#include <CorriasBuistICCModified.hpp>

Inheritance diagram for CorriasBuistICCModified:

Collaboration diagram for CorriasBuistICCModified:

Public Member Functions
	CorriasBuistICCModified (boost::shared_ptr< AbstractIvpOdeSolver > pSolver, boost::shared_ptr< AbstractStimulusFunction > pIntracellularStimulus)

	~CorriasBuistICCModified ()

void	VerifyStateVariables ()

double	GetIIonic (const std::vector< double > *pStateVariables=NULL)

void	EvaluateYDerivatives (double time, const std::vector< double > &rY, std::vector< double > &rDY)

void	SetFractionOfVDDRInPU (double fraction)

void	SetIP3Concentration (double concentration)

void	SetSercaPumpScaleFactor (double scaleFactor)

void	SetCarbonMonoxideScaleFactor (double scaleFactor)

double	GetCarbonMonoxideScaleFactor ()

Public Member Functions inherited from AbstractCardiacCell
	AbstractCardiacCell (boost::shared_ptr< AbstractIvpOdeSolver > pOdeSolver, unsigned numberOfStateVariables, unsigned voltageIndex, boost::shared_ptr< AbstractStimulusFunction > pIntracellularStimulus)

virtual	~AbstractCardiacCell ()

void	Init ()

void	SetTimestep (double dt)

virtual void	SolveAndUpdateState (double tStart, double tEnd)

virtual OdeSolution	Compute (double tStart, double tEnd, double tSamp=0.0)

virtual void	ComputeExceptVoltage (double tStart, double tEnd)

void	SetVoltage (double voltage)

double	GetVoltage ()

unsigned	GetNumberOfStateVariables () const

unsigned	GetNumberOfParameters () const

std::vector< double >	GetStdVecStateVariables ()

const std::vector< std::string > &	rGetStateVariableNames () const

void	SetStateVariables (const std::vector< double > &rVariables)

void	SetStateVariable (unsigned index, double newValue)

void	SetStateVariable (const std::string &rName, double newValue)

double	GetAnyVariable (const std::string &rName, double time=0.0)

double	GetParameter (const std::string &rParameterName)

double	GetParameter (unsigned parameterIndex)

void	SetParameter (const std::string &rParameterName, double value)

virtual void	SetState (CellModelState state)

virtual void	SetSlowValues (const std::vector< double > &rSlowValues)

virtual void	GetSlowValues (std::vector< double > &rSlowValues)

virtual bool	IsFastOnly ()

virtual void	AdjustOutOfRangeSlowValues (std::vector< double > &rSlowValues)

virtual unsigned	GetNumSlowValues ()

Public Member Functions inherited from AbstractCardiacCellInterface
	AbstractCardiacCellInterface (boost::shared_ptr< AbstractIvpOdeSolver > pOdeSolver, unsigned voltageIndex, boost::shared_ptr< AbstractStimulusFunction > pIntracellularStimulus)

virtual	~AbstractCardiacCellInterface ()

unsigned	GetVoltageIndex ()

void	SetStimulusFunction (boost::shared_ptr< AbstractStimulusFunction > pStimulus)

double	GetStimulus (double time)

void	SetIntracellularStimulusFunction (boost::shared_ptr< AbstractStimulusFunction > pStimulus)

double	GetIntracellularStimulus (double time)

double	GetIntracellularAreaStimulus (double time)

void	SetUsedInTissueSimulation (bool tissue=true)

virtual boost::shared_ptr< RegularStimulus >	UseCellMLDefaultStimulus ()

bool	HasCellMLDefaultStimulus ()

virtual AbstractLookupTableCollection *	GetLookupTableCollection ()

boost::shared_ptr< AbstractStimulusFunction >	GetStimulusFunction ()

const boost::shared_ptr< AbstractStimulusFunction >	GetStimulusFunction () const

const boost::shared_ptr< AbstractIvpOdeSolver >	GetSolver () const

void	SetSolver (boost::shared_ptr< AbstractIvpOdeSolver > pSolver)

virtual void	SetVoltageDerivativeToZero (bool clamp=true)

void	SetFixedVoltage (double voltage)

virtual void	SetStretch (double stretch)

virtual double	GetIntracellularCalciumConcentration ()

