscher2006OdeSystem.hpp>
Inherits AbstractCardiacCell.
This class sets up the equations for the TenTusscher 2006 model. This is for an epicardial cell.
Definition at line 39 of file TenTusscher2006OdeSystem.hpp.
TenTusscher2006OdeSystem::TenTusscher2006OdeSystem | ( | boost::shared_ptr< AbstractIvpOdeSolver > | pSolver, | |
boost::shared_ptr< AbstractStimulusFunction > | pIntracellularStimulus | |||
) |
Constructor
pSolver | is a pointer to the ODE solver | |
pIntracellularStimulus | is a pointer to the intracellular stimulus |
Definition at line 91 of file TenTusscher2006OdeSystem.cpp.
References AbstractCardiacCell::Init(), AbstractOdeSystem::mpSystemInfo, mScaleFactorGkr, mScaleFactorGks, and mScaleFactorIto.
TenTusscher2006OdeSystem::~TenTusscher2006OdeSystem | ( | void | ) |
Destructor
Definition at line 107 of file TenTusscher2006OdeSystem.cpp.
void TenTusscher2006OdeSystem::EvaluateYDerivatives | ( | double | time, | |
const std::vector< double > & | rY, | |||
std::vector< double > & | rDY | |||
) | [virtual] |
Fill in a vector representing the RHS of the TenTusscher2006 system of Odes at each time step, y' = [y1' ... yn']. Some ODE solver will call this function repeatedly to solve for y = [y1 ... yn].
time | the current time, in milliseconds | |
rY | current values of the state variables | |
rDY | to be filled in with derivatives |
Implements AbstractOdeSystem.
Definition at line 124 of file TenTusscher2006OdeSystem.cpp.
References calcium_background_current_g_bca, calcium_dynamics_Buf_c, calcium_dynamics_Buf_sr, calcium_dynamics_Buf_ss, calcium_dynamics_Ca_o, calcium_dynamics_EC, calcium_dynamics_k1_prime, calcium_dynamics_k2_prime, calcium_dynamics_k3, calcium_dynamics_k4, calcium_dynamics_K_buf_c, calcium_dynamics_K_buf_sr, calcium_dynamics_K_buf_ss, calcium_dynamics_K_up, calcium_dynamics_max_sr, calcium_dynamics_min_sr, calcium_dynamics_V_leak, calcium_dynamics_V_rel, calcium_dynamics_V_sr, calcium_dynamics_V_ss, calcium_dynamics_V_xfer, calcium_dynamics_Vmax_up, calcium_pump_current_g_pCa, calcium_pump_current_K_pCa, fast_sodium_current_g_Na, AbstractCardiacCell::GetStimulus(), inward_rectifier_potassium_current_g_K1, L_type_Ca_current_g_CaL, membrane_Cm, membrane_F, membrane_R, membrane_T, membrane_V_c, mScaleFactorGkr, mScaleFactorGks, mScaleFactorIto, AbstractCardiacCell::mSetVoltageDerivativeToZero, potassium_dynamics_K_o, potassium_pump_current_g_pK, rapid_time_dependent_potassium_current_g_Kr, reversal_potentials_P_kna, slow_time_dependent_potassium_current_g_Ks, sodium_background_current_g_bna, sodium_calcium_exchanger_current_alpha, sodium_calcium_exchanger_current_gamma, sodium_calcium_exchanger_current_K_NaCa, sodium_calcium_exchanger_current_K_sat, sodium_calcium_exchanger_current_Km_Ca, sodium_calcium_exchanger_current_Km_Nai, sodium_dynamics_Na_o, sodium_potassium_pump_current_K_mk, sodium_potassium_pump_current_K_mNa, sodium_potassium_pump_current_P_NaK, transient_outward_current_g_to, and VerifyStateVariables().
double TenTusscher2006OdeSystem::GetIIonic | ( | ) | [virtual] |
Returns the ionic current
Implements AbstractCardiacCell.
Definition at line 301 of file TenTusscher2006OdeSystem.cpp.
