CryptCentreBasedDivisionRule.cpp

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*/
 
#include "CryptCentreBasedDivisionRule.hpp"
#include "RandomNumberGenerator.hpp"
#include "Exception.hpp"
 
template<unsigned ELEMENT_DIM, unsigned SPACE_DIM>
std::pair<c_vector<double, SPACE_DIM>, c_vector<double, SPACE_DIM> > CryptCentreBasedDivisionRule<ELEMENT_DIM, SPACE_DIM>::CalculateCellDivisionVector(
    CellPtr pParentCell,
    AbstractCentreBasedCellPopulation<ELEMENT_DIM, SPACE_DIM>& rCellPopulation)
{
    // Get separation parameter
    double separation = rCellPopulation.GetMeinekeDivisionSeparation();
 
    // Make a random direction vector of the required length
    c_vector<double, SPACE_DIM> random_vector;
 
    c_vector<double, SPACE_DIM> parent_coords;
    parent_coords = rCellPopulation.GetLocationOfCellCentre(pParentCell);
 
    c_vector<double, SPACE_DIM> daughter_coords;
 
    switch (SPACE_DIM)
    {
        case 1:
        {
            double random_direction = -1.0 + 2.0*(RandomNumberGenerator::Instance()->ranf() < 0.5);
            random_vector(0) = 0.5*separation*random_direction;
            c_vector<double, SPACE_DIM> proposed_new_parent_coords;
            //proposed_new_parent_coords = parent_coords - random_vector;
            proposed_new_parent_coords(0) = parent_coords(0) - random_vector(0);
            c_vector<double, SPACE_DIM> proposed_new_daughter_coords = zero_vector<double>(SPACE_DIM);
            proposed_new_daughter_coords = parent_coords + random_vector;
 
            if ((proposed_new_parent_coords(0) >= 0.0) && (proposed_new_daughter_coords(0) >= 0.0))
            {
                // We are not too close to the bottom of the cell population, so move parent
                parent_coords = proposed_new_parent_coords;
                daughter_coords = proposed_new_daughter_coords;
            }
            else
            {
                proposed_new_daughter_coords = parent_coords + 2.0*random_vector;
                while (proposed_new_daughter_coords(0) < 0.0)
                {
                    double fresh_random_direction = -1.0 + 2.0*(RandomNumberGenerator::Instance()->ranf() < 0.5);
                    random_vector(0) = 0.5*separation*fresh_random_direction;
                    proposed_new_daughter_coords = parent_coords + random_vector;
                }
                daughter_coords = proposed_new_daughter_coords;
            }
 
            // To make sure that dividing cells stay in the cell population
            assert(daughter_coords(0) >= 0.0);
            assert(parent_coords(0) >= 0.0);
 
            break;
        }
        case 2:
        {
            /*
             * Pick a random direction and move the parent cell backwards by 0.5*separation
             * in that direction and return the position of the daughter cell 0.5*separation
             * forwards in that direction.
             */
            double random_angle = RandomNumberGenerator::Instance()->ranf();
            random_angle *= 2.0*M_PI;
 
            random_vector(0) = 0.5*separation*cos(random_angle);
            random_vector(1) = 0.5*separation*sin(random_angle);
 
            c_vector<double, SPACE_DIM> proposed_new_parent_coords = zero_vector<double>(SPACE_DIM);
            proposed_new_parent_coords = parent_coords - random_vector;
            c_vector<double, SPACE_DIM> proposed_new_daughter_coords;
            proposed_new_daughter_coords = parent_coords + random_vector;
 
            if ((proposed_new_parent_coords(1) >= 0.0) && (proposed_new_daughter_coords(1) >= 0.0))
            {
                // We are not too close to the bottom of the cell population, so move parent
                parent_coords = proposed_new_parent_coords;
                daughter_coords = proposed_new_daughter_coords;
            }
            else
            {
                proposed_new_daughter_coords = parent_coords + 2.0*random_vector;
                while (proposed_new_daughter_coords(1) < 0.0)
                {
                    random_angle = RandomNumberGenerator::Instance()->ranf();
                    random_angle *= 2.0*M_PI;
 
                    random_vector(0) = separation*cos(random_angle);
                    random_vector(1) = separation*sin(random_angle);
                    proposed_new_daughter_coords = parent_coords + random_vector;
                }
                daughter_coords = proposed_new_daughter_coords;
            }
 
            // To make sure that dividing cells stay in the cell population
            assert(daughter_coords(1) >= 0.0);
            assert(parent_coords(1) >= 0.0);
            break;
        }
        case 3:
        {
            EXCEPTION("CryptCentreBasedDivisionRule is not implemented for SPACE_DIM == 3");
            break;
        }
        default:
            // This can't happen
            NEVER_REACHED;
    }
 
    std::pair<c_vector<double, SPACE_DIM>, c_vector<double, SPACE_DIM> > positions(parent_coords, daughter_coords);
    return positions;
}
 
// Explicit instantiation
template class CryptCentreBasedDivisionRule<1,1>;
template class CryptCentreBasedDivisionRule<1,2>;
template class CryptCentreBasedDivisionRule<2,2>;
template class CryptCentreBasedDivisionRule<1,3>;
template class CryptCentreBasedDivisionRule<2,3>;
template class CryptCentreBasedDivisionRule<3,3>;
 
// Serialization for Boost >= 1.36
#include "SerializationExportWrapperForCpp.hpp"
EXPORT_TEMPLATE_CLASS_ALL_DIMS(CryptCentreBasedDivisionRule)