Public Member Functions inherited from AbstractOdeSystem
	AbstractOdeSystem (unsigned numberOfStateVariables)

virtual	~AbstractOdeSystem ()

virtual bool	CalculateStoppingEvent (double time, const std::vector< double > &rY)

virtual double	CalculateRootFunction (double time, const std::vector< double > &rY)

bool	GetUseAnalyticJacobian ()

const std::vector< double > &	rGetConstStateVariables () const

Public Member Functions inherited from AbstractParameterisedSystem< std::vector< double > >
	AbstractParameterisedSystem (unsigned numberOfStateVariables)

std::vector< double > &	rGetStateVariables ()

std::vector< double >	GetStateVariables ()

void	SetStateVariables (const std::vector< double > &rStateVariables)

double	GetStateVariable (unsigned index) const

double	GetStateVariable (const std::string &rName) const

void	SetStateVariable (unsigned index, double newValue)

void	SetStateVariable (const std::string &rName, double newValue)

void	SetDefaultInitialConditions (const std::vector< double > &rInitialConditions)

void	SetDefaultInitialCondition (unsigned index, double initialCondition)

std::vector< double >	GetInitialConditions () const

void	ResetToInitialConditions ()

double	GetParameter (unsigned index) const

double	GetParameter (const std::string &rName) const

void	SetParameter (const std::string &rName, double value)

void	SetParameter (unsigned index, double value)

double	GetAnyVariable (unsigned index, double time=0.0, std::vector< double > *pDerivedQuantities=NULL)

double	GetAnyVariable (const std::string &rName, double time=0.0, std::vector< double > *pDerivedQuantities=NULL)

void	SetAnyVariable (unsigned index, double value)

void	SetAnyVariable (const std::string &rName, double value)

virtual std::vector< double >	ComputeDerivedQuantities (double time, const std::vector< double > &rState)

std::vector< double >	ComputeDerivedQuantitiesFromCurrentState (double time)

Public Member Functions inherited from AbstractUntemplatedParameterisedSystem
	AbstractUntemplatedParameterisedSystem (unsigned numberOfStateVariables)

virtual	~AbstractUntemplatedParameterisedSystem ()

boost::shared_ptr< const AbstractOdeSystemInformation >	GetSystemInformation () const

std::string	GetSystemName () const

unsigned	GetNumberOfAttributes () const

bool	HasAttribute (const std::string &rName) const

double	GetAttribute (const std::string &rName) const

unsigned	GetNumberOfStateVariables () const

const std::vector< std::string > &	rGetStateVariableNames () const

const std::vector< std::string > &	rGetStateVariableUnits () const

unsigned	GetStateVariableIndex (const std::string &rName) const

bool	HasStateVariable (const std::string &rName) const

std::string	GetStateVariableUnits (unsigned index) const

unsigned	GetNumberOfParameters () const

const std::vector< std::string > &	rGetParameterNames () const

const std::vector< std::string > &	rGetParameterUnits () const

unsigned	GetParameterIndex (const std::string &rName) const

bool	HasParameter (const std::string &rName) const

std::string	GetParameterUnits (unsigned index) const

unsigned	GetNumberOfDerivedQuantities () const

const std::vector< std::string > &	rGetDerivedQuantityNames () const

const std::vector< std::string > &	rGetDerivedQuantityUnits () const

unsigned	GetDerivedQuantityIndex (const std::string &rName) const

bool	HasDerivedQuantity (const std::string &rName) const

std::string	GetDerivedQuantityUnits (unsigned index) const

unsigned	GetAnyVariableIndex (const std::string &rName) const

bool	HasAnyVariable (const std::string &rName) const

std::string	GetAnyVariableUnits (unsigned index) const

std::string	GetAnyVariableUnits (const std::string &rName) const

Private Member Functions
template<class Archive >
void	serialize (Archive &archive, const unsigned int version)

