Chaste  Release::3.4
CorriasBuistSMCModified.hpp
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35 
36 #ifndef CorriasBuistSMCModified_HPP_
37 #define CorriasBuistSMCModified_HPP_
38 
39 
40 #include "ChasteSerialization.hpp"
41 #include <boost/serialization/base_object.hpp>
42 #include "AbstractCardiacCell.hpp"
43 #include "AbstractStimulusFunction.hpp"
59 {
60  friend class boost::serialization::access;
68  template<class Archive>
69  void serialize(Archive & archive, const unsigned int version)
70  {
71  archive & boost::serialization::base_object<AbstractCardiacCell >(*this);
72  }
73 
74 private:
75 
82 
87 
88  double Cm;
91  double Asurf;
93  double VolCell;
94  double hCa;
95  double sCa;
97  /* concentrations */
98  double Ki;
99  double Nai;
100  double ACh;
101  double CaiRest;
103  /* maximum conductances*/
104  double gLVA_max; // (0.18 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
105  double gCaL_max; // (65.0 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
106  double gBK_max; // (45.7 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
107  double gKb_max; // (0.0144 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
108  double gKA_max; // (9.0 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
109  double gKr_max; // (35.0 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
110  double gNa_max; // (3.0 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
111  double gnsCC_max; // (50.0 nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
112  double gcouple; // 1.3 nS * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
113  double JCaExt_max;
115  /* Temperature corrections */
116  double Q10Ca;
117  double Q10K; //1.365
118  double Q10Na;
119  double Texp;
121  double T_correct_Ca ;
122  double T_correct_K ;
123  double T_correct_Na;
124  double T_correct_gBK; // (nS) * 1e-6 (mS/nS) / Asurf (mm2) = mS/mm2
125 
126  /* Nernst potentials */
127  double EK;
128  double ENa ;
129  double EnsCC;
131  double Ca_o;
132  double K_o;
133  double Na_o;
135  /* Nernst parameters */
136  double R;
137  double T;
138  double F;
139  double FoRT;
140  double RToF;
142 public:
143 
150  CorriasBuistSMCModified(boost::shared_ptr<AbstractIvpOdeSolver> pSolver, boost::shared_ptr<AbstractStimulusFunction> pIntracellularStimulus);
151 
156 
160  void VerifyStateVariables();
161 
168  double GetIIonic(const std::vector<double>* pStateVariables=NULL);
169 
177  void EvaluateYDerivatives(double time, const std::vector<double>& rY, std::vector<double>& rDY);
178 
179 
186  void SetFakeIccStimulusPresent(bool present);
187 
192 
197 
204  void SetCarbonMonoxideScaleFactor(double scaleFactor);
205 
210 
211 };
212 
213 
214 // Needs to be included last
217 
218 namespace boost
219 {
220  namespace serialization
221  {
222  template<class Archive>
223  inline void save_construct_data(
224  Archive & ar, const CorriasBuistSMCModified * t, const unsigned int fileVersion)
225  {
226  const boost::shared_ptr<AbstractIvpOdeSolver> p_solver = t->GetSolver();
227  const boost::shared_ptr<AbstractStimulusFunction> p_stimulus = t->GetStimulusFunction();
228  ar << p_solver;
229  ar << p_stimulus;
230  }
231 
232  template<class Archive>
233  inline void load_construct_data(
234  Archive & ar, CorriasBuistSMCModified * t, const unsigned int fileVersion)
235  {
236  boost::shared_ptr<AbstractIvpOdeSolver> p_solver;
237  boost::shared_ptr<AbstractStimulusFunction> p_stimulus;
238  ar >> p_solver;
239  ar >> p_stimulus;
240  ::new(t)CorriasBuistSMCModified(p_solver, p_stimulus);
241  }
242 
243  }
244 
245 }
246 
247 #endif // CorriasBuistSMCModified_HPP_
double SetCarbonMonoxideScaleFactor()
const boost::shared_ptr< AbstractIvpOdeSolver > GetSolver() const
CorriasBuistSMCModified(boost::shared_ptr< AbstractIvpOdeSolver > pSolver, boost::shared_ptr< AbstractStimulusFunction > pIntracellularStimulus)
void EvaluateYDerivatives(double time, const std::vector< double > &rY, std::vector< double > &rDY)
void SetFakeIccStimulusPresent(bool present)
double GetIIonic(const std::vector< double > *pStateVariables=NULL)
boost::shared_ptr< AbstractStimulusFunction > GetStimulusFunction()
#define CHASTE_CLASS_EXPORT(T)
void serialize(Archive &archive, const unsigned int version)