#include <ContactInhibitionCellCycleModel.hpp>

Inheritance diagram for ContactInhibitionCellCycleModel:

Collaboration diagram for ContactInhibitionCellCycleModel:

Public Member Functions
	ContactInhibitionCellCycleModel ()

void	UpdateCellCyclePhase ()

AbstractCellCycleModel *	CreateCellCycleModel ()

void	SetQuiescentVolumeFraction (double quiescentVolumeFraction)

double	GetQuiescentVolumeFraction () const

void	SetEquilibriumVolume (double equilibriumVolume)

double	GetEquilibriumVolume () const

double	GetCurrentQuiescentDuration () const

double	GetCurrentQuiescentOnsetTime () const

virtual void	OutputCellCycleModelParameters (out_stream &rParamsFile)

Public Member Functions inherited from AbstractSimplePhaseBasedCellCycleModel
	AbstractSimplePhaseBasedCellCycleModel ()

virtual	~AbstractSimplePhaseBasedCellCycleModel ()

virtual void	ResetForDivision ()

void	InitialiseDaughterCell ()

virtual void	Initialise ()

Public Member Functions inherited from AbstractPhaseBasedCellCycleModel
	AbstractPhaseBasedCellCycleModel ()

virtual	~AbstractPhaseBasedCellCycleModel ()

virtual bool	ReadyToDivide ()

CellCyclePhase	GetCurrentCellCyclePhase () const

virtual double	GetG1Duration () const

double	GetStemCellG1Duration () const

double	GetTransitCellG1Duration () const

double	GetSG2MDuration () const

virtual double	GetSDuration () const

virtual double	GetG2Duration () const

virtual double	GetMDuration () const

virtual void	SetStemCellG1Duration (double stemCellG1Duration)

virtual void	SetTransitCellG1Duration (double transitCellG1Duration)

void	SetSDuration (double sDuration)

void	SetG2Duration (double g2Duration)

void	SetMDuration (double mDuration)

virtual double	GetAverageTransitCellCycleTime ()

virtual double	GetAverageStemCellCycleTime ()

double	GetMinimumGapDuration () const

void	SetMinimumGapDuration (double minimumGapDuration)

Public Member Functions inherited from AbstractCellCycleModel
	AbstractCellCycleModel ()

virtual	~AbstractCellCycleModel ()

void	SetCell (CellPtr pCell)

CellPtr	GetCell ()

virtual void	SetBirthTime (double birthTime)

void	SetDimension (unsigned dimension)

unsigned	GetDimension () const

double	GetBirthTime () const

double	GetAge ()

virtual bool	CanCellTerminallyDifferentiate ()

void	OutputCellCycleModelInfo (out_stream &rParamsFile)

Public Member Functions inherited from Identifiable
virtual	~Identifiable ()

std::string	GetIdentifier () const

Protected Member Functions
	ContactInhibitionCellCycleModel (const ContactInhibitionCellCycleModel &rModel)

Protected Member Functions inherited from AbstractSimplePhaseBasedCellCycleModel
virtual void	SetG1Duration ()

	AbstractSimplePhaseBasedCellCycleModel (const AbstractSimplePhaseBasedCellCycleModel &rModel)

Protected Member Functions inherited from AbstractPhaseBasedCellCycleModel
	AbstractPhaseBasedCellCycleModel (const AbstractPhaseBasedCellCycleModel &rModel)

Protected Member Functions inherited from AbstractCellCycleModel
	AbstractCellCycleModel (const AbstractCellCycleModel &rModel)

Protected Attributes
double	mQuiescentVolumeFraction

double	mEquilibriumVolume

double	mCurrentQuiescentOnsetTime

double	mCurrentQuiescentDuration

Protected Attributes inherited from AbstractPhaseBasedCellCycleModel
CellCyclePhase	mCurrentCellCyclePhase

double	mG1Duration

double	mMinimumGapDuration

double	mStemCellG1Duration

double	mTransitCellG1Duration

double	mSDuration

double	mG2Duration

double	mMDuration

Protected Attributes inherited from AbstractCellCycleModel
CellPtr	mpCell

double	mBirthTime

bool	mReadyToDivide

unsigned	mDimension

Private Member Functions
template<class Archive >
void	serialize (Archive &archive, const unsigned int version)

Friends
class	boost::serialization::access

Detailed Description

Simple stress-based cell-cycle model.

A simple stress-dependent cell-cycle model that inherits from AbstractSimplePhaseBasedCellCycleModel. The duration of G1 phase depends on the local stress, interpreted here as deviation from target volume (or area/length in 2D/1D).

This model allows for quiescence imposed by transient periods of high stress, followed by relaxation.

Note that in this cell cycle model, quiescence is implemented by extending the G1 phase. If a cell is compressed during G2 or S phases then it will still divide, and thus cells whose volumes are smaller than the given threshold may still divide.

Definition at line 57 of file ContactInhibitionCellCycleModel.hpp.

Constructor & Destructor Documentation

ContactInhibitionCellCycleModel::ContactInhibitionCellCycleModel ( const ContactInhibitionCellCycleModel & rModel )

protected

Protected copy-constructor for use by CreateCellCycleModel. The only way for external code to create a copy of a cell cycle model is by calling that method, to ensure that a model of the correct subclass is created. This copy-constructor helps subclasses to ensure that all member variables are correctly copied when this happens.

This method is called by child classes to set member variables for a daughter cell upon cell division. Note that the parent cell cycle model will have had ResetForDivision() called just before CreateCellCycleModel() is called, so performing an exact copy of the parent is suitable behaviour. Any daughter-cell-specific initialisation can be done in InitialiseDaughterCell().

Parameters

rModel the cell cycle model to copy.

Definition at line 49 of file ContactInhibitionCellCycleModel.cpp.

ContactInhibitionCellCycleModel::ContactInhibitionCellCycleModel ( )

Constructor.

Definition at line 40 of file ContactInhibitionCellCycleModel.cpp.

Referenced by CreateCellCycleModel().