Private Attributes
double	mFractionOfVDDRInPU

double	mIP3Concentration

double	mScaleFactorSerca

double	mScaleFactorCarbonMonoxide

double	Ca_o

double	Cl_o

double	K_o

double	Na_o

double	R

double	T

double	F

double	FoRT

double	RToF

double	Cm

double	Asurf_in_cm_square

double	Asurf

double	Cl_i

double	K_i

double	Na_i

double	P_cyto

double	Vol

double	fc

double	fe

double	fm

double	Q10Ca

double	Q10K

double	Q10Na

double	T_exp

double	G_max_BK

double	G_max_CaCl

double	G_max_ERG

double	G_max_Ltype

double	G_max_NSCC

double	G_max_Na

double	G_max_VDDR

double	G_max_bk

double	G_max_kv11

double	J_max_PMCA

double	J_max_PMCA_PU

double	J_ERleak

double	J_max_leak

double	Jmax_IP3

double	Jmax_NaCa

double	Jmax_serca

double	Jmax_uni

double	NaPerm_o_Kperm

double	L

double	P_ER

double	P_PU

double	P_mito

double	b

double	na

double	K_Ca

double	K_Na

double	K_act

double	K_trans

double	k_serca

double	conc

double	d_ACT

double	d_IP3

double	d_INH

double	tau_d_CaCl

double	tau_d_NSCC

double	tauh

double	deltaPsi_B

double	deltaPsi_star

double	deltaPsi

double	V_cyto

double	V_ER

double	V_MITO

double	V_PU

double	T_correction_Ca

double	T_correction_K

double	T_correction_Na

double	T_correction_BK

double	E_Na

double	E_K

double	E_Cl

double	E_NSCC

double	tau_d_ERG

double	tau_d_Ltype

double	tau_d_Na

double	tau_d_VDDR

double	tau_d_kv11

double	tau_f_Ltype

double	tau_f_Na

double	tau_f_VDDR

double	tau_f_ca_Ltype

double	tau_f_kv11

double	e2FoRTdPsiMdPsiS

double	ebFoRTdPsiMdPsiS

Friends
class	boost::serialization::access

Additional Inherited Members
Protected Member Functions inherited from AbstractParameterisedSystem< std::vector< double > >
std::string	DumpState (const std::string &rMessage)

std::string	DumpState (const std::string &rMessage, std::vector< double > Y)

std::string	DumpState (const std::string &rMessage, std::vector< double > Y, double time)

void	CheckParametersOnLoad (const std::vector< double > &rParameters, const std::vector< std::string > &rParameterNames)

Protected Attributes inherited from AbstractCardiacCell
double	mDt

Protected Attributes inherited from AbstractCardiacCellInterface
unsigned	mVoltageIndex

boost::shared_ptr< AbstractIvpOdeSolver >	mpOdeSolver

boost::shared_ptr< AbstractStimulusFunction >	mpIntracellularStimulus

bool	mSetVoltageDerivativeToZero

bool	mIsUsedInTissue

bool	mHasDefaultStimulusFromCellML

double	mFixedVoltage

Protected Attributes inherited from AbstractOdeSystem
bool	mUseAnalyticJacobian

Protected Attributes inherited from AbstractParameterisedSystem< std::vector< double > >
std::vector< double >	mStateVariables

std::vector< double >	mParameters

Protected Attributes inherited from AbstractUntemplatedParameterisedSystem
unsigned	mNumberOfStateVariables

boost::shared_ptr< AbstractOdeSystemInformation >	mpSystemInfo

Detailed Description

This class is a modified version of the model of a gastric Interstitial Cell of Cajal.

