VanLeeuwen2009WntSwatCellCycleOdeSystem Class Reference

#include <VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp>

Collaboration diagram for VanLeeuwen2009WntSwatCellCycleOdeSystem:

Public Member Functions
	VanLeeuwen2009WntSwatCellCycleOdeSystem (unsigned hypothesis, double wntLevel=0.0, boost::shared_ptr< AbstractCellMutationState > pMutationState=boost::shared_ptr< AbstractCellMutationState >(), std::vector< double > stateVariables=std::vector< double >())
	~VanLeeuwen2009WntSwatCellCycleOdeSystem ()
void	Init ()
void	SetMutationState (boost::shared_ptr< AbstractCellMutationState > pMutationState)
const boost::shared_ptr < AbstractCellMutationState >	GetMutationState () const
void	EvaluateYDerivatives (double time, const std::vector< double > &rY, std::vector< double > &rDY)
bool	CalculateStoppingEvent (double time, const std::vector< double > &rY)
double	CalculateRootFunction (double time, const std::vector< double > &rY)
double	GetWntLevel () const
unsigned	GetHypothesis () const
Private Member Functions
template<class Archive >
void	serialize (Archive &archive, const unsigned int version)
Private Attributes
double	mk2d
double	mk3d
double	mk34d
double	mk43d
double	mk23d
double	mad
double	mJ11d
double	mJ12d
double	mJ13d
double	mJ61d
double	mJ62d
double	mJ63d
double	mKm1d
double	mkpd
double	mphi_r
double	mphi_i
double	mphi_j
double	mphi_p
double	mk16d
double	mk61d
double	mPhiE2F1
double	mSa
double	mSca
double	mSc
double	mSct
double	mSd
double	mSt
double	mSx
double	mSy
double	mDa
double	mDca
double	mDc
double	mDct
double	mDd
double	mDdx
double	mDt
double	mDu
double	mDx
double	mDy
double	mKc
double	mKd
double	mKt
double	mPc
double	mPu
double	mXiD
double	mXiDx
double	mXiX
double	mXiC
boost::shared_ptr < AbstractCellMutationState >	mpMutationState
unsigned	mHypothesis
double	mWntLevel
Friends
class	boost::serialization::access

Detailed Description

Represents the van Leeuwen et al. (2007) system of ODEs [doi:10.1016/j.jtbi.2007.01.019] coupled to the Swat et al. cell-cycle model equations. [doi:10.1093/bioinformatics/bth110]

The variables are

0. r = pRb 1. e = E2F1 (This is the S-phase indicator) 2. i = CycD (inactive) 3. j = CycD (active) 4. p = pRb-p 5. D = APC destruction complex 6. X = Axin 7. Cu = Beta Cat marked for ubiquitination 8. Co = Open form Beta Cat 9. Cc = Closed form Beta Cat 10. Mo = Open form Mutant Beta Cat 11. Mc = Closed form Mutant Beta Cat 12. A = Free Adhesion molecules 13. Ca = BetaCat/Adhesion 14. Ma = Mutant BetaCat/Adhesion 15. T = free TCF 16. Cot = Open BetaCat/TCF 17. Cct = Closed BetaCat/TCF 18. Mot = Open Mutant BetaCat/TCF 19. Mct = Closed Mutant BetaCat/TCF 20. Y = Wnt Target protein 21. Wnt level

Definition at line 80 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Constructor & Destructor Documentation

VanLeeuwen2009WntSwatCellCycleOdeSystem::VanLeeuwen2009WntSwatCellCycleOdeSystem	(	unsigned	hypothesis,
		double	wntLevel = `0.0`,
		boost::shared_ptr< AbstractCellMutationState >	pMutationState = `boost::shared_ptr<AbstractCellMutationState>()`,
		std::vector< double >	stateVariables = `std::vector<double>()`
	)

Constructor.

