CorriasBuistSMCModified.hpp

/*

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*/

#ifndef CorriasBuistSMCModified_HPP_
#define CorriasBuistSMCModified_HPP_


#include "ChasteSerialization.hpp"
#include <boost/serialization/base_object.hpp>
#include "AbstractCardiacCell.hpp"
#include "AbstractStimulusFunction.hpp"
class CorriasBuistSMCModified : public AbstractCardiacCell
{
    friend class boost::serialization::access;
    template<class Archive>
    void serialize(Archive & archive, const unsigned int version)
    {
        archive & boost::serialization::base_object<AbstractCardiacCell >(*this);
    }

private:

    double mScaleFactorCarbonMonoxide;

    bool mFakeIccStimulusPresent;

    double Cm;
    double Asurf_in_cm_square;
    double Asurf;
    double VolCell;
    double hCa;
    double sCa;
    /* concentrations */
    double Ki;       
    double Nai;        
    double ACh;       
    double CaiRest;     
    /* maximum conductances*/
    double gLVA_max;                  // (0.18 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
    double gCaL_max;                  // (65.0 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
    double gBK_max;                  // (45.7 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
    double gKb_max;                   // (0.0144 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
    double gKA_max;                   // (9.0  nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
    double gKr_max;                   // (35.0 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
    double gNa_max;                    // (3.0  nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
    double gnsCC_max;                 // (50.0 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
    double gcouple;           // 1.3 nS * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
    double JCaExt_max;     
    /* Temperature corrections */
    double Q10Ca;         
    double Q10K;          //1.365
    double Q10Na;        
    double Texp;       
    double T_correct_Ca ;
    double T_correct_K ;  
    double T_correct_Na;
    double T_correct_gBK;   // (nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2

    /* Nernst potentials */
    double EK;                  
    double ENa ;               
    double EnsCC;                          
    double Ca_o;         
    double K_o;          
    double Na_o;         
    /* Nernst parameters */
    double R;    
    double T;       
    double F;     
    double FoRT;     
    double RToF;    
public:

    CorriasBuistSMCModified(boost::shared_ptr<AbstractIvpOdeSolver> pSolver, boost::shared_ptr<AbstractStimulusFunction> pIntracellularStimulus);

    ~CorriasBuistSMCModified();

    void VerifyStateVariables();

    double GetIIonic(const std::vector<double>* pStateVariables=NULL);

    void EvaluateYDerivatives(double time, const std::vector<double>& rY, std::vector<double>& rDY);


    void SetFakeIccStimulusPresent(bool present);

    bool GetFakeIccStimulusPresent();

    double SetCarbonMonoxideScaleFactor();

    void SetCarbonMonoxideScaleFactor(double scaleFactor);

    double GetCarbonMonoxideScaleFactor();
};

// Needs to be included last
#include "SerializationExportWrapper.hpp"
CHASTE_CLASS_EXPORT(CorriasBuistSMCModified)

namespace boost
{
    namespace serialization
    {
        template<class Archive>
        inline void save_construct_data(
            Archive & ar, const CorriasBuistSMCModified * t, const unsigned int fileVersion)
        {
            const boost::shared_ptr<AbstractIvpOdeSolver> p_solver = t->GetSolver();
            const boost::shared_ptr<AbstractStimulusFunction> p_stimulus = t->GetStimulusFunction();
            ar << p_solver;
            ar << p_stimulus;
        }

        template<class Archive>
        inline void load_construct_data(
            Archive & ar, CorriasBuistSMCModified * t, const unsigned int fileVersion)
        {
            boost::shared_ptr<AbstractIvpOdeSolver> p_solver;
            boost::shared_ptr<AbstractStimulusFunction> p_stimulus;
            ar >> p_solver;
            ar >> p_stimulus;
            ::new(t)CorriasBuistSMCModified(p_solver, p_stimulus);
        }
    }
}

#endif // CorriasBuistSMCModified_HPP_