Reference publication is:

Corrias A, Buist ML. "Quantitative cellular description of gastric slow wave activity." Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G989-95. Epub 2008 Feb 14.

Modifications include:

simplified mitochondria dynamics (assumed mitochondrial potential is almost constant
ability to set K+ channels-affecting CO concentrations
ability to deflect a fraction of VDDR channels into the pacemaker unit.

Definition at line 59 of file CorriasBuistICCModified.hpp.

Constructor & Destructor Documentation

◆ CorriasBuistICCModified()

CorriasBuistICCModified::CorriasBuistICCModified	(	boost::shared_ptr< AbstractIvpOdeSolver >	pSolver,
		boost::shared_ptr< AbstractStimulusFunction >	pIntracellularStimulus
	)

Constructor

Parameters

pSolver	is a pointer to the ODE solver
pIntracellularStimulus	is a pointer to the intracellular stimulus

Definition at line 44 of file CorriasBuistICCModified.cpp.

References Asurf, Asurf_in_cm_square, b, Ca_o, Cl_i, Cl_o, Cm, conc, d_ACT, d_INH, d_IP3, deltaPsi, deltaPsi_B, deltaPsi_star, e2FoRTdPsiMdPsiS, E_Cl, E_K, E_Na, E_NSCC, ebFoRTdPsiMdPsiS, F, fc, fe, fm, FoRT, G_max_BK, G_max_bk, G_max_CaCl, G_max_ERG, G_max_kv11, G_max_Ltype, G_max_Na, G_max_NSCC, G_max_VDDR, HeartConfig::GetCapacitance(), AbstractCardiacCell::Init(), HeartConfig::Instance(), OdeSystemInformation< ODE_SYSTEM >::Instance(), J_ERleak, J_max_leak, J_max_PMCA, J_max_PMCA_PU, Jmax_IP3, Jmax_NaCa, Jmax_serca, Jmax_uni, K_act, K_Ca, K_i, K_Na, K_o, k_serca, K_trans, L, mFractionOfVDDRInPU, mIP3Concentration, AbstractUntemplatedParameterisedSystem::mpSystemInfo, mScaleFactorCarbonMonoxide, mScaleFactorSerca, na, Na_i, Na_o, NaPerm_o_Kperm, P_cyto, P_ER, P_mito, P_PU, Q10Ca, Q10K, Q10Na, R, RToF, T, T_correction_BK, T_correction_Ca, T_correction_K, T_correction_Na, T_exp, tau_d_CaCl, tau_d_ERG, tau_d_kv11, tau_d_Ltype, tau_d_Na, tau_d_NSCC, tau_d_VDDR, tau_f_ca_Ltype, tau_f_kv11, tau_f_Ltype, tau_f_Na, tau_f_VDDR, tauh, V_cyto, V_ER, V_MITO, V_PU, and Vol.

◆ ~CorriasBuistICCModified()

CorriasBuistICCModified::~CorriasBuistICCModified ( )

Destructor

Definition at line 184 of file CorriasBuistICCModified.cpp.

Member Function Documentation

◆ EvaluateYDerivatives()

void CorriasBuistICCModified::EvaluateYDerivatives	(	double	time,
		const std::vector< double > &	rY,
		std::vector< double > &	rDY
	)

virtual

Compute the RHS of the FitHugh-Nagumo system of ODEs

Parameters

time	the current time, in milliseconds
rY	current values of the state variables
rDY	to be filled in with derivatives

Implements AbstractOdeSystem.

Definition at line 272 of file CorriasBuistICCModified.cpp.

