SingleOdeWntCellCycleModel.hpp

/*

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*/

#ifndef SINGLEODEWNTCELLCYCLEMODEL_HPP_
#define SINGLEODEWNTCELLCYCLEMODEL_HPP_

#include "ChasteSerialization.hpp"
#include <boost/serialization/base_object.hpp>

#include <cfloat>

#include "SimpleWntCellCycleModel.hpp"
#include "Mirams2010WntOdeSystem.hpp"
#include "AbstractCellCycleModelOdeSolver.hpp"
#include "CellCycleModelOdeHandler.hpp"

class SingleOdeWntCellCycleModel : public SimpleWntCellCycleModel, public CellCycleModelOdeHandler
{
private:

    friend class boost::serialization::access;
    template<class Archive>
    void serialize(Archive & archive, const unsigned int version)
    {
        archive & boost::serialization::base_object<SimpleWntCellCycleModel>(*this);
        archive & boost::serialization::base_object<CellCycleModelOdeHandler>(*this);
        archive & mBetaCateninDivisionThreshold;
    }

    double mBetaCateninDivisionThreshold;

    void ChangeCellProliferativeTypeDueToCurrentBetaCateninLevel();

    virtual void AdjustOdeParameters(double currentTime);

protected:

    SingleOdeWntCellCycleModel(const SingleOdeWntCellCycleModel& rModel);

public:

    SingleOdeWntCellCycleModel(boost::shared_ptr<AbstractCellCycleModelOdeSolver> pOdeSolver = boost::shared_ptr<AbstractCellCycleModelOdeSolver>());

    void Initialise();

    void UpdateCellCyclePhase();

    AbstractCellCycleModel* CreateCellCycleModel();

    double GetBetaCateninConcentration();

    void SetBetaCateninDivisionThreshold(double betaCateninDivisionThreshold);

    double GetBetaCateninDivisionThreshold();

    virtual void OutputCellCycleModelParameters(out_stream& rParamsFile);
};

// Declare identifier for the serializer
#include "SerializationExportWrapper.hpp"
CHASTE_CLASS_EXPORT(SingleOdeWntCellCycleModel)
#include "CellCycleModelOdeSolverExportWrapper.hpp"
EXPORT_CELL_CYCLE_MODEL_ODE_SOLVER(SingleOdeWntCellCycleModel)

#endif /*SINGLEODEWNTCELLCYCLEMODEL_HPP_*/