Parameters:

	hypothesis	takes the value 1 or 2 and affects the ODE system.
	wntLevel	is a non-dimensional Wnt value between 0 and 1. This sets up the Wnt pathway in its steady state.
	pMutationState	cell mutation; some affect the ODE system
	stateVariables	optional initial conditions for state variables (only used in archiving)

State variables are

0. r = pRb 1. e = E2F1 (This is the S-phase indicator) 2. i = CycD (inactive) 3. j = CycD (active) 4. p = pRb-p 5. D = APC destruction complex 6. X = Axin 7. Cu = Beta Cat marked for ubiquitination 8. Co = Open form Beta Cat 9. Cc = Closed form Beta Cat 10. Mo = Open form Mutant Beta Cat 11. Mc = Closed form Mutant Beta Cat 12. A = Free Adhesion molecules 13. Ca = BetaCat/Adhesion 14. Ma = Mutant BetaCat/Adhesion 15. T = free TCF 16. Cot = Open BetaCat/TCF 17. Cct = Closed BetaCat/TCF 18. Mot = Open Mutant BetaCat/TCF 19. Mct = Closed Mutant BetaCat/TCF 20. Y = Wnt Target protein 21. Wnt level

Definition at line 32 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.cpp.

References EXCEPTION, Init(), mDa, mDc, mDca, mDct, mDd, mDdx, mDt, mDu, mDx, mDy, mKc, mKd, mKt, mPc, mpMutationState, AbstractUntemplatedParameterisedSystem::mpSystemInfo, mPu, mSa, mSc, mSca, mSct, mSd, mSt, mSx, mSy, mXiC, mXiD, mXiDx, mXiX, AbstractParameterisedSystem< std::vector< double > >::SetDefaultInitialCondition(), and AbstractParameterisedSystem< std::vector< double > >::SetStateVariables().

VanLeeuwen2009WntSwatCellCycleOdeSystem::~VanLeeuwen2009WntSwatCellCycleOdeSystem ( )

Destructor.

Definition at line 152 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.cpp.

Member Function Documentation

double VanLeeuwen2009WntSwatCellCycleOdeSystem::CalculateRootFunction	(	double	time,
		const std::vector< double > &	rY
	)			`[virtual]`

When using CVODE this function is called instead of CalculateStoppingEvent. It allows the point at which rY[1] reaches 1 to be found to greater precision.

Parameters:

	time	at which to calculate whether the stopping event has occurred
	rY	value of the solution vector used to evaluate the RHS

Returns:: How close we are to the root of the stopping condition

Reimplemented from AbstractOdeSystem.

Definition at line 376 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.cpp.

bool VanLeeuwen2009WntSwatCellCycleOdeSystem::CalculateStoppingEvent	(	double	time,
		const std::vector< double > &	rY
	)			`[virtual]`

Calculate whether the conditions for the cell cycle to finish have been met.

Parameters:

	time	at which to calculate whether the stopping event has occurred
	rY	value of the solution vector used to evaluate the RHS

Returns:: whether or not stopping conditions have been met

Reimplemented from AbstractOdeSystem.

Definition at line 368 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.cpp.

References EvaluateYDerivatives().

void VanLeeuwen2009WntSwatCellCycleOdeSystem::EvaluateYDerivatives	(	double	time,
		const std::vector< double > &	rY,
		std::vector< double > &	rDY
	)			`[virtual]`

Compute the RHS of the system of ODEs.

Returns a vector representing the RHS of the ODEs at each time step, y' = [y1' ... yn']. An ODE solver will call this function repeatedly to solve for y = [y1 ... yn].

Parameters:

	time	used to evaluate the RHS.
	rY	value of the solution vector used to evaluate the RHS.
	rDY	filled in with the resulting derivatives (using van Leeuwen et al. (2007) system of equations)

Implements AbstractOdeSystem.

Definition at line 248 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.cpp.