References Asurf, Ca_o, conc, d_ACT, d_INH, d_IP3, deltaPsi, deltaPsi_star, e2FoRTdPsiMdPsiS, E_Cl, E_K, E_Na, E_NSCC, ebFoRTdPsiMdPsiS, F, fc, fe, fm, FoRT, G_max_BK, G_max_bk, G_max_CaCl, G_max_ERG, G_max_kv11, G_max_Ltype, G_max_Na, G_max_NSCC, G_max_VDDR, AbstractCardiacCellInterface::GetStimulus(), J_ERleak, J_max_leak, J_max_PMCA, J_max_PMCA_PU, Jmax_IP3, Jmax_NaCa, Jmax_serca, Jmax_uni, K_act, K_Ca, K_Na, k_serca, K_trans, L, mFractionOfVDDRInPU, mIP3Concentration, mScaleFactorCarbonMonoxide, mScaleFactorSerca, AbstractCardiacCellInterface::mSetVoltageDerivativeToZero, na, Na_i, RToF, T_correction_BK, tau_d_CaCl, tau_d_ERG, tau_d_kv11, tau_d_Ltype, tau_d_Na, tau_d_NSCC, tau_d_VDDR, tau_f_ca_Ltype, tau_f_kv11, tau_f_Ltype, tau_f_Na, tau_f_VDDR, tauh, V_cyto, V_ER, V_MITO, and V_PU.

◆ GetCarbonMonoxideScaleFactor()

double CorriasBuistICCModified::GetCarbonMonoxideScaleFactor ( )

Returns: the Carbon Monoxide scale factor

Definition at line 211 of file CorriasBuistICCModified.cpp.

References mScaleFactorCarbonMonoxide.

◆ GetIIonic()

double CorriasBuistICCModified::GetIIonic ( const std::vector< double > * pStateVariables = NULL )

virtual

Calculates the ionic current

Parameters

pStateVariables the state variables of this model

Returns: the total ionic current

Now convert to microA over cm^2, the units that Chaste needs

Implements AbstractCardiacCellInterface.

Definition at line 216 of file CorriasBuistICCModified.cpp.

References Asurf, Ca_o, E_Cl, E_K, E_Na, E_NSCC, F, G_max_BK, G_max_bk, G_max_CaCl, G_max_ERG, G_max_kv11, G_max_Ltype, G_max_Na, G_max_NSCC, G_max_VDDR, J_max_PMCA, mScaleFactorCarbonMonoxide, AbstractParameterisedSystem< std::vector< double > >::rGetStateVariables(), RToF, T_correction_BK, and V_cyto.

◆ serialize()

template<class Archive >

void CorriasBuistICCModified::serialize	(	Archive &	archive,
		const unsigned int	version
	)

inlineprivate

Boost Serialization method for archiving/checkpointing. Archives the object and its member variables.

Parameters

archive	The boost archive.
version	The current version of this class.

Definition at line 70 of file CorriasBuistICCModified.hpp.

References mFractionOfVDDRInPU, mIP3Concentration, mScaleFactorCarbonMonoxide, and mScaleFactorSerca.

◆ SetCarbonMonoxideScaleFactor()

void CorriasBuistICCModified::SetCarbonMonoxideScaleFactor ( double scaleFactor )

Set the carbon monoxide scale factor. This will multiply the following currents: I_kv11, I_ERG, Ibk

Parameters

scaleFactor the scale factor that multiply the currents.

Definition at line 206 of file CorriasBuistICCModified.cpp.

References mScaleFactorCarbonMonoxide.

◆ SetFractionOfVDDRInPU()

void CorriasBuistICCModified::SetFractionOfVDDRInPU ( double fraction )

Sets the fraction of VDDR channels in the Pacemaker unit

Parameters

fraction the fraction of VDDr channels in the PU

Definition at line 196 of file CorriasBuistICCModified.cpp.

References mFractionOfVDDRInPU.

◆ SetIP3Concentration()

void CorriasBuistICCModified::SetIP3Concentration ( double concentration )

Set the value of IP3 concentration in the cell

Parameters

concentration the concentration of IP3

Definition at line 201 of file CorriasBuistICCModified.cpp.

References mIP3Concentration.