References calcium_background_current_g_bca, calcium_dynamics_Ca_o, calcium_pump_current_g_pCa, calcium_pump_current_K_pCa, fast_sodium_current_g_Na, inward_rectifier_potassium_current_g_K1, L_type_Ca_current_g_CaL, membrane_F, membrane_R, membrane_T, mScaleFactorGkr, mScaleFactorGks, mScaleFactorIto, AbstractOdeSystem::mStateVariables, potassium_dynamics_K_o, potassium_pump_current_g_pK, rapid_time_dependent_potassium_current_g_Kr, reversal_potentials_P_kna, slow_time_dependent_potassium_current_g_Ks, sodium_background_current_g_bna, sodium_calcium_exchanger_current_alpha, sodium_calcium_exchanger_current_gamma, sodium_calcium_exchanger_current_K_NaCa, sodium_calcium_exchanger_current_K_sat, sodium_calcium_exchanger_current_Km_Ca, sodium_calcium_exchanger_current_Km_Nai, sodium_dynamics_Na_o, sodium_potassium_pump_current_K_mk, sodium_potassium_pump_current_K_mNa, sodium_potassium_pump_current_P_NaK, and transient_outward_current_g_to.
void TenTusscher2006OdeSystem::SetScaleFactorGkr | ( | double | sfgkr | ) |
Set the scale factor for Gks in order to differentiate epi M and endo cells
sfgkr | is the scale factor for Gkr conductance |
Definition at line 119 of file TenTusscher2006OdeSystem.cpp.
References mScaleFactorGkr.
Referenced by HeartConfigRelatedCellFactory< SPACE_DIM >::CreateCellWithIntracellularStimulus().
void TenTusscher2006OdeSystem::SetScaleFactorGks | ( | double | sfgks | ) |
Set the scale factor for Gks in order to differentiate epi M and endo cells
sfgks | is the scale factor for Gks conductance |
Definition at line 111 of file TenTusscher2006OdeSystem.cpp.
References mScaleFactorGks.
Referenced by HeartConfigRelatedCellFactory< SPACE_DIM >::CreateCellWithIntracellularStimulus().
void TenTusscher2006OdeSystem::SetScaleFactorIto | ( | double | sfito | ) |
Set the scale factor for Gks in order to differentiate epi M and endo cells
sfito | is the scale factor for Ito current |
Definition at line 115 of file TenTusscher2006OdeSystem.cpp.
References mScaleFactorIto.
Referenced by HeartConfigRelatedCellFactory< SPACE_DIM >::CreateCellWithIntracellularStimulus().
void TenTusscher2006OdeSystem::VerifyStateVariables | ( | ) | [private, virtual] |
This private method will check that gates are within 0 and 1 and concentrations are positive
Reimplemented from AbstractCardiacCell.
Definition at line 370 of file TenTusscher2006OdeSystem.cpp.
References AbstractOdeSystem::DumpState(), and AbstractOdeSystem::rGetStateVariables().
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_background_current_g_bca = 0.000592 [static, private] |
nanoS_per_picoF
Definition at line 52 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::calcium_dynamics_Buf_c = 0.2 [static, private] |
millimolar
Definition at line 53 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_Buf_sr = 10.0 [static, private] |
millimolar
Definition at line 54 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_Buf_ss = 0.4 [static, private] |
millimolar
Definition at line 55 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_Ca_o = 2.0 [static, private] |
millimolar
Definition at line 56 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::calcium_dynamics_EC = 1.5 [static, private] |
millimolar
Definition at line 57 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_k1_prime = 0.15 [static, private] |
per_millimolar2_per_millisecond
Definition at line 68 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_k2_prime = 0.045 [static, private] |
per_millimolar_per_millisecond
Definition at line 69 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_k3 = 0.06 [static, private] |
per_millisecond
Definition at line 70 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_k4 = 0.005 [static, private] |
per_millisecond
Definition at line 71 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_K_buf_c = 0.001 [static, private] |
millimolar
Definition at line 58 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_K_buf_sr = 0.3 [static, private] |
millimolar
Definition at line 59 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_K_buf_ss = 0.00025 [static, private] |
millimolar
Definition at line 60 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_K_up = 0.00025 [static, private] |
millimolar
Definition at line 61 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_max_sr = 2.5 [static, private] |
dimensionless
Definition at line 72 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_min_sr = 1.0 [static, private] |
dimensionless
Definition at line 73 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_V_leak = 0.00036 [static, private] |
millimolar_per_millisecond
Definition at line 62 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_V_rel = 0.102 [static, private] |
millimolar_per_millisecond
Definition at line 63 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_V_sr = 0.001094 [static, private] |
micrometre3
Definition at line 64 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_V_ss = 0.00005468 [static, private] |
micrometre3
