AbstractWntOdeBasedCellCycleModel.hpp

/*

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*/

#ifndef ABSTRACTWNTODEBASEDCELLCYCLEMODEL_HPP_
#define ABSTRACTWNTODEBASEDCELLCYCLEMODEL_HPP_

#include "ChasteSerialization.hpp"
#include "ClassIsAbstract.hpp"
#include <boost/serialization/base_object.hpp>

#include "AbstractOdeBasedPhaseBasedCellCycleModel.hpp"
#include "WntConcentration.hpp"

class AbstractWntOdeBasedCellCycleModel : public AbstractOdeBasedPhaseBasedCellCycleModel
{
private:

    friend class boost::serialization::access;
    template<class Archive>
    void serialize(Archive & archive, const unsigned int version)
    {
        archive & boost::serialization::base_object<AbstractOdeBasedPhaseBasedCellCycleModel>(*this);
    }

protected:

    double GetWntLevel() const;

    void UpdateCellCyclePhase();

    AbstractWntOdeBasedCellCycleModel(const AbstractWntOdeBasedCellCycleModel& rModel);

public:

    AbstractWntOdeBasedCellCycleModel(boost::shared_ptr<AbstractCellCycleModelOdeSolver> pOdeSolver = boost::shared_ptr<AbstractCellCycleModelOdeSolver>());

    virtual ~AbstractWntOdeBasedCellCycleModel();

    void ResetForDivision();

    void UpdateCellProliferativeType();

    virtual void ChangeCellProliferativeTypeDueToCurrentBetaCateninLevel()=0;

    double GetAverageTransitCellCycleTime();

    double GetAverageStemCellCycleTime();

    virtual bool CanCellTerminallyDifferentiate();

    virtual void OutputCellCycleModelParameters(out_stream& rParamsFile);
};

CLASS_IS_ABSTRACT(AbstractWntOdeBasedCellCycleModel)

#endif /*ABSTRACTWNTODEBASEDCELLCYCLEMODEL_HPP_*/