AbstractPhaseBasedCellCycleModel.hpp

/*

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*/

#ifndef ABSTRACTPHASEBASEDCELLCYCLEMODEL_HPP_
#define ABSTRACTPHASEBASEDCELLCYCLEMODEL_HPP_

#include "ChasteSerialization.hpp"
#include "ClassIsAbstract.hpp"

#include <boost/serialization/base_object.hpp>

#include <vector>

#include "AbstractCellCycleModel.hpp"
#include "CellCyclePhases.hpp"
#include "SimulationTime.hpp"


class AbstractPhaseBasedCellCycleModel : public AbstractCellCycleModel
{
private:

    friend class boost::serialization::access;
    template<class Archive>
    void serialize(Archive & archive, const unsigned int version)
    {
        archive & boost::serialization::base_object<AbstractCellCycleModel>(*this);
        archive & mCurrentCellCyclePhase;
        archive & mG1Duration;
        archive & mMinimumGapDuration;
        archive & mStemCellG1Duration;
        archive & mTransitCellG1Duration;
        archive & mSDuration;
        archive & mG2Duration;
        archive & mMDuration;
    }

protected:

    CellCyclePhase mCurrentCellCyclePhase;

    double mG1Duration;

    double mMinimumGapDuration;

    double mStemCellG1Duration;

    double mTransitCellG1Duration;

    double mSDuration;

    double mG2Duration;

    double mMDuration;

    AbstractPhaseBasedCellCycleModel(const AbstractPhaseBasedCellCycleModel& rModel);

public:

    AbstractPhaseBasedCellCycleModel();

    virtual ~AbstractPhaseBasedCellCycleModel();

    virtual bool ReadyToDivide();

    virtual void ResetForDivision();

    virtual void UpdateCellCyclePhase()=0;

    CellCyclePhase GetCurrentCellCyclePhase() const;

    virtual double GetG1Duration() const;

    double GetStemCellG1Duration() const;

    double GetTransitCellG1Duration() const;

    double GetSG2MDuration() const;

    virtual double GetSDuration() const;

    virtual double GetG2Duration() const;

    virtual double GetMDuration() const;

    virtual void SetStemCellG1Duration(double stemCellG1Duration);

    virtual void SetTransitCellG1Duration(double transitCellG1Duration);

    void SetSDuration(double sDuration);

    void SetG2Duration(double g2Duration);

    void SetMDuration(double mDuration);

    virtual double GetAverageTransitCellCycleTime();

    virtual double GetAverageStemCellCycleTime();

    double GetMinimumGapDuration() const;

    void SetMinimumGapDuration(double minimumGapDuration);

    virtual void OutputCellCycleModelParameters(out_stream& rParamsFile)=0;
};

CLASS_IS_ABSTRACT(AbstractPhaseBasedCellCycleModel)

#endif /*ABSTRACTPHASEBASEDCELLCYCLEMODEL_HPP_*/