StochasticOxygenBasedCellCycleModel.cpp

/*

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*/

#include "StochasticOxygenBasedCellCycleModel.hpp"
#include "ApoptoticCellProperty.hpp"
#include "CellPropertyRegistry.hpp"

StochasticOxygenBasedCellCycleModel::StochasticOxygenBasedCellCycleModel()
    : SimpleOxygenBasedCellCycleModel()
{
}

void StochasticOxygenBasedCellCycleModel::GenerateStochasticG2Duration()
{
    RandomNumberGenerator* p_gen = RandomNumberGenerator::Instance();

    double mean = AbstractCellCycleModel::GetG2Duration();
    double standard_deviation = 1.0;

    mStochasticG2Duration = p_gen->NormalRandomDeviate(mean, standard_deviation);

    // Check that the normal random deviate has not returned a small or negative G2 duration
    if (mStochasticG2Duration < mMinimumGapDuration)
    {
        mStochasticG2Duration = mMinimumGapDuration;
    }
}

void StochasticOxygenBasedCellCycleModel::InitialiseDaughterCell()
{
    SimpleOxygenBasedCellCycleModel::InitialiseDaughterCell();
    GenerateStochasticG2Duration();
}

void StochasticOxygenBasedCellCycleModel::Initialise()
{
    AbstractSimpleCellCycleModel::Initialise();
    GenerateStochasticG2Duration();
}

void StochasticOxygenBasedCellCycleModel::ResetForDivision()
{
    SimpleOxygenBasedCellCycleModel::ResetForDivision();
    GenerateStochasticG2Duration();
}

double StochasticOxygenBasedCellCycleModel::GetG2Duration()
{
    return mStochasticG2Duration;
}

AbstractCellCycleModel* StochasticOxygenBasedCellCycleModel::CreateCellCycleModel()
{
    // Create a new cell-cycle model
    StochasticOxygenBasedCellCycleModel* p_model = new StochasticOxygenBasedCellCycleModel();

    /*
     * Set each member variable of the new cell-cycle model that inherits
     * its value from the parent.
     *
     * Note 1: some of the new cell-cycle model's member variables (namely
     * mBirthTime, mCurrentCellCyclePhase, mReadyToDivide, mTimeSpentInG1Phase,
     * mCurrentHypoxicDuration, mCurrentHypoxiaOnsetTime) will already have been
     * correctly initialized in its constructor.
     *
     * Note 2: one or more of the new cell-cycle model's member variables
     * may be set/overwritten as soon as InitialiseDaughterCell() is called on
     * the new cell-cycle model.
     */
    p_model->SetBirthTime(mBirthTime);
    p_model->SetDimension(mDimension);
    p_model->SetMinimumGapDuration(mMinimumGapDuration);
    p_model->SetStemCellG1Duration(mStemCellG1Duration);
    p_model->SetTransitCellG1Duration(mTransitCellG1Duration);
    p_model->SetSDuration(mSDuration);
    p_model->SetG2Duration(mG2Duration);
    p_model->SetMDuration(mMDuration);
    p_model->SetHypoxicConcentration(mHypoxicConcentration);
    p_model->SetQuiescentConcentration(mQuiescentConcentration);
    p_model->SetCriticalHypoxicDuration(mCriticalHypoxicDuration);
    p_model->SetCurrentHypoxiaOnsetTime(mCurrentHypoxiaOnsetTime);

    return p_model;
}

void StochasticOxygenBasedCellCycleModel::OutputCellCycleModelParameters(out_stream& rParamsFile)
{
    // No new parameters to output

    // Call method on direct parent class
    SimpleOxygenBasedCellCycleModel::OutputCellCycleModelParameters(rParamsFile);
}

// Serialization for Boost >= 1.36
#include "SerializationExportWrapperForCpp.hpp"
CHASTE_CLASS_EXPORT(StochasticOxygenBasedCellCycleModel)