00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2011 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 00029 #include "AbstractSimpleCellCycleModel.hpp" 00030 #include "Exception.hpp" 00031 00032 AbstractSimpleCellCycleModel::AbstractSimpleCellCycleModel() 00033 { 00034 } 00035 00036 AbstractSimpleCellCycleModel::~AbstractSimpleCellCycleModel() 00037 { 00038 } 00039 00040 void AbstractSimpleCellCycleModel::Initialise() 00041 { 00042 SetG1Duration(); 00043 } 00044 00045 void AbstractSimpleCellCycleModel::InitialiseDaughterCell() 00046 { 00047 AbstractCellCycleModel::InitialiseDaughterCell(); 00048 SetG1Duration(); 00049 } 00050 00051 void AbstractSimpleCellCycleModel::SetG1Duration() 00052 { 00053 assert(mpCell != NULL); 00054 00055 switch (mCellProliferativeType) 00056 { 00057 case STEM: 00058 mG1Duration = GetStemCellG1Duration(); 00059 break; 00060 case TRANSIT: 00061 mG1Duration = GetTransitCellG1Duration(); 00062 break; 00063 case DIFFERENTIATED: 00064 mG1Duration = DBL_MAX; 00065 break; 00066 default: 00067 NEVER_REACHED; 00068 } 00069 } 00070 00071 void AbstractSimpleCellCycleModel::ResetForDivision() 00072 { 00073 AbstractCellCycleModel::ResetForDivision(); 00074 mBirthTime = SimulationTime::Instance()->GetTime(); 00075 SetG1Duration(); 00076 } 00077 00078 void AbstractSimpleCellCycleModel::UpdateCellCyclePhase() 00079 { 00080 double time_since_birth = GetAge(); 00081 assert(time_since_birth >= 0); 00082 00083 if (mCellProliferativeType == DIFFERENTIATED) 00084 { 00085 mCurrentCellCyclePhase = G_ZERO_PHASE; 00086 } 00087 else if (time_since_birth < GetMDuration()) 00088 { 00089 mCurrentCellCyclePhase = M_PHASE; 00090 } 00091 else if (time_since_birth < GetMDuration() + mG1Duration) 00092 { 00093 mCurrentCellCyclePhase = G_ONE_PHASE; 00094 } 00095 else if (time_since_birth < GetMDuration() + mG1Duration + GetSDuration()) 00096 { 00097 mCurrentCellCyclePhase = S_PHASE; 00098 } 00099 else if (time_since_birth < GetMDuration() + mG1Duration + GetSDuration() + GetG2Duration()) 00100 { 00101 mCurrentCellCyclePhase = G_TWO_PHASE; 00102 } 00103 } 00104 00105 void AbstractSimpleCellCycleModel::OutputCellCycleModelParameters(out_stream& rParamsFile) 00106 { 00107 // No new parameters to output 00108 00109 // Call method on direct parent class 00110 AbstractCellCycleModel::OutputCellCycleModelParameters(rParamsFile); 00111 }