◆ SetSercaPumpScaleFactor()

void CorriasBuistICCModified::SetSercaPumpScaleFactor ( double scaleFactor )

Set a multiplying factor for the influx of Ca2+ into the Er via the SERCA pump (set to zero will block the SW generation)

Parameters

scaleFactor the scale factor (=0 –> no Ca2+ uptake into the ER and, consequently, no SW)

Definition at line 191 of file CorriasBuistICCModified.cpp.

References mScaleFactorSerca.

◆ VerifyStateVariables()

void CorriasBuistICCModified::VerifyStateVariables ( )

virtual

Now empty

Reimplemented from AbstractParameterisedSystem< std::vector< double > >.

Definition at line 188 of file CorriasBuistICCModified.cpp.

Friends And Related Symbol Documentation

◆ boost::serialization::access

friend class boost::serialization::access

friend

Definition at line 61 of file CorriasBuistICCModified.hpp.

Member Data Documentation

◆ Asurf

double CorriasBuistICCModified::Asurf

private

mm2

Definition at line 109 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ Asurf_in_cm_square

double CorriasBuistICCModified::Asurf_in_cm_square

private

cm2

Definition at line 108 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified().

◆ b

double CorriasBuistICCModified::b

private

dim

Definition at line 148 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified().

◆ Ca_o

double CorriasBuistICCModified::Ca_o

private

mM

Definition at line 95 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ Cl_i

double CorriasBuistICCModified::Cl_i

private

mM

Definition at line 110 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified().

◆ Cl_o

double CorriasBuistICCModified::Cl_o

private

mM

Definition at line 96 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified().

◆ Cm

double CorriasBuistICCModified::Cm

private

pF

Definition at line 107 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified().

◆ conc

double CorriasBuistICCModified::conc

private

mM

Definition at line 156 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ d_ACT

double CorriasBuistICCModified::d_ACT

private

mM

Definition at line 157 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ d_INH

double CorriasBuistICCModified::d_INH

private

mM

Definition at line 159 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ d_IP3

double CorriasBuistICCModified::d_IP3

private

mM

Definition at line 158 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ deltaPsi

double CorriasBuistICCModified::deltaPsi

private

mV

Definition at line 167 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ deltaPsi_B

double CorriasBuistICCModified::deltaPsi_B

private

mV

Definition at line 165 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified().

◆ deltaPsi_star

double CorriasBuistICCModified::deltaPsi_star

private

mV

Definition at line 166 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ e2FoRTdPsiMdPsiS

double CorriasBuistICCModified::e2FoRTdPsiMdPsiS

private

speed-up constant

Definition at line 206 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ E_Cl

double CorriasBuistICCModified::E_Cl

private

mV

Definition at line 188 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ E_K

double CorriasBuistICCModified::E_K

private

mV

Definition at line 187 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ E_Na

double CorriasBuistICCModified::E_Na

private

mV

Definition at line 186 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ E_NSCC

double CorriasBuistICCModified::E_NSCC

private

mV

Definition at line 189 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ ebFoRTdPsiMdPsiS

double CorriasBuistICCModified::ebFoRTdPsiMdPsiS

private

speed-up constant

Definition at line 207 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ F

double CorriasBuistICCModified::F

private

nC/nmol

Definition at line 103 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ fc

double CorriasBuistICCModified::fc

private

dim

Definition at line 115 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ fe

double CorriasBuistICCModified::fe

private

dim

Definition at line 116 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ fm

double CorriasBuistICCModified::fm

private

dim

Definition at line 117 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ FoRT

double CorriasBuistICCModified::FoRT

private

1/mV

Definition at line 104 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ G_max_BK

double CorriasBuistICCModified::G_max_BK

private

nS

Definition at line 123 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ G_max_bk

double CorriasBuistICCModified::G_max_bk

private

nS

Definition at line 130 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ G_max_CaCl

double CorriasBuistICCModified::G_max_CaCl

private

nS

Definition at line 124 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ G_max_ERG

double CorriasBuistICCModified::G_max_ERG

private

nS

Definition at line 125 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ G_max_kv11

