#include <CellCycleTimesGenerator.hpp>

Inheritance diagram for CellCycleTimesGenerator:

Collaboration diagram for CellCycleTimesGenerator:

Public Member Functions
void	SetRandomSeed (unsigned randomSeed)

unsigned	GetRandomSeed ()

void	SetRate (double rate)

double	GetRate ()

void	GenerateCellCycleTimeSequence ()

double	GetNextCellCycleTime ()

Public Member Functions inherited from SerializableSingleton< CellCycleTimesGenerator >
SerializableSingleton < CellCycleTimesGenerator > *	GetSerializationWrapper () const

Static Public Member Functions
static CellCycleTimesGenerator *	Instance ()

static void	Destroy ()

Protected Member Functions
	CellCycleTimesGenerator ()

Private Member Functions
template<class Archive >
void	serialize (Archive &archive, const unsigned int version)

Private Attributes
unsigned	mRandomSeed

std::vector< double >	mCellCycleTimes

unsigned	mCurrentIndex

double	mRate

bool	mVectorCreated

Static Private Attributes
static CellCycleTimesGenerator *	mpInstance = NULL

Friends
class	boost::serialization::access

Detailed Description

This is a helper class for FixedSequenceCellCycleModel. It comprises a singleton class for producing a fixed stream of exponentially distributed G1 durations.

Definition at line 49 of file CellCycleTimesGenerator.hpp.

Constructor & Destructor Documentation

CellCycleTimesGenerator::CellCycleTimesGenerator ( )

protected

Protected constructor. Use Instance() to access the random number generator.

Definition at line 41 of file CellCycleTimesGenerator.cpp.

References mpInstance.

Referenced by Instance().

Member Function Documentation

void CellCycleTimesGenerator::Destroy ( )

static

Destroy the current instance of the cell cycle times generator. The next call to Instance will create a new instance. This method *must* be called before program exit, to avoid a memory leak.

Definition at line 59 of file CellCycleTimesGenerator.cpp.

References mpInstance.

void CellCycleTimesGenerator::GenerateCellCycleTimeSequence ( )

Generate the cell cycle time sequence

Definition at line 78 of file CellCycleTimesGenerator.cpp.

References EXCEPTION, RandomNumberGenerator::ExponentialRandomDeviate(), RandomNumberGenerator::Instance(), mCellCycleTimes, mCurrentIndex, mRandomSeed, mRate, mVectorCreated, and RandomNumberGenerator::Reseed().

double CellCycleTimesGenerator::GetNextCellCycleTime ( )

Get the next cell cycle time

Returns: next_cell_cycle_time the next cell cycle time in the sequence

Definition at line 119 of file CellCycleTimesGenerator.cpp.

References EXCEPTION, mCellCycleTimes, mCurrentIndex, and mVectorCreated.

Referenced by FixedSequenceCellCycleModel::SetG1Duration().

unsigned CellCycleTimesGenerator::GetRandomSeed ( )

Get the random seed for generating the sequence.

Returns: seed The random seed

Definition at line 73 of file CellCycleTimesGenerator.cpp.

References mRandomSeed.

double CellCycleTimesGenerator::GetRate ( )

Get the rate of the exponential distribution.

Returns: rate The rate of the distribution.

Definition at line 114 of file CellCycleTimesGenerator.cpp.

References mRate.

Referenced by FixedSequenceCellCycleModel::GetRate(), and FixedSequenceCellCycleModel::OutputCellCycleModelParameters().

CellCycleTimesGenerator * CellCycleTimesGenerator::Instance ( )

static

Returns: a pointer to the CellCycleTimesGenerator object. The object is created the first time this method is called.

Definition at line 50 of file CellCycleTimesGenerator.cpp.

References CellCycleTimesGenerator(), and mpInstance.

Referenced by FixedSequenceCellCycleModel::GetRate(), FixedSequenceCellCycleModel::OutputCellCycleModelParameters(), FixedSequenceCellCycleModel::serialize(), FixedSequenceCellCycleModel::SetG1Duration(), and FixedSequenceCellCycleModel::SetRate().

template<class Archive >

void CellCycleTimesGenerator::serialize	(	Archive &	archive,
		const unsigned int	version
	)

inlineprivate

Serialization of a CellCycleTimesGenerator object must be done with care. Do not serialize this singleton directly. Instead, serialize the object returned by GetSerializationWrapper.

Parameters

archive	the archive
version	the current version of this class

Definition at line 98 of file CellCycleTimesGenerator.hpp.

References mCellCycleTimes, mCurrentIndex, mRandomSeed, mRate, and mVectorCreated.

void CellCycleTimesGenerator::SetRandomSeed ( unsigned randomSeed )

Set the random seed for generating the sequence of G1 Durations.

Parameters

randomSeed the new seed

Definition at line 68 of file CellCycleTimesGenerator.cpp.

References mRandomSeed.

void CellCycleTimesGenerator::SetRate ( double rate )

Set the rate of the exponential distribution.

Parameters

rate

Definition at line 102 of file CellCycleTimesGenerator.cpp.

References EXCEPTION, mRate, and mVectorCreated.

Referenced by FixedSequenceCellCycleModel::SetRate().

Friends And Related Function Documentation

friend class boost::serialization::access

friend

Needed for serialization.

Definition at line 87 of file CellCycleTimesGenerator.hpp.

Member Data Documentation

std::vector<double> CellCycleTimesGenerator::mCellCycleTimes

private

The actual sequence of cell cycle times

Definition at line 64 of file CellCycleTimesGenerator.hpp.

Referenced by GenerateCellCycleTimeSequence(), GetNextCellCycleTime(), and serialize().

unsigned CellCycleTimesGenerator::mCurrentIndex

private

This index is used to keep track of where in the sequence mCellCycleTimes the simulation currently is. Whenever a cell divides, a new cell cycle time gets drawn from mCellCycleTimes and this counter is incremented by one.

Definition at line 72 of file CellCycleTimesGenerator.hpp.

Referenced by GenerateCellCycleTimeSequence(), GetNextCellCycleTime(), and serialize().

CellCycleTimesGenerator * CellCycleTimesGenerator::mpInstance = NULL

staticprivate

The singleton definition

Definition at line 54 of file CellCycleTimesGenerator.hpp.

Referenced by CellCycleTimesGenerator(), Destroy(), and Instance().

unsigned CellCycleTimesGenerator::mRandomSeed

private

The random seed used to generate the series of cell cycle times.

Definition at line 59 of file CellCycleTimesGenerator.hpp.

Referenced by GenerateCellCycleTimeSequence(), GetRandomSeed(), serialize(), and SetRandomSeed().