#include <CorriasBuistSMCModified.hpp>

Inheritance diagram for CorriasBuistSMCModified:

Collaboration diagram for CorriasBuistSMCModified:

Public Member Functions
	CorriasBuistSMCModified (boost::shared_ptr< AbstractIvpOdeSolver > pSolver, boost::shared_ptr< AbstractStimulusFunction > pIntracellularStimulus)
	~CorriasBuistSMCModified ()
void	VerifyStateVariables ()
double	GetIIonic (const std::vector< double > *pStateVariables=NULL)
void	EvaluateYDerivatives (double time, const std::vector< double > &rY, std::vector< double > &rDY)
void	SetFakeIccStimulusPresent (bool present)
bool	GetFakeIccStimulusPresent ()
double	SetCarbonMonoxideScaleFactor ()
void	SetCarbonMonoxideScaleFactor (double scaleFactor)
double	GetCarbonMonoxideScaleFactor ()
Private Member Functions
template<class Archive >
void	serialize (Archive &archive, const unsigned int version)
Private Attributes
double	mScaleFactorCarbonMonoxide
bool	mFakeIccStimulusPresent
double	Cm
double	Asurf_in_cm_square
double	Asurf
double	VolCell
double	hCa
double	sCa
double	Ki
double	Nai
double	ACh
double	CaiRest
double	gLVA_max
double	gCaL_max
double	gBK_max
double	gKb_max
double	gKA_max
double	gKr_max
double	gNa_max
double	gnsCC_max
double	gcouple
double	JCaExt_max
double	Q10Ca
double	Q10K
double	Q10Na
double	Texp
double	T_correct_Ca
double	T_correct_K
double	T_correct_Na
double	T_correct_gBK
double	EK
double	ENa
double	EnsCC
double	Ca_o
double	K_o
double	Na_o
double	R
double	T
double	F
double	FoRT
double	RToF
Friends
class	boost::serialization::access

Detailed Description

This class is a modified version of the model of a gastric Smooth Muscle Cell.

Reference publication is:

Corrias A, Buist ML. "A quantitative model of gastric smooth muscle cellular activation." Ann Biomed Eng. 2007 Sep;35(9):1595-607. Epub 2007 May 8.

Modifications include:

ability to include/exclude built-in fake ICC stimulus
ability to set K+ channels-affecting CO concentrations

Definition at line 58 of file CorriasBuistSMCModified.hpp.

Constructor & Destructor Documentation

CorriasBuistSMCModified::CorriasBuistSMCModified	(	boost::shared_ptr< AbstractIvpOdeSolver >	pSolver,
		boost::shared_ptr< AbstractStimulusFunction >	pIntracellularStimulus
	)

Constructor

Parameters:

pSolver	is a pointer to the ODE solver
pIntracellularStimulus	is a pointer to the intracellular stimulus

Definition at line 46 of file CorriasBuistSMCModified.cpp.

References ACh, Asurf, Asurf_in_cm_square, Ca_o, CaiRest, Cm, EK, ENa, EnsCC, F, FoRT, gBK_max, gCaL_max, gcouple, HeartConfig::GetCapacitance(), gKA_max, gKb_max, gKr_max, gLVA_max, gNa_max, gnsCC_max, hCa, AbstractCardiacCell::Init(), HeartConfig::Instance(), JCaExt_max, K_o, Ki, mFakeIccStimulusPresent, AbstractUntemplatedParameterisedSystem::mpSystemInfo, mScaleFactorCarbonMonoxide, Na_o, Nai, Q10Ca, Q10K, Q10Na, R, RToF, sCa, T, T_correct_Ca, T_correct_gBK, T_correct_K, T_correct_Na, Texp, and VolCell.

CorriasBuistSMCModified::~CorriasBuistSMCModified ( )

Destructor

Definition at line 117 of file CorriasBuistSMCModified.cpp.

Member Function Documentation

void CorriasBuistSMCModified::EvaluateYDerivatives	(	double	time,
		const std::vector< double > &	rY,
		std::vector< double > &	rDY
	)		`[virtual]`

Compute the RHS of the FitHugh-Nagumo system of ODEs

Parameters:

time	the current time, in milliseconds
rY	current values of the state variables
rDY	to be filled in with derivatives

Implements AbstractOdeSystem.

Definition at line 191 of file CorriasBuistSMCModified.cpp.

References ACh, Asurf, Ca_o, CaiRest, EK, ENa, EnsCC, F, gCaL_max, gcouple, AbstractCardiacCellInterface::GetStimulus(), gKA_max, gKb_max, gKr_max, gLVA_max, gNa_max, gnsCC_max, hCa, JCaExt_max, mFakeIccStimulusPresent, mScaleFactorCarbonMonoxide, AbstractCardiacCellInterface::mSetVoltageDerivativeToZero, RToF, sCa, T_correct_Ca, T_correct_gBK, T_correct_K, T_correct_Na, and VolCell.

double CorriasBuistSMCModified::GetCarbonMonoxideScaleFactor ( )

Returns the Carbon Monoxide scale factor

Definition at line 139 of file CorriasBuistSMCModified.cpp.

References mScaleFactorCarbonMonoxide.

bool CorriasBuistSMCModified::GetFakeIccStimulusPresent ( )

Return true if the fake ICC stimulus is present

Definition at line 134 of file CorriasBuistSMCModified.cpp.

