AbstractVanLeeuwen2009WntSwatCellCycleModel.hpp

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*/

#ifndef ABSTRACTVANLEEUWEN2009WNTSWATCELLCYCLEMODEL_HPP_
#define ABSTRACTVANLEEUWEN2009WNTSWATCELLCYCLEMODEL_HPP_

#include "ChasteSerialization.hpp"
#include "ClassIsAbstract.hpp"
#include <boost/serialization/base_object.hpp>

#include <cfloat>

#include "AbstractOdeSystem.hpp"
#include "AbstractWntOdeBasedCellCycleModel.hpp"
#include "VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp"
#include "AbstractCellMutationState.hpp"

class AbstractVanLeeuwen2009WntSwatCellCycleModel : public AbstractWntOdeBasedCellCycleModel
{
private:

    friend class boost::serialization::access;
    template<class Archive>
    void serialize(Archive & archive, const unsigned int version)
    {
        archive & boost::serialization::base_object<AbstractWntOdeBasedCellCycleModel>(*this);
    }

    void ChangeCellProliferativeTypeDueToCurrentBetaCateninLevel();

    void AdjustOdeParameters(double currentTime);

protected:

    AbstractVanLeeuwen2009WntSwatCellCycleModel(const AbstractVanLeeuwen2009WntSwatCellCycleModel& rModel);

public:

    AbstractVanLeeuwen2009WntSwatCellCycleModel(boost::shared_ptr<AbstractCellCycleModelOdeSolver> pOdeSolver = boost::shared_ptr<AbstractCellCycleModelOdeSolver>());

    void Initialise();

    double GetMembraneBoundBetaCateninLevel();

    double GetCytoplasmicBetaCateninLevel();

    double GetNuclearBetaCateninLevel();

    virtual void InitialiseOdeSystem(double wntConcentration, boost::shared_ptr<AbstractCellMutationState> pMutationState)=0;

    virtual void OutputCellCycleModelParameters(out_stream& rParamsFile);
};

CLASS_IS_ABSTRACT(AbstractVanLeeuwen2009WntSwatCellCycleModel)

#endif /*ABSTRACTVANLEEUWEN2009WNTSWATCELLCYCLEMODEL_HPP_*/