double CorriasBuistICCModified::G_max_kv11

private

nS

Definition at line 131 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ G_max_Ltype

double CorriasBuistICCModified::G_max_Ltype

private

nS

Definition at line 126 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ G_max_Na

double CorriasBuistICCModified::G_max_Na

private

nS

Definition at line 128 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ G_max_NSCC

double CorriasBuistICCModified::G_max_NSCC

private

nS

Definition at line 127 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ G_max_VDDR

double CorriasBuistICCModified::G_max_VDDR

private

nS

Definition at line 129 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ J_ERleak

double CorriasBuistICCModified::J_ERleak

private

1/ms (1/s) * 1/1000 (ms/s) = 1/ms

Definition at line 136 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ J_max_leak

double CorriasBuistICCModified::J_max_leak

private

1/ms (1/s) * 1/1000 (ms/s) = 1/ms

Definition at line 137 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ J_max_PMCA

double CorriasBuistICCModified::J_max_PMCA

private

mM/ms (mM/s) * 1/1000 (s/ms) = mM/ms

Definition at line 134 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), and GetIIonic().

◆ J_max_PMCA_PU

double CorriasBuistICCModified::J_max_PMCA_PU

private

mM/ms (mM/s) * 1/1000 (s/ms) = mM/ms

Definition at line 135 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ Jmax_IP3

double CorriasBuistICCModified::Jmax_IP3

private

1/ms (1/s) * 1/1000 (ms/s) = 1/ms

Definition at line 138 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ Jmax_NaCa

double CorriasBuistICCModified::Jmax_NaCa

private

mM/ms (mM/s) * 1/1000 (s/ms) = mM/ms

Definition at line 139 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ Jmax_serca

double CorriasBuistICCModified::Jmax_serca

private

mM/ms (mM/s) * 1/1000 (s/ms) = mM/ms

Definition at line 140 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ Jmax_uni

double CorriasBuistICCModified::Jmax_uni

private

1/ms (1/s) * 1/1000 (ms/s) = 1/ms

Definition at line 141 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ K_act

double CorriasBuistICCModified::K_act

private

mM

Definition at line 153 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ K_Ca

double CorriasBuistICCModified::K_Ca

private

mM

Definition at line 151 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ K_i

double CorriasBuistICCModified::K_i

private

mM

Definition at line 111 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified().

◆ K_Na

double CorriasBuistICCModified::K_Na

private

mM

Definition at line 152 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ K_o

double CorriasBuistICCModified::K_o

private

mM

Definition at line 97 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified().

◆ k_serca

double CorriasBuistICCModified::k_serca

private

mM

Definition at line 155 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ K_trans

double CorriasBuistICCModified::K_trans

private

mM

Definition at line 154 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ L

double CorriasBuistICCModified::L

private

dim

Definition at line 144 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), and EvaluateYDerivatives().

◆ mFractionOfVDDRInPU

double CorriasBuistICCModified::mFractionOfVDDRInPU

private

fraction of VDDR channel in the PU, initialised to zero

Definition at line 82 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), serialize(), and SetFractionOfVDDRInPU().

◆ mIP3Concentration

double CorriasBuistICCModified::mIP3Concentration

private

the IP3 concentration, defaults to 0.0006 mM

Definition at line 84 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), serialize(), and SetIP3Concentration().

◆ mScaleFactorCarbonMonoxide

double CorriasBuistICCModified::mScaleFactorCarbonMonoxide

private

Scale factor for CO-affected currents Note that this the number that multiply the currents, hence it is not [CO], but a function of [CO] (for example, 2.8*[CO] - 0.1)

Definition at line 92 of file CorriasBuistICCModified.hpp.

Referenced by CorriasBuistICCModified(), EvaluateYDerivatives(), GetCarbonMonoxideScaleFactor(), GetIIonic(), serialize(), and SetCarbonMonoxideScaleFactor().