StochasticOxygenBasedCellCycleModel.cpp

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*/

#include "StochasticOxygenBasedCellCycleModel.hpp"

StochasticOxygenBasedCellCycleModel::StochasticOxygenBasedCellCycleModel()
    : SimpleOxygenBasedCellCycleModel()
{
}

StochasticOxygenBasedCellCycleModel::StochasticOxygenBasedCellCycleModel(const StochasticOxygenBasedCellCycleModel& rModel)
   : SimpleOxygenBasedCellCycleModel(rModel),
     mStochasticG2Duration(rModel.mStochasticG2Duration)
{
    /*
     * Initialize only those member variables defined in this class.
     *
     * The member variables mCurrentHypoxicDuration, mCurrentHypoxiaOnsetTime,
     * mHypoxicConcentration, mQuiescentConcentration and mCriticalHypoxicDuration
     * are initialized in the SimpleOxygenBasedCellCycleModel constructor.
     *
     * The member variables mCurrentCellCyclePhase, mG1Duration,
     * mMinimumGapDuration, mStemCellG1Duration, mTransitCellG1Duration,
     * mSDuration, mG2Duration and mMDuration are initialized in the
     * AbstractPhaseBasedCellCycleModel constructor.
     *
     * The member variables mBirthTime, mReadyToDivide and mDimension
     * are initialized in the AbstractCellCycleModel constructor.
     *
     * Note that mG1Duration and mStochasticG2Duration are (re)set as
     * soon as InitialiseDaughterCell() is called on the new cell-cycle model.
     */
}

void StochasticOxygenBasedCellCycleModel::GenerateStochasticG2Duration()
{
    RandomNumberGenerator* p_gen = RandomNumberGenerator::Instance();

    double mean = AbstractPhaseBasedCellCycleModel::GetG2Duration();
    double standard_deviation = 1.0;

    mStochasticG2Duration = p_gen->NormalRandomDeviate(mean, standard_deviation);

    // Check that the normal random deviate has not returned a small or negative G2 duration
    if (mStochasticG2Duration < mMinimumGapDuration)
    {
        mStochasticG2Duration = mMinimumGapDuration;
    }
}

void StochasticOxygenBasedCellCycleModel::InitialiseDaughterCell()
{
    SimpleOxygenBasedCellCycleModel::InitialiseDaughterCell();
    GenerateStochasticG2Duration();
}

void StochasticOxygenBasedCellCycleModel::Initialise()
{
    AbstractSimplePhaseBasedCellCycleModel::Initialise();
    GenerateStochasticG2Duration();
}

void StochasticOxygenBasedCellCycleModel::ResetForDivision()
{
    SimpleOxygenBasedCellCycleModel::ResetForDivision();
    GenerateStochasticG2Duration();
}

double StochasticOxygenBasedCellCycleModel::GetG2Duration() const
{
    return mStochasticG2Duration;
}

AbstractCellCycleModel* StochasticOxygenBasedCellCycleModel::CreateCellCycleModel()
{
    return new StochasticOxygenBasedCellCycleModel(*this);
}

void StochasticOxygenBasedCellCycleModel::OutputCellCycleModelParameters(out_stream& rParamsFile)
{
    // No new parameters to output, so just call method on direct parent class
    SimpleOxygenBasedCellCycleModel::OutputCellCycleModelParameters(rParamsFile);
}

// Serialization for Boost >= 1.36
#include "SerializationExportWrapperForCpp.hpp"
CHASTE_CLASS_EXPORT(StochasticOxygenBasedCellCycleModel)