CheckReadyToDivideAndPhaseIsUpdated.hpp

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*/
 
#ifndef CHECKREADYTODIVIDEANDPHASEISUPDATED_HPP_
#define CHECKREADYTODIVIDEANDPHASEISUPDATED_HPP_
 
#include <cxxtest/TestSuite.h>
#include <cmath>
#include "AbstractSimpleCellCycleModel.hpp"
#include "AbstractPhaseBasedCellCycleModel.hpp"
#include "DifferentiatedCellProliferativeType.hpp"
 
void CheckReadyToDivideAndPhaseIsUpdated(AbstractPhaseBasedCellCycleModel* pModel,
                                         double g1Duration,
                                         double g2Duration=DBL_MAX)
{
    if (g2Duration==DBL_MAX)
    {
        g2Duration = pModel->GetG2Duration();
    }
 
    double age = pModel->GetAge();
 
    const double G1TOL = 1e-5; // how accurate the expected G1 duration is
 
    // If the G1 duration is incorrect, print out the mismatch
    if ((pModel->GetCell()->GetCellProliferativeType()->IsType<DifferentiatedCellProliferativeType>()) &&
        (age >= pModel->GetMDuration()) &&
        (pModel->GetG1Duration() != DOUBLE_UNSET) &&
        (fabs(pModel->GetG1Duration() - g1Duration) > G1TOL))
    {
        std::cout << "G1 duration mismatch: actual = " << pModel->GetG1Duration()
                  << ", expected = " << g1Duration
                  << std::endl;
    }
 
    if (pModel->GetCell()->GetCellProliferativeType()->IsType<DifferentiatedCellProliferativeType>())
    {
        // If the cell is differentiated, then it must be in G0 phase and must never divide
        TS_ASSERT_EQUALS(pModel->ReadyToDivide(), false);
        TS_ASSERT_EQUALS(pModel->GetCurrentCellCyclePhase(), G_ZERO_PHASE);
    }
    else if (age < pModel->GetMDuration())
    {
        // If the cell in M phase, then it must not be ready to divide
        TS_ASSERT_EQUALS(pModel->ReadyToDivide(), false);
        TS_ASSERT_EQUALS(pModel->GetCurrentCellCyclePhase(), M_PHASE);
    }
    else if (age < pModel->GetMDuration() + g1Duration - G1TOL)
    {
        // The next cell cycle phase after M is G1; cells in G1 phase
        // must still not be ready to divide
        TS_ASSERT_EQUALS(pModel->ReadyToDivide(), false);
        TS_ASSERT_EQUALS(pModel->GetCurrentCellCyclePhase(), G_ONE_PHASE);
 
        // If the cell is not in G1 phase when it should be, print out the mismatch
        if (pModel->GetCurrentCellCyclePhase() != G_ONE_PHASE)
        {
            std::cout << "Expected G1: " << g1Duration
                      << "; actual: " << pModel->GetG1Duration()
                      << "; age = " << age
                      << "; G1-S transition = " << pModel->GetMDuration() + g1Duration
                      << std::endl;
        }
    }
    else if (age < pModel->GetMDuration() + g1Duration + pModel->GetSDuration() - G1TOL)
    {
        // The next cell cycle phase after G1 is S; cells in S phase
        // must still not be ready to divide
        TS_ASSERT_EQUALS(pModel->ReadyToDivide(), false);
        TS_ASSERT_EQUALS(pModel->GetCurrentCellCyclePhase(), S_PHASE);
    }
    else if (age < pModel->GetMDuration() + g1Duration + pModel->GetSDuration() + g2Duration  - G1TOL)
    {
        // The next cell cycle phase after S is G2; cells in G2 phase
        // must still not be ready to divide
        TS_ASSERT_EQUALS(pModel->ReadyToDivide(), false);
        TS_ASSERT_EQUALS(pModel->GetCurrentCellCyclePhase(), G_TWO_PHASE);
    }
    else
    {
        // Cells must be ready to divide as soon as they leave G2 phase
        TS_ASSERT_EQUALS(pModel->ReadyToDivide(), true);
    }
}
 
void CheckReadyToDivideIsUpdated(AbstractSimpleCellCycleModel* pModel,
                                 double cellCycleDuration)
{
    double age = pModel->GetAge();
 
    const double CCDTOL = 1e-5; // how accurate the expected CCD duration is
 
    // If the CCD duration is incorrect, print out the mismatch
    if ((pModel->GetCellCycleDuration() != DOUBLE_UNSET) &&
        (fabs(pModel->GetCellCycleDuration() - cellCycleDuration) > CCDTOL))
    {
        std::cout << "CCD duration mismatch: actual = " << pModel->GetCellCycleDuration()
                  << ", expected = " << cellCycleDuration
                  << std::endl;
    }
 
    // Check ReadyToDivide is updated correctly.
    if (pModel->GetCell()->GetCellProliferativeType()->IsType<DifferentiatedCellProliferativeType>())
    {
        // If the cell is differentiated, then it must be in G0 phase and must never divide
        TS_ASSERT_EQUALS(pModel->ReadyToDivide(), false);
    }
    else if (age < cellCycleDuration)
    {
        TS_ASSERT_EQUALS(pModel->ReadyToDivide(), false);
    }
    else
    {
        TS_ASSERT_EQUALS(pModel->ReadyToDivide(), true);
    }
}
 
 
#endif /*CHECKREADYTODIVIDEANDPHASEISUPDATED_HPP_*/