Chaste Commit::ca8ccdedf819b6e02855bc0e8e6f50bdecbc5208
AbstractSimpleGenerationalCellCycleModel.cpp
1/*
2
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34*/
35
36#include "AbstractSimpleGenerationalCellCycleModel.hpp"
37#include "DifferentiatedCellProliferativeType.hpp"
38#include "StemCellProliferativeType.hpp"
39#include "TransitCellProliferativeType.hpp"
40
43 mGeneration(0),
44 mMaxTransitGenerations(3) // taken from Meineke et al, 2001 (doi:10.1046/j.0960-7722.2001.00216.x)
45{
46}
47
51
54 mGeneration(rModel.mGeneration),
55 mMaxTransitGenerations(rModel.mMaxTransitGenerations)
56{
57 /*
58 * Initialize only those member variables defined in this class.
59 *
60 * The member variables mCurrentCellCyclePhase, mG1Duration,
61 * mMinimumGapDuration, mStemCellG1Duration, mTransitCellG1Duration,
62 * mSDuration, mG2Duration and mMDuration are initialized in the
63 * AbstractPhaseBasedCellCycleModel constructor.
64 *
65 * The member variables mBirthTime, mReadyToDivide and mDimension
66 * are initialized in the AbstractCellCycleModel constructor.
67 *
68 * Note that mG1Duration is (re)set as soon as InitialiseDaughterCell()
69 * is called on the new cell-cycle model.
70 */
71}
72
74{
76 if (mpCell->GetCellProliferativeType()->IsType<StemCellProliferativeType>())
77 {
78 /*
79 * Run this check first to allow for mMaxTransitGenerations = 0
80 */
81 mGeneration = 0;
82 }
84 {
85 /*
86 * This method is usually called within a CellBasedSimulation, after the CellPopulation
87 * has called CellPropertyRegistry::TakeOwnership(). This means that were we to call
88 * CellPropertyRegistry::Instance() here when setting the CellProliferativeType, we
89 * would be creating a new CellPropertyRegistry. In this case the cell proliferative
90 * type counts, as returned by AbstractCellPopulation::GetCellProliferativeTypeCount(),
91 * would be incorrect. We must therefore access the CellProliferativeType via the cell's
92 * CellPropertyCollection.
93 */
94 boost::shared_ptr<AbstractCellProperty> p_diff_type =
95 mpCell->rGetCellPropertyCollection().GetCellPropertyRegistry()->Get<DifferentiatedCellProliferativeType>();
96 mpCell->SetCellProliferativeType(p_diff_type);
97 }
99}
100
102{
103 /*
104 * If the parent cell is a stem cell then its generation was reset
105 * to zero when ResetForDivision() was called. The daughter cell's
106 * generation must therefore be incremented here.
107 */
108 if (mGeneration == 0)
109 {
110 mGeneration = 1;
111 }
112 /*
113 * In generation-based cell-cycle models, the daughter cell
114 * is always of type transit or differentiated.
115 */
116 boost::shared_ptr<AbstractCellProperty> p_transit_type =
117 mpCell->rGetCellPropertyCollection().GetCellPropertyRegistry()->Get<TransitCellProliferativeType>();
118 mpCell->SetCellProliferativeType(p_transit_type);
119
121 {
122 boost::shared_ptr<AbstractCellProperty> p_diff_type =
123 mpCell->rGetCellPropertyCollection().GetCellPropertyRegistry()->Get<DifferentiatedCellProliferativeType>();
124 mpCell->SetCellProliferativeType(p_diff_type);
125 }
127}
128
130{
131 mGeneration = generation;
132}
133
138
140{
141 mMaxTransitGenerations = maxTransitGenerations;
142}
143
148
150{
151 *rParamsFile << "\t\t\t<MaxTransitGenerations>" << mMaxTransitGenerations << "</MaxTransitGenerations>\n";
152
153 // Call method on direct parent class
155}
virtual void OutputCellCycleModelParameters(out_stream &rParamsFile)