References mad, mDa, mDc, mDca, mDct, mDd, mDdx, mDt, mDu, mDx, mDy, mJ11d, mJ12d, mJ13d, mJ61d, mJ62d, mJ63d, mk16d, mk23d, mk2d, mk34d, mk3d, mk43d, mk61d, mKc, mKd, mKm1d, mkpd, mKt, mPc, mphi_i, mphi_j, mphi_p, mphi_r, mPhiE2F1, mpMutationState, mPu, mSa, mSc, mSca, mSct, mSd, mSt, mSx, mSy, mXiC, mXiD, mXiDx, and mXiX.

Referenced by CalculateStoppingEvent().

unsigned VanLeeuwen2009WntSwatCellCycleOdeSystem::GetHypothesis ( ) const

Get method for mHypothesis.

Definition at line 480 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.cpp.

References mHypothesis.

const boost::shared_ptr< AbstractCellMutationState > VanLeeuwen2009WntSwatCellCycleOdeSystem::GetMutationState ( ) const

Called by the archive function on the Wnt cell-cycle model.

Returns:: mpMutationState the mutation state of the cell.

Definition at line 363 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.cpp.

References mpMutationState.

double VanLeeuwen2009WntSwatCellCycleOdeSystem::GetWntLevel ( ) const

Get method for mWntLevel.

Definition at line 475 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.cpp.

References mWntLevel.

void VanLeeuwen2009WntSwatCellCycleOdeSystem::Init ( )

Initialise parameter values.

Definition at line 157 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.cpp.

References mad, mDa, mDc, mDca, mDct, mDd, mDdx, mDt, mDu, mDx, mDy, mHypothesis, mJ11d, mJ12d, mJ13d, mJ61d, mJ62d, mJ63d, mk16d, mk23d, mk2d, mk34d, mk3d, mk43d, mk61d, mKc, mKd, mKm1d, mkpd, mKt, mPc, mphi_i, mphi_j, mphi_p, mphi_r, mPhiE2F1, mPu, mSa, mSc, mSca, mSct, mSd, mSt, mSx, mSy, mXiC, mXiD, mXiDx, and mXiX.

Referenced by VanLeeuwen2009WntSwatCellCycleOdeSystem().

template<class Archive >

void VanLeeuwen2009WntSwatCellCycleOdeSystem::serialize	(	Archive &	archive,
		const unsigned int	version
	)			`[inline, private]`

Serialize the object and its member variables.

Parameters:

	archive	the archive
	version	the current version of this class

Definition at line 211 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

void VanLeeuwen2009WntSwatCellCycleOdeSystem::SetMutationState ( boost::shared_ptr< AbstractCellMutationState > pMutationState )

Set the mutation state of the cell.

This should be called by the relevant cell-cycle model before any solving of the ODE system (as it is used to evaluate the Y derivatives).

Parameters:

pMutationState

the mutation state.

Definition at line 147 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.cpp.

References mpMutationState.

Member Data Documentation

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mad [private]

Dimensional parameter a.

Definition at line 99 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mDa [private]

Dimensionless parameter d_A.

Definition at line 152 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mDc [private]

Dimensionless parameter d_C.

Definition at line 156 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mDca [private]

Dimensionless parameter d_CA.

Definition at line 154 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mDct [private]

Dimensionless parameter d_CT.

Definition at line 158 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mDd [private]

Dimensionless parameter d_D.

Definition at line 160 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mDdx [private]

Dimensionless parameter d_Dx.

Definition at line 162 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mDt [private]

Dimensionless parameter d_T.

Definition at line 164 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mDu [private]

Dimensionless parameter d_U.

Definition at line 166 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mDx [private]

Dimensionless parameter d_X.

Definition at line 168 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mDy [private]

Dimensionless parameter d_Y.

Definition at line 170 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

unsigned VanLeeuwen2009WntSwatCellCycleOdeSystem::mHypothesis [private]

The hypothesis we are using = 1u for Van Leeuwen Hypothesis I = 2u for Van Leeuwen Hypothesis II

Definition at line 198 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by GetHypothesis(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mJ11d [private]

Dimensional parameter J_11.

