SimpleWntCellCycleModel Class Reference

#include <SimpleWntCellCycleModel.hpp>

Inherited by SingleOdeWntCellCycleModel.

Collaboration diagram for SimpleWntCellCycleModel:

Public Member Functions
	SimpleWntCellCycleModel ()
virtual void	UpdateCellCyclePhase ()
virtual void	InitialiseDaughterCell ()
virtual AbstractCellCycleModel *	CreateCellCycleModel ()
void	SetUseCellProliferativeTypeDependentG1Duration (bool useCellProliferativeTypeDependentG1Duration=true)
virtual bool	CanCellTerminallyDifferentiate ()
Protected Member Functions
double	GetWntLevel ()
WntConcentrationType	GetWntType ()
void	SetG1Duration ()
Private Member Functions
template<class Archive >
void	serialize (Archive &archive, const unsigned int version)
Private Attributes
bool	mUseCellProliferativeTypeDependentG1Duration
Friends
class	boost::serialization::access

Detailed Description

Simple Wnt-dependent cell cycle model

Definition at line 46 of file SimpleWntCellCycleModel.hpp.

Constructor & Destructor Documentation

SimpleWntCellCycleModel::SimpleWntCellCycleModel ( )

Constructor - just a default, mBirthTime is now set in the AbstractCellCycleModel class. mG1Duration is set very high, it is set for the individual cells when InitialiseDaughterCell is called.

Definition at line 30 of file SimpleWntCellCycleModel.cpp.

Referenced by CreateCellCycleModel().

Member Function Documentation

bool SimpleWntCellCycleModel::CanCellTerminallyDifferentiate ( ) [virtual]

Overridden CanCellTerminallyDifferentiate() method.

Reimplemented from AbstractCellCycleModel.

Definition at line 223 of file SimpleWntCellCycleModel.cpp.

AbstractCellCycleModel * SimpleWntCellCycleModel::CreateCellCycleModel ( ) [virtual]

Overridden builder method to create new copies of this cell cycle model.

Implements AbstractCellCycleModel.

Reimplemented in SingleOdeWntCellCycleModel.

Definition at line 36 of file SimpleWntCellCycleModel.cpp.

References SimpleWntCellCycleModel().

double SimpleWntCellCycleModel::GetWntLevel ( ) [protected]

Get the Wnt level experienced by the cell.

Definition at line 86 of file SimpleWntCellCycleModel.cpp.

References AbstractCellCycleModel::mDimension, and AbstractCellCycleModel::mpCell.

Referenced by SingleOdeWntCellCycleModel::Initialise(), SingleOdeWntCellCycleModel::UpdateBetaCateninLevel(), and UpdateCellCyclePhase().

WntConcentrationType SimpleWntCellCycleModel::GetWntType ( ) [protected]

Get the type of Wnt concentration (LINEAR, RADIAL, or NONE). This affects how the cell cycle phase is updated.

Definition at line 118 of file SimpleWntCellCycleModel.cpp.

References AbstractCellCycleModel::mDimension.

Referenced by InitialiseDaughterCell(), and UpdateCellCyclePhase().

void SimpleWntCellCycleModel::InitialiseDaughterCell ( ) [virtual]

Overridden InitialiseDaughterCell() method.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 211 of file SimpleWntCellCycleModel.cpp.

References GetWntType(), AbstractCellCycleModel::mpCell, and TissueCell::SetCellProliferativeType().

template<class Archive >

void SimpleWntCellCycleModel::serialize	(	Archive &	archive,
		const unsigned int	version
	)			`[inline, private]`

Archive the cell cycle model, never used directly - boost uses this.

Parameters:

	archive	the archive
	version	the current version of this class

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 59 of file SimpleWntCellCycleModel.hpp.

References RandomNumberGenerator::Instance(), and mUseCellProliferativeTypeDependentG1Duration.

void SimpleWntCellCycleModel::SetG1Duration ( ) [protected, virtual]

Stochastically set the G1 duration. The G1 duration is taken from a normal distribution whose mean is the G1 duration given in TissueConfig for the cell type and whose standard deviation is 1.

Called on cell creation at the start of a simulation, and for both parent and daughter cells at cell division.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 48 of file SimpleWntCellCycleModel.cpp.

References TissueCell::GetCellProliferativeType(), TissueConfig::GetMinimumGapDuration(), TissueConfig::GetStemCellG1Duration(), TissueConfig::GetTransitCellG1Duration(), RandomNumberGenerator::Instance(), TissueConfig::Instance(), AbstractCellCycleModel::mG1Duration, AbstractCellCycleModel::mpCell, mUseCellProliferativeTypeDependentG1Duration, and RandomNumberGenerator::NormalRandomDeviate().