Chaste Commit::ca8ccdedf819b6e02855bc0e8e6f50bdecbc5208
DeltaNotchEdgeOdeSystem.cpp
1/*
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34*/
35
36#include "CellwiseOdeSystemInformation.hpp"
37#include "DeltaNotchEdgeOdeSystem.hpp"
38
39DeltaNotchEdgeOdeSystem::DeltaNotchEdgeOdeSystem(std::vector<double> stateVariables)
41{
43
54 SetDefaultInitialCondition(0, 1.0); // soon overwritten
55 SetDefaultInitialCondition(1, 1.0); // soon overwritten
56
57 this->mParameters.push_back(0.5);
58 //By default zero. If no interior SRN model is specified, interior delta/notch is zero
59 this->mParameters.push_back(0.0);
60 this->mParameters.push_back(0.0);
61 if (stateVariables != std::vector<double>())
62 {
63 SetStateVariables(stateVariables);
64 }
65}
66
70
71void DeltaNotchEdgeOdeSystem::EvaluateYDerivatives(double time, const std::vector<double>& rY, std::vector<double>& rDY)
72{
73 const double notch = rY[0];
74 const double delta = rY[1];
75 const double neigh_delta = this->mParameters[0]; // Shorthand for "this->mParameter("neighbor delta");"
76 const double interior_delta = this->mParameters[1];
77 const double interior_notch = this->mParameters[2];
78 // The next two lines define the ODE system by Collier et al. (1996), except that we use neighbour Delta directly
79 //That is, neighbour activates notch, which can be degraded and trafficked from cytoplasm to this edge
80 rDY[0] = neigh_delta*neigh_delta/(0.01 + neigh_delta*neigh_delta) - notch+0.1*interior_notch; // d[Notch]/dt
81 // Delta is inhibited by notch in this this
82 rDY[1] = 1.0/(1.0 + 100.0*notch*notch) - delta+0.1*interior_delta;// d[Delta]/dt
83}
84
85template<>
87{
88 this->mVariableNames.push_back("Notch");
89 this->mVariableUnits.push_back("non-dim");
90 this->mInitialConditions.push_back(0.0); // will be filled in later
91
92 this->mVariableNames.push_back("Delta");
93 this->mVariableUnits.push_back("non-dim");
94 this->mInitialConditions.push_back(0.0); // will be filled in later
95
96 this->mParameterNames.push_back("neighbour delta");
97 this->mParameterUnits.push_back("non-dim");
98 this->mParameterNames.push_back("interior delta");
99 this->mParameterUnits.push_back("non-dim");
100 this->mParameterNames.push_back("interior notch");
101 this->mParameterUnits.push_back("non-dim");
102 this->mInitialised = true;
103}
104
105// Serialization for Boost >= 1.36
#define CHASTE_CLASS_EXPORT(T)
void SetStateVariables(const std::vector< double > &rStateVariables)
void SetDefaultInitialCondition(unsigned index, double initialCondition)
boost::shared_ptr< AbstractOdeSystemInformation > mpSystemInfo
void EvaluateYDerivatives(double time, const std::vector< double > &rY, std::vector< double > &rDY)
DeltaNotchEdgeOdeSystem(std::vector< double > stateVariables=std::vector< double >())