00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2011 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 00029 #ifndef LINEARSPRINGWITHVARIABLESPRINGCONSTANTSFORCE_HPP 00030 #define LINEARSPRINGWITHVARIABLESPRINGCONSTANTSFORCE_HPP 00031 00032 #include "GeneralisedLinearSpringForce.hpp" 00033 00034 #include "ChasteSerialization.hpp" 00035 #include <boost/serialization/base_object.hpp> 00036 00037 // Needed here to avoid serialization errors (on Boost<1.37) 00038 #include "ApcTwoHitCellMutationState.hpp" 00039 #include "BetaCateninOneHitCellMutationState.hpp" 00040 00044 template<unsigned DIM> 00045 class LinearSpringWithVariableSpringConstantsForce : public GeneralisedLinearSpringForce<DIM> 00046 { 00047 friend class TestLinearSpringWithVariableSpringConstantsForce; 00048 00049 private: 00050 00052 friend class boost::serialization::access; 00059 template<class Archive> 00060 void serialize(Archive & archive, const unsigned int version) 00061 { 00062 archive & boost::serialization::base_object<GeneralisedLinearSpringForce<DIM> >(*this); 00063 archive & mUseEdgeBasedSpringConstant; 00064 archive & mUseMutantSprings; 00065 archive & mMutantMutantMultiplier; 00066 archive & mNormalMutantMultiplier; 00067 archive & mUseBCatSprings; 00068 archive & mUseApoptoticSprings; 00069 archive & mBetaCatSpringScaler; 00070 archive & mApoptoticSpringTensionStiffness; 00071 archive & mApoptoticSpringCompressionStiffness; 00072 } 00073 00074 protected: 00075 00077 bool mUseEdgeBasedSpringConstant; 00078 00080 bool mUseMutantSprings; 00081 00083 double mMutantMutantMultiplier; 00084 00086 double mNormalMutantMultiplier; 00087 00089 bool mUseBCatSprings; 00090 00092 bool mUseApoptoticSprings; 00093 00095 double mBetaCatSpringScaler; 00096 00098 double mApoptoticSpringTensionStiffness; 00099 00101 double mApoptoticSpringCompressionStiffness; 00102 00103 public: 00104 00108 LinearSpringWithVariableSpringConstantsForce(); 00109 00113 ~LinearSpringWithVariableSpringConstantsForce(); 00114 00120 void SetEdgeBasedSpringConstant(bool useEdgeBasedSpringConstant); 00121 00130 void SetMutantSprings(bool useMutantSprings, double mutantMutantMultiplier=2, double normalMutantMultiplier=1.5); 00131 00137 void SetBetaCateninSprings(bool useBCatSprings); 00138 00144 void SetApoptoticSprings(bool useApoptoticSprings); 00145 00159 double VariableSpringConstantMultiplicationFactor(unsigned nodeAGlobalIndex, 00160 unsigned nodeBGlobalIndex, 00161 AbstractCellPopulation<DIM>& rCellPopulation, 00162 bool isCloserThanRestLength); 00163 00170 void AddForceContribution(std::vector<c_vector<double, DIM> >& rForces, 00171 AbstractCellPopulation<DIM>& rCellPopulation); 00172 00176 double GetBetaCatSpringScaler(); 00177 00183 void SetBetaCatSpringScaler(double betaCatSpringScaler); 00184 00188 double GetApoptoticSpringTensionStiffness(); 00189 00195 void SetApoptoticSpringTensionStiffness(double apoptoticSpringTensionStiffness); 00196 00200 double GetApoptoticSpringCompressionStiffness(); 00201 00207 void SetApoptoticSpringCompressionStiffness(double apoptoticSpringCompressionStiffness); 00208 00217 virtual void OutputForceParameters(out_stream& rParamsFile); 00218 }; 00219 00220 #include "SerializationExportWrapper.hpp" 00221 00222 EXPORT_TEMPLATE_CLASS_SAME_DIMS(LinearSpringWithVariableSpringConstantsForce) 00223 00224 00225 #endif /*LINEARSPRINGWITHVARIABLESPRINGCONSTANTSFORCE_HPP*/