#include <SimpleWntCellCycleModel.hpp>

Inheritance diagram for SimpleWntCellCycleModel:

Collaboration diagram for SimpleWntCellCycleModel:

Public Member Functions
	SimpleWntCellCycleModel ()
virtual void	UpdateCellCyclePhase ()
virtual void	InitialiseDaughterCell ()
virtual AbstractCellCycleModel *	CreateCellCycleModel ()
void	SetUseCellProliferativeTypeDependentG1Duration (bool useCellProliferativeTypeDependentG1Duration=true)
virtual bool	CanCellTerminallyDifferentiate ()
double	GetWntStemThreshold ()
void	SetWntStemThreshold (double wntStemThreshold)
double	GetWntTransitThreshold ()
void	SetWntTransitThreshold (double wntTransitThreshold)
double	GetWntLabelledThreshold ()
void	SetWntLabelledThreshold (double wntLabelledThreshold)
virtual void	OutputCellCycleModelParameters (out_stream &rParamsFile)
Protected Member Functions
double	GetWntLevel ()
WntConcentrationType	GetWntType ()
void	SetG1Duration ()
Protected Attributes
bool	mUseCellProliferativeTypeDependentG1Duration
double	mWntStemThreshold
double	mWntTransitThreshold
double	mWntLabelledThreshold
Private Member Functions
template<class Archive >
void	serialize (Archive &archive, const unsigned int version)
Friends
class	boost::serialization::access

Detailed Description

Simple Wnt-dependent cell-cycle model

Definition at line 54 of file SimpleWntCellCycleModel.hpp.

Constructor & Destructor Documentation

SimpleWntCellCycleModel::SimpleWntCellCycleModel ( )

Constructor - just a default, mBirthTime is now set in the AbstractCellCycleModel class. mG1Duration is set very high, it is set for the individual cells when InitialiseDaughterCell is called.

Definition at line 39 of file SimpleWntCellCycleModel.cpp.

Referenced by CreateCellCycleModel().

Member Function Documentation

bool SimpleWntCellCycleModel::CanCellTerminallyDifferentiate ( ) [virtual]

Overridden CanCellTerminallyDifferentiate() method.

Reimplemented from AbstractCellCycleModel.

Definition at line 252 of file SimpleWntCellCycleModel.cpp.

AbstractCellCycleModel * SimpleWntCellCycleModel::CreateCellCycleModel ( ) [virtual]

Overridden builder method to create new copies of this cell-cycle model.

Implements AbstractCellCycleModel.

Reimplemented in SingleOdeWntCellCycleModel.

Definition at line 47 of file SimpleWntCellCycleModel.cpp.

double SimpleWntCellCycleModel::GetWntLabelledThreshold ( )

Returns:: mWntLabelledThreshold

Definition at line 281 of file SimpleWntCellCycleModel.cpp.

References mWntLabelledThreshold.

double SimpleWntCellCycleModel::GetWntLevel ( ) [protected]

Get the Wnt level experienced by the cell.

Definition at line 121 of file SimpleWntCellCycleModel.cpp.

References WntConcentration< DIM >::GetWntLevel(), AbstractCellCycleModel::mDimension, AbstractCellCycleModel::mpCell, and NEVER_REACHED.

Referenced by SingleOdeWntCellCycleModel::AdjustOdeParameters(), SingleOdeWntCellCycleModel::CreateCellCycleModel(), SingleOdeWntCellCycleModel::Initialise(), and UpdateCellCyclePhase().

double SimpleWntCellCycleModel::GetWntStemThreshold ( )

Returns:: mWntStemThreshold

Definition at line 257 of file SimpleWntCellCycleModel.cpp.

References mWntStemThreshold.

double SimpleWntCellCycleModel::GetWntTransitThreshold ( )

Returns:: mWntTransitThreshold

Definition at line 269 of file SimpleWntCellCycleModel.cpp.

References mWntTransitThreshold.

WntConcentrationType SimpleWntCellCycleModel::GetWntType ( ) [protected]

Get the type of Wnt concentration (LINEAR, RADIAL, EXPONENTIAL or NONE). This affects how the cell cycle phase is updated.

Definition at line 152 of file SimpleWntCellCycleModel.cpp.

References WntConcentration< DIM >::GetType(), AbstractCellCycleModel::mDimension, and NEVER_REACHED.

Referenced by InitialiseDaughterCell(), and UpdateCellCyclePhase().

void SimpleWntCellCycleModel::InitialiseDaughterCell ( ) [virtual]

Overridden InitialiseDaughterCell() method.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 240 of file SimpleWntCellCycleModel.cpp.

References GetWntType(), and AbstractCellCycleModel::mpCell.

void SimpleWntCellCycleModel::OutputCellCycleModelParameters ( out_stream & rParamsFile ) [virtual]

Outputs cell-cycle model parameters to file.

Parameters:

rParamsFile the file stream to which the parameters are output

Reimplemented from AbstractSimpleCellCycleModel.

Reimplemented in SingleOdeWntCellCycleModel.

Definition at line 293 of file SimpleWntCellCycleModel.cpp.

References mUseCellProliferativeTypeDependentG1Duration, mWntLabelledThreshold, mWntStemThreshold, and mWntTransitThreshold.

template<class Archive >

void SimpleWntCellCycleModel::serialize	(	Archive &	archive,
		const unsigned int	version
	)		`[inline, private]`

Archive the cell-cycle model, never used directly - boost uses this.

Parameters:

archive	the archive
version	the current version of this class

Reimplemented from AbstractSimpleCellCycleModel.

Reimplemented in SingleOdeWntCellCycleModel.

Definition at line 67 of file SimpleWntCellCycleModel.hpp.

References RandomNumberGenerator::Instance(), mUseCellProliferativeTypeDependentG1Duration, mWntLabelledThreshold, mWntStemThreshold, and mWntTransitThreshold.

void SimpleWntCellCycleModel::SetG1Duration ( ) [protected, virtual]

Stochastically set the G1 duration. The G1 duration is taken from a normal distribution whose mean is the G1 duration given in AbstractCellCycleModel for the cell type and whose standard deviation is 1.

Called on cell creation at the start of a simulation, and for both parent and daughter cells at cell division.

Reimplemented from AbstractSimpleCellCycleModel.

Definition at line 85 of file SimpleWntCellCycleModel.cpp.

References AbstractCellCycleModel::GetStemCellG1Duration(), AbstractCellCycleModel::GetTransitCellG1Duration(), RandomNumberGenerator::Instance(), AbstractCellCycleModel::mG1Duration, AbstractCellCycleModel::mMinimumGapDuration, AbstractCellCycleModel::mpCell, mUseCellProliferativeTypeDependentG1Duration, NEVER_REACHED, and RandomNumberGenerator::NormalRandomDeviate().