Definition at line 101 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mJ12d [private]

Dimensional parameter J_12.

Definition at line 103 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mJ13d [private]

Dimensional parameter J_13.

Definition at line 105 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mJ61d [private]

Dimensional parameter J_13.

Definition at line 107 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mJ62d [private]

Dimensional parameter J_62.

Definition at line 109 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mJ63d [private]

Dimensional parameter J_63.

Definition at line 111 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mk16d [private]

Dimensional parameter k_16.

Definition at line 125 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mk23d [private]

Dimensional parameter k_23.

Definition at line 97 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mk2d [private]

Parameters for the Swat et al. (2004) model Dimensional parameter k_2.

Definition at line 89 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mk34d [private]

Dimensional parameter k_34.

Definition at line 93 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mk3d [private]

Dimensional parameter k_3.

Definition at line 91 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mk43d [private]

Dimensional parameter k_2.

Definition at line 95 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mk61d [private]

Dimensional parameter k_61.

Definition at line 127 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mKc [private]

Dimensionless parameter K_c.

Definition at line 172 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mKd [private]

Dimensionless parameter K_D.

Definition at line 174 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mKm1d [private]

Dimensional parameter K_m1.

Definition at line 113 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mkpd [private]

Dimensional parameter k_p.

Definition at line 115 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mKt [private]

Dimensionless parameter K_T.

Definition at line 176 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mPc [private]

Dimensionless parameter p_c.

Definition at line 178 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mphi_i [private]

Dimensionless parameter phi_i.

Definition at line 119 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mphi_j [private]

Dimensionless parameter phi_j.

Definition at line 121 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mphi_p [private]

Dimensionless parameter phi_p.

Definition at line 123 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mphi_r [private]

Dimensionless parameter phi_r.

Definition at line 117 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mPhiE2F1 [private]

Dimensionless parameter phi_E2F1.

Definition at line 129 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and Init().

boost::shared_ptr<AbstractCellMutationState> VanLeeuwen2009WntSwatCellCycleOdeSystem::mpMutationState [private]

The mutation state of the cell.

Definition at line 191 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), GetMutationState(), SetMutationState(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mPu [private]

Dimensionless parameter p_u.

Definition at line 180 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mSa [private]

Parameters for the Van Leeuwen et al. (2007) model Dimensionless parameter s_A.

Definition at line 136 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mSc [private]

Dimensionless parameter s_C.

Definition at line 140 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mSca [private]

Dimensionless parameter s_CA.

Definition at line 138 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mSct [private]

Dimensionless parameter s_CT.

Definition at line 142 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mSd [private]

Dimensionless parameter s_D.

Definition at line 144 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mSt [private]

Dimensionless parameter s_T.

Definition at line 146 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mSx [private]

Dimensionless parameter s_X.

Definition at line 148 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mSy [private]

Dimensionless parameter s_Y.

Definition at line 150 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mWntLevel [private]

The Wnt level (this affects the ODE system).

Definition at line 201 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by GetWntLevel().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mXiC [private]

Dimensionless parameter xi_C.

Definition at line 188 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mXiD [private]

Dimensionless parameter xi_D.

Definition at line 182 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mXiDx [private]

Dimensionless parameter xi_Dx.

Definition at line 184 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

double VanLeeuwen2009WntSwatCellCycleOdeSystem::mXiX [private]

Dimensionless parameter xi_X.

Definition at line 186 of file VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp.

Referenced by EvaluateYDerivatives(), Init(), and VanLeeuwen2009WntSwatCellCycleOdeSystem().

The documentation for this class was generated from the following files:

crypt/src/odes/VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp
crypt/src/odes/VanLeeuwen2009WntSwatCellCycleOdeSystem.cpp

VanLeeuwen2009WntSwatCellCycleOdeSystem Class Reference

Public Member Functions

Private Member Functions

Private Attributes

Friends

Detailed Description

Constructor & Destructor Documentation

Member Function Documentation

Member Data Documentation