References mFakeIccStimulusPresent.

double CorriasBuistSMCModified::GetIIonic ( const std::vector< double > * pStateVariables = NULL ) [virtual]

Calculates the ionic current

Parameters:

pStateVariables the state variables of this model

Returns:: the total ionic current

Now convert to microA over cm^2, the units that Chaste needs

Implements AbstractCardiacCellInterface.

Definition at line 144 of file CorriasBuistSMCModified.cpp.

References ACh, Asurf, Ca_o, EK, ENa, EnsCC, F, gCaL_max, gKA_max, gKb_max, gKr_max, gLVA_max, gNa_max, gnsCC_max, JCaExt_max, mScaleFactorCarbonMonoxide, AbstractParameterisedSystem< std::vector< double > >::rGetStateVariables(), RToF, T_correct_gBK, and VolCell.

template<class Archive >

void CorriasBuistSMCModified::serialize	(	Archive &	archive,
		const unsigned int	version
	)		`[inline, private]`

Archive the member variables.

Parameters:

archive
version

Reimplemented from AbstractCardiacCell.

Definition at line 62 of file CorriasBuistSMCModified.hpp.

double CorriasBuistSMCModified::SetCarbonMonoxideScaleFactor ( )

Returns the Carbon Monoxide scale for

void CorriasBuistSMCModified::SetCarbonMonoxideScaleFactor ( double scaleFactor )

Set the carbon monoxide scale factor. This will multiply the following currents: I_kr, I_Ka, Ibk

Parameters:

scaleFactor the scale factor that multiply the currents.

Definition at line 124 of file CorriasBuistSMCModified.cpp.

References mScaleFactorCarbonMonoxide.

void CorriasBuistSMCModified::SetFakeIccStimulusPresent ( bool present )

Set whether we want the fake ICC stimulus or not. It changes the member variable mFakeIccStimulusPresent (which is true by default).

Parameters:

present - true if we want the fake ICC stimulus, false otherwise

Definition at line 129 of file CorriasBuistSMCModified.cpp.

References mFakeIccStimulusPresent.

void CorriasBuistSMCModified::VerifyStateVariables ( ) [virtual]

Now empty

Reimplemented from AbstractParameterisedSystem< std::vector< double > >.

Definition at line 121 of file CorriasBuistSMCModified.cpp.

Friends And Related Function Documentation

friend class boost::serialization::access [friend]

Needed for serialization.

Reimplemented from AbstractCardiacCell.

Definition at line 60 of file CorriasBuistSMCModified.hpp.

Member Data Documentation

double CorriasBuistSMCModified::ACh [private]

acetylcholine conc (mM)

Definition at line 93 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::Asurf [private]

surface area (mm^2)

Definition at line 84 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::Asurf_in_cm_square [private]

Surface area in cm^2

Definition at line 83 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified().

double CorriasBuistSMCModified::Ca_o [private]

mM

Definition at line 124 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::CaiRest [private]

baseline Ca conc (mM)

Definition at line 94 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), and EvaluateYDerivatives().

double CorriasBuistSMCModified::Cm [private]

membrane capacitance, pF

Definition at line 81 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified().

double CorriasBuistSMCModified::EK [private]

Nernst potential for K (mV)

Definition at line 120 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::ENa [private]

Nernst potential for Na (mV)

Definition at line 121 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::EnsCC [private]

Nernst potential for nsCC (mV)

Definition at line 122 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::F [private]

nC/nmol

Definition at line 131 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::FoRT [private]

1/mV

Definition at line 132 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified().

double CorriasBuistSMCModified::gBK_max [private]

max conductance of IBK)

Definition at line 99 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified().

double CorriasBuistSMCModified::gCaL_max [private]

max conductance of ICaL

Definition at line 98 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::gcouple [private]

coupling conductance bewteen fake ICC and SMC

Definition at line 105 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), and EvaluateYDerivatives().

double CorriasBuistSMCModified::gKA_max [private]

max conductance of IKA

Definition at line 101 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::gKb_max [private]

max conductance of IKb

Definition at line 100 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::gKr_max [private]

max conductance of IKr

Definition at line 102 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::gLVA_max [private]

max conductance of ILVA

Definition at line 97 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::gNa_max [private]

max conductance of INa

Definition at line 103 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::gnsCC_max [private]

max conductance of InsCC

Definition at line 104 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::hCa [private]

conc for half inactivation of fCa

Definition at line 87 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), and EvaluateYDerivatives().

double CorriasBuistSMCModified::JCaExt_max [private]

max flux of CaSR (mM/ms)

Definition at line 106 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), and GetIIonic().

double CorriasBuistSMCModified::K_o [private]

mM

Definition at line 125 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified().

double CorriasBuistSMCModified::Ki [private]

intra K conc (mM)

Definition at line 91 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified().

bool CorriasBuistSMCModified::mFakeIccStimulusPresent [private]

True if the fake built-in ICC stimulus is present

Definition at line 79 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), GetFakeIccStimulusPresent(), and SetFakeIccStimulusPresent().

double CorriasBuistSMCModified::mScaleFactorCarbonMonoxide [private]

Scale factor for CO-affected currents Note that this the number that multiply the currents, hence it is not [CO], but a function of [CO] (for example, 2.8*[CO] - 0.1)

Definition at line 74 of file CorriasBuistSMCModified.hpp.

Referenced by CorriasBuistSMCModified(), EvaluateYDerivatives(), GetCarbonMonoxideScaleFactor(), GetIIonic(), and SetCarbonMonoxideScaleFactor().