BiasedBernoulliTrialCellCycleModel.cpp

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*/
 
#include "BiasedBernoulliTrialCellCycleModel.hpp"
#include "DifferentiatedCellProliferativeType.hpp"
 
BiasedBernoulliTrialCellCycleModel::BiasedBernoulliTrialCellCycleModel()
    : AbstractCellCycleModel(),
      mMaxDivisionProbability(0.1),
      mMinimumDivisionAge(1.0)
{
}
 
BiasedBernoulliTrialCellCycleModel::BiasedBernoulliTrialCellCycleModel(const BiasedBernoulliTrialCellCycleModel& rModel)
   : AbstractCellCycleModel(rModel),
     mMaxDivisionProbability(rModel.mMaxDivisionProbability),
     mMinimumDivisionAge(rModel.mMinimumDivisionAge)
{
    /*
     * Initialize only those member variables defined in this class.
     *
     * The member variables mBirthTime, mReadyToDivide and mDimension
     * are initialized in the AbstractCellCycleModel constructor.
     */
}
 
bool BiasedBernoulliTrialCellCycleModel::ReadyToDivide()
{
    assert(mpCell != nullptr);
 
    if (!mReadyToDivide)
    {
        if (GetAge() > mMinimumDivisionAge)
        {
            double dt = SimulationTime::Instance()->GetTimeStep();
            double p = mpCell->GetCellData()->GetItem("bias");
            assert(p >= 0.0 && p <= 1.0);
            if (!(mpCell->GetCellProliferativeType()->IsType<DifferentiatedCellProliferativeType>()))
            {
                RandomNumberGenerator* p_gen = RandomNumberGenerator::Instance();
                if (p_gen->ranf() < p*mMaxDivisionProbability*dt)
                {
                    mReadyToDivide = true;
                }
            }
        }
    }
    return mReadyToDivide;
}
 
AbstractCellCycleModel* BiasedBernoulliTrialCellCycleModel::CreateCellCycleModel()
{
    return new BiasedBernoulliTrialCellCycleModel(*this);
}
 
void BiasedBernoulliTrialCellCycleModel::SetMaxDivisionProbability(double maxDivisionProbability)
{
    assert(maxDivisionProbability >= 0.0 && maxDivisionProbability <= 1.0);
    mMaxDivisionProbability = maxDivisionProbability;
}
 
double BiasedBernoulliTrialCellCycleModel::GetMaxDivisionProbability()
{
    return mMaxDivisionProbability;
}
 
void BiasedBernoulliTrialCellCycleModel::SetMinimumDivisionAge(double minimumDivisionAge)
{
    assert(minimumDivisionAge >= 0.0);
    mMinimumDivisionAge = minimumDivisionAge;
}
 
double BiasedBernoulliTrialCellCycleModel::GetMinimumDivisionAge()
{
    return mMinimumDivisionAge;
}
 
double BiasedBernoulliTrialCellCycleModel::GetAverageTransitCellCycleTime()
{
    return 1.0/mMaxDivisionProbability;
}
 
double BiasedBernoulliTrialCellCycleModel::GetAverageStemCellCycleTime()
{
    return 1.0/mMaxDivisionProbability;
}
 
void BiasedBernoulliTrialCellCycleModel::OutputCellCycleModelParameters(out_stream& rParamsFile)
{
    *rParamsFile << "\t\t\t<MaxDivisionProbability>" << mMaxDivisionProbability << "</MaxDivisionProbability>\n";
    *rParamsFile << "\t\t\t<MinimumDivisionAge>" << mMinimumDivisionAge << "</MinimumDivisionAge>\n";
 
    // Call method on direct parent class
    AbstractCellCycleModel::OutputCellCycleModelParameters(rParamsFile);
}
 
// Serialization for Boost >= 1.36
#include "SerializationExportWrapperForCpp.hpp"
CHASTE_CLASS_EXPORT(BiasedBernoulliTrialCellCycleModel)