Chaste Release::3.1
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00001 /* 00002 00003 Copyright (c) 2005-2012, University of Oxford. 00004 All rights reserved. 00005 00006 University of Oxford means the Chancellor, Masters and Scholars of the 00007 University of Oxford, having an administrative office at Wellington 00008 Square, Oxford OX1 2JD, UK. 00009 00010 This file is part of Chaste. 00011 00012 Redistribution and use in source and binary forms, with or without 00013 modification, are permitted provided that the following conditions are met: 00014 * Redistributions of source code must retain the above copyright notice, 00015 this list of conditions and the following disclaimer. 00016 * Redistributions in binary form must reproduce the above copyright notice, 00017 this list of conditions and the following disclaimer in the documentation 00018 and/or other materials provided with the distribution. 00019 * Neither the name of the University of Oxford nor the names of its 00020 contributors may be used to endorse or promote products derived from this 00021 software without specific prior written permission. 00022 00023 THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" 00024 AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE 00025 IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE 00026 ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE 00027 LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR 00028 CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE 00029 GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) 00030 HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT 00031 LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT 00032 OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. 00033 00034 */ 00035 00036 #include "AbstractSimpleCellCycleModel.hpp" 00037 #include "Exception.hpp" 00038 00039 AbstractSimpleCellCycleModel::AbstractSimpleCellCycleModel() 00040 { 00041 } 00042 00043 AbstractSimpleCellCycleModel::~AbstractSimpleCellCycleModel() 00044 { 00045 } 00046 00047 void AbstractSimpleCellCycleModel::Initialise() 00048 { 00049 SetG1Duration(); 00050 } 00051 00052 void AbstractSimpleCellCycleModel::InitialiseDaughterCell() 00053 { 00054 AbstractCellCycleModel::InitialiseDaughterCell(); 00055 SetG1Duration(); 00056 } 00057 00058 void AbstractSimpleCellCycleModel::SetG1Duration() 00059 { 00060 assert(mpCell != NULL); 00061 00062 switch (mpCell->GetCellProliferativeType()) 00063 { 00064 case STEM: 00065 mG1Duration = GetStemCellG1Duration(); 00066 break; 00067 case TRANSIT: 00068 mG1Duration = GetTransitCellG1Duration(); 00069 break; 00070 case DIFFERENTIATED: 00071 mG1Duration = DBL_MAX; 00072 break; 00073 default: 00074 NEVER_REACHED; 00075 } 00076 } 00077 00078 void AbstractSimpleCellCycleModel::ResetForDivision() 00079 { 00080 AbstractCellCycleModel::ResetForDivision(); 00081 mBirthTime = SimulationTime::Instance()->GetTime(); 00082 SetG1Duration(); 00083 } 00084 00085 void AbstractSimpleCellCycleModel::UpdateCellCyclePhase() 00086 { 00087 double time_since_birth = GetAge(); 00088 assert(time_since_birth >= 0); 00089 00090 if (mpCell->GetCellProliferativeType() == DIFFERENTIATED) 00091 { 00092 mCurrentCellCyclePhase = G_ZERO_PHASE; 00093 } 00094 else if (time_since_birth < GetMDuration()) 00095 { 00096 mCurrentCellCyclePhase = M_PHASE; 00097 } 00098 else if (time_since_birth < GetMDuration() + mG1Duration) 00099 { 00100 mCurrentCellCyclePhase = G_ONE_PHASE; 00101 } 00102 else if (time_since_birth < GetMDuration() + mG1Duration + GetSDuration()) 00103 { 00104 mCurrentCellCyclePhase = S_PHASE; 00105 } 00106 else if (time_since_birth < GetMDuration() + mG1Duration + GetSDuration() + GetG2Duration()) 00107 { 00108 mCurrentCellCyclePhase = G_TWO_PHASE; 00109 } 00110 } 00111 00112 void AbstractSimpleCellCycleModel::OutputCellCycleModelParameters(out_stream& rParamsFile) 00113 { 00114 // No new parameters to output 00115 00116 // Call method on direct parent class 00117 AbstractCellCycleModel::OutputCellCycleModelParameters(rParamsFile); 00118 }