DeltaNotchSrnModel.cpp

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*/
 
#include "DeltaNotchSrnModel.hpp"
 
DeltaNotchSrnModel::DeltaNotchSrnModel(boost::shared_ptr<AbstractCellCycleModelOdeSolver> pOdeSolver)
    : AbstractOdeSrnModel(2, pOdeSolver)
{
    if (mpOdeSolver == boost::shared_ptr<AbstractCellCycleModelOdeSolver>())
    {
#ifdef CHASTE_CVODE
        mpOdeSolver = CellCycleModelOdeSolver<DeltaNotchSrnModel, CvodeAdaptor>::Instance();
        mpOdeSolver->Initialise();
        mpOdeSolver->SetMaxSteps(10000);
#else
        mpOdeSolver = CellCycleModelOdeSolver<DeltaNotchSrnModel, RungeKutta4IvpOdeSolver>::Instance();
        mpOdeSolver->Initialise();
        SetDt(0.001);
#endif //CHASTE_CVODE
    }
    assert(mpOdeSolver->IsSetUp());
}
 
DeltaNotchSrnModel::DeltaNotchSrnModel(const DeltaNotchSrnModel& rModel)
    : AbstractOdeSrnModel(rModel)
{
    /*
     * Set each member variable of the new SRN model that inherits
     * its value from the parent.
     *
     * Note 1: some of the new SRN model's member variables
     * will already have been correctly initialized in its constructor.
     *
     * Note 2: one or more of the new SRN model's member variables
     * may be set/overwritten as soon as InitialiseDaughterCell() is called on
     * the new SRN model.
     *
     * Note 3: Only set the variables defined in this class. Variables defined
     * in parent classes will be defined there.
     */
 
    assert(rModel.GetOdeSystem());
    SetOdeSystem(new DeltaNotchOdeSystem(rModel.GetOdeSystem()->rGetStateVariables()));
}
 
AbstractSrnModel* DeltaNotchSrnModel::CreateSrnModel()
{
    return new DeltaNotchSrnModel(*this);
}
 
void DeltaNotchSrnModel::SimulateToCurrentTime()
{
    // Custom behaviour
    UpdateDeltaNotch();
 
    // Run the ODE simulation as needed
    AbstractOdeSrnModel::SimulateToCurrentTime();
}
 
void DeltaNotchSrnModel::Initialise()
{
    AbstractOdeSrnModel::Initialise(new DeltaNotchOdeSystem);
}
 
void DeltaNotchSrnModel::UpdateDeltaNotch()
{
    assert(mpOdeSystem != nullptr);
    assert(mpCell != nullptr);
 
    double mean_delta = mpCell->GetCellData()->GetItem("mean delta");
    mpOdeSystem->SetParameter("Mean Delta", mean_delta);
}
 
double DeltaNotchSrnModel::GetNotch()
{
    assert(mpOdeSystem != nullptr);
    double notch = mpOdeSystem->rGetStateVariables()[0];
    return notch;
}
 
double DeltaNotchSrnModel::GetDelta()
{
    assert(mpOdeSystem != nullptr);
    double delta = mpOdeSystem->rGetStateVariables()[1];
    return delta;
}
 
double DeltaNotchSrnModel::GetMeanNeighbouringDelta()
{
    assert(mpOdeSystem != nullptr);
    double mean_neighbouring_delta = mpOdeSystem->GetParameter("Mean Delta");
    return mean_neighbouring_delta;
}
 
void DeltaNotchSrnModel::OutputSrnModelParameters(out_stream& rParamsFile)
{
    // No new parameters to output, so just call method on direct parent class
    AbstractOdeSrnModel::OutputSrnModelParameters(rParamsFile);
}
 
// Declare identifier for the serializer
#include "SerializationExportWrapperForCpp.hpp"
CHASTE_CLASS_EXPORT(DeltaNotchSrnModel)
#include "CellCycleModelOdeSolverExportWrapper.hpp"
EXPORT_CELL_CYCLE_MODEL_ODE_SOLVER(DeltaNotchSrnModel)