SimpleWntCellCycleModel.hpp

/*

Copyright (C) University of Oxford, 2005-2011

University of Oxford means the Chancellor, Masters and Scholars of the
University of Oxford, having an administrative office at Wellington
Square, Oxford OX1 2JD, UK.

This file is part of Chaste.

Chaste is free software: you can redistribute it and/or modify it
under the terms of the GNU Lesser General Public License as published
by the Free Software Foundation, either version 2.1 of the License, or
(at your option) any later version.

Chaste is distributed in the hope that it will be useful, but WITHOUT
ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
FITNESS FOR A PARTICULAR PURPOSE.  See the GNU Lesser General Public
License for more details. The offer of Chaste under the terms of the
License is subject to the License being interpreted in accordance with
English Law and subject to any action against the University of Oxford
being under the jurisdiction of the English Courts.

You should have received a copy of the GNU Lesser General Public License
along with Chaste. If not, see <http://www.gnu.org/licenses/>.

*/

#ifndef SIMPLEWNTCELLCYCLEMODEL_HPP_
#define SIMPLEWNTCELLCYCLEMODEL_HPP_

#include "AbstractSimpleCellCycleModel.hpp"
#include "RandomNumberGenerator.hpp"
#include "WntConcentration.hpp"

// Needed here to avoid serialization errors
#include "WildTypeCellMutationState.hpp"
#include "CellLabel.hpp"
#include "ApcOneHitCellMutationState.hpp"
#include "ApcTwoHitCellMutationState.hpp"
#include "BetaCateninOneHitCellMutationState.hpp"


class SimpleWntCellCycleModel : public AbstractSimpleCellCycleModel
{
private:

    friend class boost::serialization::access;
    template<class Archive>
    void serialize(Archive & archive, const unsigned int version)
    {
        archive & boost::serialization::base_object<AbstractSimpleCellCycleModel>(*this);

        RandomNumberGenerator* p_gen = RandomNumberGenerator::Instance();
        archive & *p_gen;

        archive & mUseCellProliferativeTypeDependentG1Duration;
        archive & mWntStemThreshold;
        archive & mWntTransitThreshold;
        archive & mWntLabelledThreshold;
    }

protected:

    bool mUseCellProliferativeTypeDependentG1Duration;

    double mWntStemThreshold;

    double mWntTransitThreshold;

    double mWntLabelledThreshold;

    double GetWntLevel();

    WntConcentrationType GetWntType();

    void SetG1Duration();

public:

    SimpleWntCellCycleModel();

    virtual void UpdateCellCyclePhase();

    virtual void InitialiseDaughterCell();

    virtual AbstractCellCycleModel* CreateCellCycleModel();

    void SetUseCellProliferativeTypeDependentG1Duration(bool useCellProliferativeTypeDependentG1Duration=true);

    virtual bool CanCellTerminallyDifferentiate();

    double GetWntStemThreshold();

    void SetWntStemThreshold(double wntStemThreshold);

    double GetWntTransitThreshold();

    void SetWntTransitThreshold(double wntTransitThreshold);

    double GetWntLabelledThreshold();

    void SetWntLabelledThreshold(double wntLabelledThreshold);

    virtual void OutputCellCycleModelParameters(out_stream& rParamsFile);
};

#include "SerializationExportWrapper.hpp"
// Declare identifier for the serializer
CHASTE_CLASS_EXPORT(SimpleWntCellCycleModel)

#endif /*SIMPLEWNTCELLCYCLEMODEL_HPP_*/