AbstractSimplePhaseBasedCellCycleModel.cpp

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#include "AbstractSimplePhaseBasedCellCycleModel.hpp"
#include "StemCellProliferativeType.hpp"
#include "TransitCellProliferativeType.hpp"
#include "DifferentiatedCellProliferativeType.hpp"
 
AbstractSimplePhaseBasedCellCycleModel::AbstractSimplePhaseBasedCellCycleModel()
{
}
 
AbstractSimplePhaseBasedCellCycleModel::~AbstractSimplePhaseBasedCellCycleModel()
{
}
 
AbstractSimplePhaseBasedCellCycleModel::AbstractSimplePhaseBasedCellCycleModel(const AbstractSimplePhaseBasedCellCycleModel& rModel)
    : AbstractPhaseBasedCellCycleModel(rModel)
{
    /*
     * The member variables mCurrentCellCyclePhase, mG1Duration,
     * mMinimumGapDuration, mStemCellG1Duration, mTransitCellG1Duration,
     * mSDuration, mG2Duration and mMDuration are initialized in the
     * AbstractPhaseBasedCellCycleModel constructor.
     *
     * The member variables mBirthTime, mReadyToDivide and mDimension
     * are initialized in the AbstractCellCycleModel constructor.
     *
     * Note that mG1Duration is (re)set as soon as InitialiseDaughterCell()
     * is called on the new cell-cycle model.
     */
}
 
void AbstractSimplePhaseBasedCellCycleModel::Initialise()
{
    SetG1Duration();
}
 
void AbstractSimplePhaseBasedCellCycleModel::InitialiseDaughterCell()
{
    AbstractPhaseBasedCellCycleModel::InitialiseDaughterCell();
    SetG1Duration();
}
 
void AbstractSimplePhaseBasedCellCycleModel::SetG1Duration()
{
    assert(mpCell != nullptr);
 
    if (mpCell->GetCellProliferativeType()->IsType<StemCellProliferativeType>())
    {
        mG1Duration = GetStemCellG1Duration();
    }
    else if (mpCell->GetCellProliferativeType()->IsType<TransitCellProliferativeType>())
    {
        mG1Duration = GetTransitCellG1Duration();
    }
    else if (mpCell->GetCellProliferativeType()->IsType<DifferentiatedCellProliferativeType>())
    {
        mG1Duration = DBL_MAX;
    }
    else
    {
        NEVER_REACHED;
    }
}
 
void AbstractSimplePhaseBasedCellCycleModel::ResetForDivision()
{
    AbstractPhaseBasedCellCycleModel::ResetForDivision();
    SetG1Duration();
}
 
void AbstractSimplePhaseBasedCellCycleModel::UpdateCellCyclePhase()
{
    double time_since_birth = GetAge();
    assert(time_since_birth >= 0);
 
    if (mpCell->GetCellProliferativeType()->IsType<DifferentiatedCellProliferativeType>())
    {
        mCurrentCellCyclePhase = G_ZERO_PHASE;
    }
    else if (time_since_birth < GetMDuration())
    {
        mCurrentCellCyclePhase = M_PHASE;
    }
    else if (time_since_birth < GetMDuration() + mG1Duration)
    {
        mCurrentCellCyclePhase = G_ONE_PHASE;
    }
    else if (time_since_birth < GetMDuration() + mG1Duration + GetSDuration())
    {
        mCurrentCellCyclePhase = S_PHASE;
    }
    else if (time_since_birth < GetMDuration() + mG1Duration + GetSDuration() + GetG2Duration())
    {
        mCurrentCellCyclePhase = G_TWO_PHASE;
    }
}
 
void AbstractSimplePhaseBasedCellCycleModel::OutputCellCycleModelParameters(out_stream& rParamsFile)
{
    // No new parameters to output, so just call method on direct parent class
    AbstractPhaseBasedCellCycleModel::OutputCellCycleModelParameters(rParamsFile);
}