LuoRudySpiralWaveCellFactory.hpp

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#ifndef LUORUDYSPIRALWAVECELLFACTORY_HPP_
#define LUORUDYSPIRALWAVECELLFACTORY_HPP_

#include "LuoRudy1991BackwardEuler.hpp"
#include "AbstractCardiacCellFactory.hpp"
#include "MultiStimulus.hpp"
#include "SimpleStimulus.hpp"

class LuoRudySpiralWaveCellFactory : public AbstractCardiacCellFactory<2>
{
private:
    boost::shared_ptr<SimpleStimulus> mpS1Stimulus;
    boost::shared_ptr<SimpleStimulus> mpS2Stimulus;
    boost::shared_ptr<MultiStimulus> mpBothStimulus;
    double mXExtent;
    double mYExtent;
public:
    LuoRudySpiralWaveCellFactory(double xExtent, double yExtent)
        : AbstractCardiacCellFactory<2>(),
          mpS1Stimulus(new SimpleStimulus(-50000.0, 2, 0)),
          mpS2Stimulus(new SimpleStimulus(-70000.0, 2, 45)),
          mpBothStimulus(new MultiStimulus()),
          mXExtent(xExtent),
          mYExtent(yExtent)
    {
        mpBothStimulus->AddStimulus(mpS1Stimulus);
        mpBothStimulus->AddStimulus(mpS2Stimulus);
    }

    AbstractCardiacCell* CreateCardiacCellForTissueNode(Node<2>* pNode)
    {
        double x = pNode->rGetLocation()[0];
        double y = pNode->rGetLocation()[1];

        double x_threshold_for_S1 = 0.1 + 1e-6;
        double x_threshold_for_S2 = mXExtent*0.6;
        double y_threshold_for_S2 = mYExtent*0.5;

        AbstractCardiacCell* p_cell;
        if ( x < x_threshold_for_S1 )
        {
            if (y<y_threshold_for_S2)
            {
                p_cell = new CellLuoRudy1991FromCellMLBackwardEuler(mpSolver, mpBothStimulus);
            }
            else
            {
                p_cell = new CellLuoRudy1991FromCellMLBackwardEuler(mpSolver, mpS1Stimulus);
            }
        }
        else if ( (x < x_threshold_for_S2) && (y < y_threshold_for_S2) )
        {
            p_cell = new CellLuoRudy1991FromCellMLBackwardEuler(mpSolver, mpS2Stimulus);
        }
        else
        {
            p_cell = new CellLuoRudy1991FromCellMLBackwardEuler(mpSolver, this->mpZeroStimulus);
        }

        // Alter parameters to match those used in
        // Qu et al. Origins of Spiral Wave Meander and Breakup... Annals of Biomedical Eng. 28:755-771 (2000).
        p_cell->SetParameter("membrane_L_type_calcium_current_conductance",0); // slow inward current in original model.

        unsigned node_index = pNode->GetIndex();
        if (node_index==0)
        {
//            std::cout << "[K_o] = " << p_cell->GetAnyVariable("extracellular_potassium_concentration") << "mM \n";
//            std::cout << "[K_i] = " << p_cell->GetAnyVariable("cytosolic_potassium_concentration") << "mM \n";
//            std::cout << "[Na_o] = " << p_cell->GetAnyVariable("extracellular_sodium_concentration") << "mM \n";
//            std::cout << "[Na_i] = " << p_cell->GetAnyVariable("cytosolic_sodium_concentration") << "mM \n";
            std::cout << "G_si = " << p_cell->GetAnyVariable("membrane_L_type_calcium_current_conductance") << "\n";
//            std::cout << "G_Na = " << p_cell->GetAnyVariable("membrane_fast_sodium_current_conductance") << "mM \n";
//            std::cout << "G_K = " << p_cell->GetAnyVariable("membrane_rapid_delayed_rectifier_potassium_current_conductance") << "mM \n";
//            std::cout << "G_K1 = " << p_cell->GetAnyVariable("membrane_inward_rectifier_potassium_current_conductance") << "mM \n";
        }
        return p_cell;
    }
};

#endif // LUORUDYSPIRALWAVECELLFACTORY_HPP_