SimpleWntCellCycleModel Class Reference

#include <SimpleWntCellCycleModel.hpp>

Inheritance diagram for SimpleWntCellCycleModel:

Collaboration diagram for SimpleWntCellCycleModel:

List of all members.

Public Member Functions

SimpleWntCellCycleModel (unsigned dimension, bool useCellTypeDependentG1Duration=false)

void UpdateCellCyclePhase ()

void ResetForDivision ()

void InitialiseDaughterCell ()

AbstractCellCycleModel * CreateCellCycleModel ()

unsigned GetDimension ()

Protected Member Functions

void SetG1Duration ()

Private Member Functions

template<class Archive>

void serialize (Archive &archive, const unsigned int version)

double GetWntLevel ()

WntConcentrationType GetWntType ()

Private Attributes

bool mUseCellTypeDependentG1Duration

unsigned mDimension

Friends

class boost::serialization::access

Detailed Description

Simple Wnt-dependent cell cycle model

Definition at line 39 of file SimpleWntCellCycleModel.hpp.

Constructor & Destructor Documentation

SimpleWntCellCycleModel::SimpleWntCellCycleModel	(	unsigned	dimension,
		bool	useCellTypeDependentG1Duration = `false`
	)

Constructor - just a default, mBirthTime is now set in the AbstractCellCycleModel class. mG1Duration is set very high, it is set for the individual cells when InitialiseDaughterCell is called.

Parameters:

	dimension	the spatial dimension (needed by the templated class WntConcentration)
	useCellTypeDependentG1Duration	Whether the duration of the G1 phase is dependent on cell type

Definition at line 31 of file SimpleWntCellCycleModel.cpp.

Referenced by CreateCellCycleModel().

Member Function Documentation

template<class Archive>

void SimpleWntCellCycleModel::serialize	(	Archive &	archive,
		const unsigned int	version
	)			`[inline, private]`

Archive the cell cycle model, never used directly - boost uses this.

Parameters:

	archive	the archive
	version	the current version of this class

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 52 of file SimpleWntCellCycleModel.hpp.

References RandomNumberGenerator::Instance(), mDimension, and mUseCellTypeDependentG1Duration.

double SimpleWntCellCycleModel::GetWntLevel ( ) [private]

Get the Wnt level experienced by the cell.

Definition at line 88 of file SimpleWntCellCycleModel.cpp.

References WntConcentration< DIM >::GetWntLevel(), WntConcentration< DIM >::Instance(), mDimension, and AbstractCellCycleModel::mpCell.

Referenced by UpdateCellCyclePhase().

WntConcentrationType SimpleWntCellCycleModel::GetWntType ( ) [private]

Get the type of Wnt concentration (LINEAR, RADIAL, or NONE). This affects how the cell cycle phase is updated.

Definition at line 120 of file SimpleWntCellCycleModel.cpp.

References WntConcentration< DIM >::GetType(), WntConcentration< DIM >::Instance(), and mDimension.

Referenced by InitialiseDaughterCell(), and UpdateCellCyclePhase().

void SimpleWntCellCycleModel::SetG1Duration ( ) [protected, virtual]

Stochastically set the G1 duration. The G1 duration is taken from a normal distribution whose mean is the G1 duration given in TissueConfig for the cell type and whose standard deviation is 1.

Called on cell creation at the start of a simulation, and for both parent and daughter cells at cell division.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 50 of file SimpleWntCellCycleModel.cpp.

References TissueCell::GetCellType(), TissueConfig::GetMinimumGapDuration(), TissueConfig::GetStemCellG1Duration(), TissueConfig::GetTransitCellG1Duration(), RandomNumberGenerator::Instance(), TissueConfig::Instance(), AbstractCellCycleModel::mG1Duration, AbstractCellCycleModel::mpCell, mUseCellTypeDependentG1Duration, and RandomNumberGenerator::NormalRandomDeviate().

void SimpleWntCellCycleModel::UpdateCellCyclePhase ( ) [virtual]

Overridden UpdateCellCyclePhase() method.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 150 of file SimpleWntCellCycleModel.cpp.

References TissueCell::GetMutationState(), GetWntLevel(), TissueConfig::GetWntStemThreshold(), TissueConfig::GetWntTransitThreshold(), GetWntType(), TissueConfig::Instance(), AbstractCellCycleModel::mCurrentCellCyclePhase, AbstractCellCycleModel::mpCell, TissueCell::SetCellType(), and AbstractSimpleCellCycleModel::UpdateCellCyclePhase().

void SimpleWntCellCycleModel::ResetForDivision ( ) [virtual]

Overridden ResetForDivision() method.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 206 of file SimpleWntCellCycleModel.cpp.

References AbstractSimpleCellCycleModel::ResetForDivision().

void SimpleWntCellCycleModel::InitialiseDaughterCell ( ) [virtual]

Overridden InitialiseDaughterCell() method.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 212 of file SimpleWntCellCycleModel.cpp.

References GetWntType(), AbstractSimpleCellCycleModel::InitialiseDaughterCell(), AbstractCellCycleModel::mpCell, and TissueCell::SetCellType().

AbstractCellCycleModel * SimpleWntCellCycleModel::CreateCellCycleModel ( ) [virtual]

Overridden builder method to create new copies of this cell cycle model.

Implements AbstractCellCycleModel.

Definition at line 38 of file SimpleWntCellCycleModel.cpp.

References SimpleWntCellCycleModel().

unsigned SimpleWntCellCycleModel::GetDimension ( )

Get the spatial dimension.

Returns:: mDimension

Definition at line 44 of file SimpleWntCellCycleModel.cpp.

References mDimension.

Friends And Related Function Documentation

friend class boost::serialization::access [friend]

Needed for serialization.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 44 of file SimpleWntCellCycleModel.hpp.

Member Data Documentation

bool SimpleWntCellCycleModel::mUseCellTypeDependentG1Duration [private]

Whether to use different mean G1 durations for different cell types. For use in SetG1Duration().

Definition at line 67 of file SimpleWntCellCycleModel.hpp.

Referenced by serialize(), and SetG1Duration().

unsigned SimpleWntCellCycleModel::mDimension [private]

The spatial dimension (needed by the templated class WntConcentration).

Definition at line 72 of file SimpleWntCellCycleModel.hpp.

Referenced by GetDimension(), GetWntLevel(), GetWntType(), and serialize().

The documentation for this class was generated from the following files:

/tmp/release_1.1/cancer/src/tissue/cell/cycle/SimpleWntCellCycleModel.hpp
/tmp/release_1.1/cancer/src/tissue/cell/cycle/SimpleWntCellCycleModel.cpp


Public Member Functions
	SimpleWntCellCycleModel (unsigned dimension, bool useCellTypeDependentG1Duration=false)
void	UpdateCellCyclePhase ()
void	ResetForDivision ()
void	InitialiseDaughterCell ()
AbstractCellCycleModel *	CreateCellCycleModel ()
unsigned	GetDimension ()
Protected Member Functions
void	SetG1Duration ()
Private Member Functions
template<class Archive>
void	serialize (Archive &archive, const unsigned int version)
double	GetWntLevel ()
WntConcentrationType	GetWntType ()
Private Attributes
bool	mUseCellTypeDependentG1Duration
unsigned	mDimension
Friends
class	boost::serialization::access