ExponentialG1GenerationalCellCycleModel.cpp

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#include "ExponentialG1GenerationalCellCycleModel.hpp"
#include "Exception.hpp"
#include "StemCellProliferativeType.hpp"
#include "TransitCellProliferativeType.hpp"
#include "DifferentiatedCellProliferativeType.hpp"

ExponentialG1GenerationalCellCycleModel::ExponentialG1GenerationalCellCycleModel()
    : AbstractSimpleGenerationalCellCycleModel(),
      mRate(1.0/mTransitCellG1Duration)
{
}

ExponentialG1GenerationalCellCycleModel::ExponentialG1GenerationalCellCycleModel(const ExponentialG1GenerationalCellCycleModel& rModel)
   :  AbstractSimpleGenerationalCellCycleModel(rModel),
      mRate(rModel.mRate)
{
    /*
     * Initialize only the member variable defined in this class.
     *
     * The member variables mCurrentCellCyclePhase, mG1Duration,
     * mMinimumGapDuration, mStemCellG1Duration, mTransitCellG1Duration,
     * mSDuration, mG2Duration and mMDuration are initialized in the
     * AbstractPhaseBasedCellCycleModel constructor.
     *
     * The member variables mBirthTime, mReadyToDivide and mDimension
     * are initialized in the AbstractCellCycleModel constructor.
     *
     * Note that mG1Duration is (re)set as soon as InitialiseDaughterCell()
     * is called on the new cell-cycle model.
     */
}

AbstractCellCycleModel* ExponentialG1GenerationalCellCycleModel::CreateCellCycleModel()
{
    return new ExponentialG1GenerationalCellCycleModel(*this);
}

void ExponentialG1GenerationalCellCycleModel::SetG1Duration()
{
    RandomNumberGenerator* p_gen = RandomNumberGenerator::Instance();

    if (mpCell->GetCellProliferativeType()->IsType<StemCellProliferativeType>()
        || mpCell->GetCellProliferativeType()->IsType<TransitCellProliferativeType>() )
    {
        // Generate an exponential random number with mScale
        mG1Duration = p_gen->ExponentialRandomDeviate(mRate);
    }
    else if (mpCell->GetCellProliferativeType()->IsType<DifferentiatedCellProliferativeType>())
    {
        mG1Duration = DBL_MAX;
    }
    else
    {
        NEVER_REACHED;
    }
}

double ExponentialG1GenerationalCellCycleModel::GetRate()
{
    return mRate;
}

void ExponentialG1GenerationalCellCycleModel::SetRate(double rate)
{
    mRate = rate;

    // These are now set to the average value of the G1Duration
    SetTransitCellG1Duration(1.0/rate);
    SetStemCellG1Duration(1.0/rate);
}

void ExponentialG1GenerationalCellCycleModel::SetStemCellG1Duration(double stemCellG1Duration)
{
    assert(stemCellG1Duration > 0.0);
    mStemCellG1Duration = stemCellG1Duration;

    mRate = 1.0/stemCellG1Duration;
}

void ExponentialG1GenerationalCellCycleModel::SetTransitCellG1Duration(double transitCellG1Duration)
{
    assert(transitCellG1Duration > 0.0);
    mTransitCellG1Duration = transitCellG1Duration;

    mRate = 1.0/transitCellG1Duration;
}

void ExponentialG1GenerationalCellCycleModel::OutputCellCycleModelParameters(out_stream& rParamsFile)
{
     *rParamsFile << "\t\t\t<Rate>" << mRate << "</Rate>\n";

    // Call method on direct parent class
    AbstractSimpleGenerationalCellCycleModel::OutputCellCycleModelParameters(rParamsFile);
}

// Serialization for Boost >= 1.36
#include "SerializationExportWrapperForCpp.hpp"
CHASTE_CLASS_EXPORT(ExponentialG1GenerationalCellCycleModel)