00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2010 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 #ifndef TYSONNOVAKCELLCYCLEMODEL_HPP_ 00029 #define TYSONNOVAKCELLCYCLEMODEL_HPP_ 00030 00031 #include "ChasteSerialization.hpp" 00032 00033 #include <iostream> 00034 00035 #include "AbstractOdeBasedCellCycleModelWithStoppingEvent.hpp" 00036 #include "TysonNovak2001OdeSystem.hpp" 00037 #include "BackwardEulerIvpOdeSolver.hpp" 00038 #include "CvodeAdaptor.hpp" 00039 #include "Exception.hpp" 00040 00050 class TysonNovakCellCycleModel : public AbstractOdeBasedCellCycleModelWithStoppingEvent 00051 { 00052 private: 00053 00054 friend class TestOdeBasedCellCycleModels; 00055 00056 #ifdef CHASTE_CVODE 00057 00058 static CvodeAdaptor msSolver; 00059 #else 00060 00061 static BackwardEulerIvpOdeSolver msSolver; 00062 #endif //CHASTE_CVODE 00063 00065 friend class boost::serialization::access; 00072 template<class Archive> 00073 void serialize(Archive & archive, const unsigned int version) 00074 { 00075 archive & boost::serialization::base_object<AbstractOdeBasedCellCycleModelWithStoppingEvent>(*this); 00076 } 00077 00078 public: 00079 00083 TysonNovakCellCycleModel(); 00084 00092 TysonNovakCellCycleModel(const TysonNovakCellCycleModel& rOtherModel); 00093 00098 void ResetForDivision(); 00099 00104 AbstractCellCycleModel* CreateCellCycleModel(); 00105 00112 bool SolveOdeToTime(double currentTime); 00113 00119 double GetOdeStopTime(); 00120 00124 double GetSDuration(); 00125 00129 double GetG2Duration(); 00130 00134 double GetMDuration(); 00135 00139 void InitialiseDaughterCell(); 00140 00144 double GetAverageTransitCellCycleTime(); 00145 00149 double GetAverageStemCellCycleTime(); 00150 00154 virtual bool CanCellTerminallyDifferentiate(); 00155 }; 00156 00157 00158 #include "SerializationExportWrapper.hpp" 00159 // Declare identifier for the serializer 00160 CHASTE_CLASS_EXPORT(TysonNovakCellCycleModel) 00161 00162 00163 #endif /*TYSONNOVAKCELLCYCLEMODEL_HPP_*/