Definition at line 65 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_V_xfer = 0.0038 [static, private] |
millimolar_per_millisecond
Definition at line 66 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_dynamics_Vmax_up = 0.006375 [static, private] |
millimolar_per_millisecond
Definition at line 67 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::calcium_pump_current_g_pCa = 0.1238 [static, private] |
nanoS_per_picoF
Definition at line 75 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::calcium_pump_current_K_pCa = 0.0005 [static, private] |
millimolar
Definition at line 74 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::fast_sodium_current_g_Na = 14.838 [static, private] |
nanoS_per_picoF
Definition at line 76 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::inward_rectifier_potassium_current_g_K1 = 5.405 [static, private] |
nanoS_per_picoF
Definition at line 77 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::L_type_Ca_current_g_CaL = 0.0000398 [static, private] |
nanoS_per_picoF
Definition at line 51 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::membrane_Cm = 0.185 [static, private] |
microF_per_cm2
Definition at line 78 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
const double TenTusscher2006OdeSystem::membrane_F = 96485.3415 [static, private] |
coulomb_per_millimole
Definition at line 79 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::membrane_R = 8314.472 [static, private] |
joule_per_mole_kelvin
Definition at line 80 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::membrane_T = 310.0 [static, private] |
kelvin
Definition at line 81 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::membrane_V_c = 0.016404 [static, private] |
micrometre3
Definition at line 82 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives().
Scale factor for Gkr
Definition at line 46 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), GetIIonic(), SetScaleFactorGkr(), and TenTusscher2006OdeSystem().
Scale factor for Gks
Definition at line 44 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), GetIIonic(), SetScaleFactorGks(), and TenTusscher2006OdeSystem().
Scale factor for Gto
Definition at line 45 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), GetIIonic(), SetScaleFactorIto(), and TenTusscher2006OdeSystem().
const double TenTusscher2006OdeSystem::potassium_dynamics_K_o = 5.4 [static, private] |
millimolar
Definition at line 83 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::potassium_pump_current_g_pK = 0.0146 [static, private] |
nanoS_per_picoF
Definition at line 84 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::rapid_time_dependent_potassium_current_g_Kr = 0.153 [static, private] |
nanoS_per_picoF
Definition at line 85 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::reversal_potentials_P_kna = 0.03 [static, private] |
nanoA_per_millimolar
Definition at line 86 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::slow_time_dependent_potassium_current_g_Ks = 0.392 [static, private] |
nanoS_per_picoF
Definition at line 87 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::sodium_background_current_g_bna = 0.00029 [static, private] |
nanoS_per_picoF
Definition at line 88 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::sodium_calcium_exchanger_current_alpha = 2.5 [static, private] |
dimensionless
Definition at line 93 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::sodium_calcium_exchanger_current_gamma = 0.35 [static, private] |
dimensionless
Definition at line 94 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::sodium_calcium_exchanger_current_K_NaCa = 1000.0 [static, private] |
picoA_per_picoF
Definition at line 89 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::sodium_calcium_exchanger_current_K_sat = 0.1 [static, private] |
dimensionless
Definition at line 90 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::sodium_calcium_exchanger_current_Km_Ca = 1.38 [static, private] |
millimolar
Definition at line 91 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::sodium_calcium_exchanger_current_Km_Nai = 87.5 [static, private] |
millimolar
Definition at line 92 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::sodium_dynamics_Na_o = 140.0 [static, private] |
millimolar
Definition at line 95 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::sodium_potassium_pump_current_K_mk = 1.0 [static, private] |
millimolar
Definition at line 97 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::sodium_potassium_pump_current_K_mNa = 40.0 [static, private] |
millimolar
Definition at line 96 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::sodium_potassium_pump_current_P_NaK = 2.724 [static, private] |
picoA_per_picoF
Definition at line 98 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().
const double TenTusscher2006OdeSystem::transient_outward_current_g_to = 0.294 [static, private] |
nanoS_per_picoF
Definition at line 99 of file TenTusscher2006OdeSystem.hpp.
Referenced by EvaluateYDerivatives(), and GetIIonic().