00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2010 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 #include "AbstractCryptStatistics.hpp" 00029 #include "CellPropertyRegistry.hpp" 00030 00031 AbstractCryptStatistics::AbstractCryptStatistics(MeshBasedCellPopulation<2>& rCrypt) 00032 : mrCrypt(rCrypt) 00033 { 00034 } 00035 00036 AbstractCryptStatistics::~AbstractCryptStatistics() 00037 { 00038 } 00039 00040 void AbstractCryptStatistics::LabelSPhaseCells() 00041 { 00042 for (AbstractCellPopulation<2>::Iterator cell_iter = mrCrypt.Begin(); 00043 cell_iter != mrCrypt.End(); 00044 ++cell_iter) 00045 { 00046 if (cell_iter->GetCellCycleModel()->GetCurrentCellCyclePhase()== S_PHASE) 00047 { 00048 // This should only be done for wild type cells (at the moment anyway) 00049 assert(cell_iter->GetMutationState()->IsType<WildTypeCellMutationState>()); 00050 00051 // Label this cell 00052 if (!cell_iter->HasCellProperty<CellLabel>()); 00053 { 00054 cell_iter->AddCellProperty(CellPropertyRegistry::Instance()->Get<CellLabel>()); 00055 } 00056 } 00057 } 00058 } 00059 00060 void AbstractCryptStatistics::LabelAllCellsAsHealthy() 00061 { 00062 for (AbstractCellPopulation<2>::Iterator cell_iter = mrCrypt.Begin(); 00063 cell_iter != mrCrypt.End(); 00064 ++cell_iter) 00065 { 00066 cell_iter->SetMutationState(CellPropertyRegistry::Instance()->Get<WildTypeCellMutationState>()); 00067 cell_iter->RemoveCellProperty<CellLabel>(); 00068 } 00069 } 00070 00071 std::vector<bool> AbstractCryptStatistics::AreCryptSectionCellsLabelled(std::vector<CellPtr>& rCryptSection) 00072 { 00073 std::vector<bool> crypt_section_labelled(rCryptSection.size()); 00074 00075 for (unsigned vector_index=0; vector_index<rCryptSection.size(); vector_index++) 00076 { 00077 if (rCryptSection[vector_index]->HasCellProperty<CellLabel>()) 00078 { 00079 crypt_section_labelled[vector_index] = true; 00080 } 00081 else 00082 { 00083 crypt_section_labelled[vector_index] = false; 00084 } 00085 } 00086 00087 return crypt_section_labelled; 00088 }