00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2010 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 #ifndef SIMPLEWNTCELLCYCLEMODEL_HPP_ 00029 #define SIMPLEWNTCELLCYCLEMODEL_HPP_ 00030 00031 #include "AbstractSimpleCellCycleModel.hpp" 00032 #include "RandomNumberGenerator.hpp" 00033 #include "WntConcentration.hpp" 00034 00035 // Needed here to avoid serialization errors 00036 #include "WildTypeCellMutationState.hpp" 00037 #include "CellLabel.hpp" 00038 #include "ApcOneHitCellMutationState.hpp" 00039 #include "ApcTwoHitCellMutationState.hpp" 00040 #include "BetaCateninOneHitCellMutationState.hpp" 00041 00042 00046 class SimpleWntCellCycleModel : public AbstractSimpleCellCycleModel 00047 { 00048 private: 00049 00051 friend class boost::serialization::access; 00058 template<class Archive> 00059 void serialize(Archive & archive, const unsigned int version) 00060 { 00061 archive & boost::serialization::base_object<AbstractSimpleCellCycleModel>(*this); 00062 00063 RandomNumberGenerator* p_gen = RandomNumberGenerator::Instance(); 00064 archive & *p_gen; 00065 00066 archive & mUseCellProliferativeTypeDependentG1Duration; 00067 archive & mWntStemThreshold; 00068 archive & mWntTransitThreshold; 00069 archive & mWntLabelledThreshold; 00070 } 00071 00076 bool mUseCellProliferativeTypeDependentG1Duration; 00077 00081 double mWntStemThreshold; 00082 00086 double mWntTransitThreshold; 00087 00091 double mWntLabelledThreshold; 00092 00093 protected: 00094 00098 double GetWntLevel(); 00099 00104 WntConcentrationType GetWntType(); 00105 00115 void SetG1Duration(); 00116 00117 public: 00118 00123 SimpleWntCellCycleModel(); 00124 00128 virtual void UpdateCellCyclePhase(); 00129 00133 virtual void InitialiseDaughterCell(); 00134 00139 virtual AbstractCellCycleModel* CreateCellCycleModel(); 00140 00145 void SetUseCellProliferativeTypeDependentG1Duration(bool useCellProliferativeTypeDependentG1Duration=true); 00146 00150 virtual bool CanCellTerminallyDifferentiate(); 00151 00155 double GetWntStemThreshold(); 00156 00162 void SetWntStemThreshold(double wntStemThreshold); 00163 00167 double GetWntTransitThreshold(); 00168 00174 void SetWntTransitThreshold(double wntTransitThreshold); 00175 00179 double GetWntLabelledThreshold(); 00180 00186 void SetWntLabelledThreshold(double wntLabelledThreshold); 00187 }; 00188 00189 #include "SerializationExportWrapper.hpp" 00190 // Declare identifier for the serializer 00191 CHASTE_CLASS_EXPORT(SimpleWntCellCycleModel) 00192 00193 #endif /*SIMPLEWNTCELLCYCLEMODEL_HPP_*/